Márk Híveš
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View article: Genetic Variations in<i>TP53, RB1</i>, and<i>PTEN</i>in a Selected Sample of Slovak Patients With Metastatic Castration-resistant Prostate Cancer
Genetic Variations in<i>TP53, RB1</i>, and<i>PTEN</i>in a Selected Sample of Slovak Patients With Metastatic Castration-resistant Prostate Cancer Open
BACKGROUND/AIM: This report aimed to present identified variants with pathogenic potential in three genes —TP53, PTEN, and RB1 — in a selected sample of patients with metastatic castration-resistant prostate cancer (mCRPC) with or without …
View article: Polymorphisms in the gene encoding CYP1A2 influence prostate cancer risk and progression
Polymorphisms in the gene encoding CYP1A2 influence prostate cancer risk and progression Open
The role of the cytochrome P450 1A2 (CYP1A2) rs2472299, rs2470890 and rs11072508 polymorphisms in prostate cancer risk, disease progression and tumour development remains unclear. The potential associations of these three CYP1A2 polymorphi…
View article: The driving power of the cell cycle: cyclin-dependent kinases, cyclins and their inhibitors
The driving power of the cell cycle: cyclin-dependent kinases, cyclins and their inhibitors Open
The cell cycle covers cell proliferation and growth and is strictly regulated by cyclin-dependent kinase, cyclins and their inhibitors. Cyclin-dependent kinases are serine/threonine kinases that are activated in certain phases of the cell …
View article: The ubiquitous expression of pyruvate carboxylase among human prostate tumors
The ubiquitous expression of pyruvate carboxylase among human prostate tumors Open
Pyruvate carboxylase (PC) is a mitochondrial enzyme catalyzing the ATP-dependent reaction of pyruvate prolongation with bicarbonate ion to oxaloacetate. The synthesis of oxaloacetate by PC, an intermediate of the Krebs cycle, is recently r…
View article: Association between estrogen receptor β polymorphisms and prostate cancer in a Slovak population
Association between estrogen receptor β polymorphisms and prostate cancer in a Slovak population Open
Sex steroid hormones have important roles in the function of the prostate; however, they may also serve as factors in the initiation and progression of carcinogenesis. Estrogens, acting through estrogen receptors, may significantly affect …
View article: Association of<i>MDM2 T309G</i>(rs2279744) Polymorphism and Expression Changes With Risk of Prostate Cancer in the Slovak Population
Association of<i>MDM2 T309G</i>(rs2279744) Polymorphism and Expression Changes With Risk of Prostate Cancer in the Slovak Population Open
There is a potentially protective effect of the MDM2 GG genotype on the risk of prostate cancer in the Slovak male population.
View article: Differential profiling of prostate tumors versus benign prostatic tissues by using a 2DE-MALDI-TOF-based proteomic approach
Differential profiling of prostate tumors versus benign prostatic tissues by using a 2DE-MALDI-TOF-based proteomic approach Open
Oncoproteomic technologies offer a complementary approach to the understanding of cancer proteins' function and the translation of molecular knowledge into clinical practice. Our aim was to compare the proteomic profiles of prostate tumors…
View article: Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer
Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer Open
The pathogenic variants identified in this study are located in evolutionarily conserved regions of proteins and are highly likely to affect DNA repair efficiency.