Mark Hiatt
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View article: Leveraging Omics Data and Large Language Models to Identify Natural Substances Targeting Overexpressed Genes in Psoriasis
Leveraging Omics Data and Large Language Models to Identify Natural Substances Targeting Overexpressed Genes in Psoriasis Open
Background. Psoriasis is a chronic autoimmune disease marked by excessive skin cell growth and inflammation, driven by the overexpression of certain key genes. Advances in omics have revealed genes pivotal to psoriasis, while natural subst…
View article: Predicting the Risk of Progression from Barrett’s Esophagus to Esophageal Adenocarcinoma with a Mass-Spectrometry-Based Proteomic Panel
Predicting the Risk of Progression from Barrett’s Esophagus to Esophageal Adenocarcinoma with a Mass-Spectrometry-Based Proteomic Panel Open
Background Esophageal adenocarcinoma (EAC) is a highly aggressive cancer with poor prognosis, often arising from gastroesophageal reflux disease (GERD) and its precursor, Barrett’s esophagus (BE). Although only a small proportion of indivi…
View article: Repurposing Ivermectin and ATRA as Potential Therapeutics for Glioblastoma Multiforme
Repurposing Ivermectin and ATRA as Potential Therapeutics for Glioblastoma Multiforme Open
Background Glioblastoma multiforme (GBM) is the most aggressive and lethal form of primary brain tumor, characterized by rapid growth and resistance to conventional therapies. Despite advances in treatment, most patients succumb to the dis…
View article: Unveiling Chemotherapy’s Impact on Lung Cancer through Single-Cell Transcriptomics
Unveiling Chemotherapy’s Impact on Lung Cancer through Single-Cell Transcriptomics Open
Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and frequently affects non-smokers, especially women. It is characterized by a complex genetic profile and interactions with its microen…
View article: Comparing Single-Cell Transcriptomes of Blood and Cerebrospinal Fluid Leukocytes in Multiple Sclerosis
Comparing Single-Cell Transcriptomes of Blood and Cerebrospinal Fluid Leukocytes in Multiple Sclerosis Open
Background Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system, marked by inflammation, demyelination, and neurodegeneration. Diagnosis is complex due to overlapping symptoms with other neurological condi…
View article: Unlocking the Treatment of Facioscapulohumeral Muscular Dystrophy Type 2: The Bisphenol Connection
Unlocking the Treatment of Facioscapulohumeral Muscular Dystrophy Type 2: The Bisphenol Connection Open
Background Facioscapulohumeral muscular dystrophy type 2 (FSHD2) poses a significant challenge within the domain of neuromuscular disorders, marked by a progressive decline in muscle strength accompanied by tissue wasting. FSHD2 results fr…
View article: A Novel Perspective on Genes Driving Metastatic Pancreatic Cancer Revealed by Single-cell RNA Sequencing
A Novel Perspective on Genes Driving Metastatic Pancreatic Cancer Revealed by Single-cell RNA Sequencing Open
Background Pancreatic ductal adenocarcinoma (PDAC) is formidable in its advanced, metastatic stage. Aggressive spread of malignant cells from the pancreas to distant organs like the liver and lungs is often detected late, complicating trea…
View article: Insights from Single-Cell RNA-seq: Identifying the Actin Gene Family as Novel Drivers in Parkinson’s Disease
Insights from Single-Cell RNA-seq: Identifying the Actin Gene Family as Novel Drivers in Parkinson’s Disease Open
Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting millions of individuals worldwide. The complex etiology of PD involves a combination of genetic and environmental factors. The Actin family…
View article: CD83 Receptor Unveiled as a Therapeutic Target in Metastatic Breast Cancer through Single-Cell RNA-Seq
CD83 Receptor Unveiled as a Therapeutic Target in Metastatic Breast Cancer through Single-Cell RNA-Seq Open
Background Metastatic breast cancer is an advanced stage of the disease in which cancer cells have spread to organs beyond the breast, posing a significant clinical challenge, necessitating the development of novel therapeutic approaches. …
View article: Associations Among Optimal Lung Cancer Treatment, Clinical Outcomes, and Health Care Utilization in Patients Who Underwent Comprehensive Genomic Profiling
Associations Among Optimal Lung Cancer Treatment, Clinical Outcomes, and Health Care Utilization in Patients Who Underwent Comprehensive Genomic Profiling Open
Background: Although immune checkpoint inhibitor immunotherapies are contraindicated as first-line treatment of advanced non–small cell lung cancer (NSCLC) in patients with ALK rearrangement and EGFR mutation, many receive them. The purpos…
View article: Assessing Facioscapulohumeral Muscular Dystrophy through Comparative Analysis of Bulk and Single-Cell Transcriptomes
Assessing Facioscapulohumeral Muscular Dystrophy through Comparative Analysis of Bulk and Single-Cell Transcriptomes Open
Background Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disorder characterized by progressive weakening of the muscles. While the two types of FSHD (FSHD1 and FSHD2) have distinct genetic causes, they share similarities in th…
View article: Connecting Cancers to Chromosomal Locations Through Copy Number Variations
Connecting Cancers to Chromosomal Locations Through Copy Number Variations Open
Background In 1960, scientists Peter Nowell and David Hungerford made a groundbreaking discovery by identifying the first genetic abnormality linked to cancer using cytogenetics. This discovery marked the beginning of research into many ot…