Mark Higuchi
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View article: Episodic Exposure to Eucalyptus Smoke during Sperm Maturation Impairs Sperm Motility in Long Evans Rats
Episodic Exposure to Eucalyptus Smoke during Sperm Maturation Impairs Sperm Motility in Long Evans Rats Open
Epidemiologic studies have suggested a relationship with firefighting and exposure to wildland fire smoke with a heightened risk of male infertility. Herein, 12-week-old Long-Evans rats were exposed to smoldering eucalyptus smoke with conc…
View article: Benchmark Dose Modeling Approaches for Volatile Organic Chemicals Using a Novel Air-Liquid Interface <i>In Vitro</i> Exposure System
Benchmark Dose Modeling Approaches for Volatile Organic Chemicals Using a Novel Air-Liquid Interface <i>In Vitro</i> Exposure System Open
Inhalation is the most relevant route of volatile organic chemical (VOC) exposure; however, due to unique challenges posed by their chemical properties and poor solubility in aqueous solutions, in vitro chemical safety testing is predomina…
View article: Developing innovative treatment technologies for PFAS-containing wastes
Developing innovative treatment technologies for PFAS-containing wastes Open
The release of persistent per- and polyfluoroalkyl substances (PFAS) into the environment is a major concern for the United States Environmental Protection Agency (U.S. EPA). To complement its ongoing research efforts addressing PFAS conta…
View article: Mutagenicity and Pollutant Emission Factors of Solid-Fuel Cookstoves: Comparison with Other Combustion Sources
Mutagenicity and Pollutant Emission Factors of Solid-Fuel Cookstoves: Comparison with Other Combustion Sources Open
BACKGROUND: Emissions from solid fuels used for cooking cause ~4 million premature deaths per year. Advanced solid-fuel cookstoves are a potential solution, but they should be assessed by appropriate performance indicators, including biolo…
View article: New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing
New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing Open
Air pollution consists of highly variable and complex mixtures recognized as major contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled with limitations surrounding epidemiological and animal studies, ha…
View article: The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency
The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency Open
The U.S. Environmental Protection Agency (EPA) is faced with the challenge of efficiently and credibly evaluating chemical safety often with limited or no available toxicity data. The expanding number of chemicals found in commerce and the…
View article: Development of a large-scale computer-controlled ozone inhalation exposure system for rodents
Development of a large-scale computer-controlled ozone inhalation exposure system for rodents Open
Complete systems for laboratory-based inhalation toxicology studies are typically not commercially available; therefore, inhalation toxicologists utilize custom-made exposure systems. Here we report on the design, construction, testing, op…
View article: A new cell culture exposure system for studying the toxicity of volatile chemicals at the air–liquid interface
A new cell culture exposure system for studying the toxicity of volatile chemicals at the air–liquid interface Open
A cell culture exposure system (CCES) was developed to expose cells established at an air-liquid interface (ALI) to volatile chemicals. We characterized the CCES by exposing indigo dye-impregnated filter inserts inside culture wells to 125…
View article: Evaluation of an Air Quality Health Index for Predicting the Mutagenicity of Simulated Atmospheres
Evaluation of an Air Quality Health Index for Predicting the Mutagenicity of Simulated Atmospheres Open
No study has evaluated the mutagenicity of atmospheres with a calculated air quality health index (AQHI). Thus, we generated in a UV-light-containing reaction chamber two simulated atmospheres (SAs) with similar AQHIs but different proport…
View article: Mutagenicity and Lung Toxicity of Smoldering vs. Flaming Emissions from Various Biomass Fuels: Implications for Health Effects from Wildland Fires
Mutagenicity and Lung Toxicity of Smoldering vs. Flaming Emissions from Various Biomass Fuels: Implications for Health Effects from Wildland Fires Open
PM from different fuels and combustion phases have appreciable differences in lung toxic and mutagenic potency, and on a mass basis, flaming samples are more active, whereas smoldering samples have greater effect when EFs are taken into ac…
View article: Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures
Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures Open
Modifications to a VITROCELL exposure system were required to mitigate cytotoxicity caused by the absence of temperature and humidity control.
View article: Genetic Targets of Acute Toluene Inhalation in<i>Drosophila melanogaster</i>
Genetic Targets of Acute Toluene Inhalation in<i>Drosophila melanogaster</i> Open
Interpretation and use of data from high-throughput assays for chemical toxicity require links between effects at molecular targets and adverse outcomes in whole animals. The well-characterized genome of Drosophila melanogaster provides a …
View article: Mutagenicity and Pollutant Emission Factors of Solid-Fuel Cookstoves: Comparison with Other Combustion Sources
Mutagenicity and Pollutant Emission Factors of Solid-Fuel Cookstoves: Comparison with Other Combustion Sources Open
Mutlu E, Warren SH, Ebersviller SM, Kooter IM, Schmid JE, Dye JA, Linak WP, Gilmour MI, Jetter JJ, Higuchi M, DeMarini DM. 2016. Mutagenicity and pollutant emission factors of solid-fuel cookstoves: comparison with other combustion sources…