Mark Hofmeyer
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View article: Evaluation of Women with Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study
Evaluation of Women with Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study Open
Background Rare variant genetics have been associated with peripartum cardiomyopathy (PPCM) but the role of genetics remains unsettled. Objective The study sought to compare dilated cardiomyopathy (DCM) genetic risk in first-degree relativ…
View article: Implementing Precision Medicine for Dilated Cardiomyopathy: Insights from The DCM Consortium
Implementing Precision Medicine for Dilated Cardiomyopathy: Insights from The DCM Consortium Open
Background Clinical genetic evaluation of dilated cardiomyopathy (DCM) is implemented variably or not at all. Identifying needs and barriers to genetic evaluations will enable strategies to enhance precision medicine care. Methods An onlin…
View article: Giant Cell Myocarditis vs Cardiac Sarcoidosis
Giant Cell Myocarditis vs Cardiac Sarcoidosis Open
Giant cell myocarditis (GCM) and cardiac sarcoidosis share clinical and histologic features, but whether they represent separate processes or lie on an inflammatory cardiomyopathy spectrum is unclear. We present a case of cardiogenic shock…
View article: Antecedent flu-like illness and onset of idiopathic dilated cardiomyopathy: The DCM Precision Medicine Study
Antecedent flu-like illness and onset of idiopathic dilated cardiomyopathy: The DCM Precision Medicine Study Open
Background Previous studies have speculated that a viral infection may act as a trigger in the development of idiopathic dilated cardiomyopathy (DCM) among individuals genetically at risk. This study aims to describe the frequency of DCM p…
View article: REALM-DCM: A Phase 3, Multinational, Randomized, Placebo-Controlled Trial of ARRY-371797 in Patients With Symptomatic <i>LMNA</i> -Related Dilated Cardiomyopathy
REALM-DCM: A Phase 3, Multinational, Randomized, Placebo-Controlled Trial of ARRY-371797 in Patients With Symptomatic <i>LMNA</i> -Related Dilated Cardiomyopathy Open
BACKGROUND: LMNA ( lamin A/C )-related dilated cardiomyopathy is a rare genetic cause of heart failure. In a phase 2 trial and long-term extension, the selective p38α MAPK (mitogen-activated protein kinase) inhibitor, ARRY-371797 (PF-07265…
View article: Edge-to-edge mitral repair for iatrogenic chordal rupture related to Impella 5.0
Edge-to-edge mitral repair for iatrogenic chordal rupture related to Impella 5.0 Open
Iatrogenic chordal rupture with severe mitral regurgitation is a rare but serious complication associated with the use of Impella device. We present a case of a 47-year-old man with ischemic cardiomyopathy who presented in cardiogenic shoc…
View article: Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study
Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study Open
BACKGROUND: Dilated cardiomyopathy (DCM) can lead to advanced disease, defined herein as necessitating a durable left ventricular assist device or a heart transplant (LVAD/HT). DCM is known to have a genetic basis, but the association of r…
View article: Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry
Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry Open
Importance Black patients with dilated cardiomyopathy (DCM) have increased familial risk and worse outcomes than White patients, but most DCM genetic data are from White patients. Objective To compare the rare variant genetic architecture …
View article: Effectiveness of the <i>Family Heart Talk</i> Communication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial
Effectiveness of the <i>Family Heart Talk</i> Communication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial Open
Background: Managing disease risk among first-degree relatives of probands diagnosed with a heritable disease is central to precision medicine. A critical component is often clinical screening, which is particularly important for condition…
View article: Knowledge of Genome Sequencing and Trust in Medical Researchers Among Patients of Different Racial and Ethnic Groups With Idiopathic Dilated Cardiomyopathy
Knowledge of Genome Sequencing and Trust in Medical Researchers Among Patients of Different Racial and Ethnic Groups With Idiopathic Dilated Cardiomyopathy Open
Importance Cardiovascular disease contributes outsized mortality in patients from underrepresented racial and ethnic groups. Understanding levels of trust in medical researchers and knowledge of genome sequencing may help identify barriers…
View article: Validating an Idiopathic Dilated Cardiomyopathy Diagnosis Using Cardiovascular Magnetic Resonance: The Dilated Cardiomyopathy Precision Medicine Study
Validating an Idiopathic Dilated Cardiomyopathy Diagnosis Using Cardiovascular Magnetic Resonance: The Dilated Cardiomyopathy Precision Medicine Study Open
Background: Coronary angiography to identify coronary artery disease has been foundational to distinguish the cause of dilated cardiomyopathy (DCM), including the assignment of idiopathic or ischemic cardiomyopathy. Late gadolinium enhance…
View article: Prevalence and Cumulative Risk of Familial Idiopathic Dilated Cardiomyopathy
Prevalence and Cumulative Risk of Familial Idiopathic Dilated Cardiomyopathy Open
ClinicalTrials.gov Identifier: NCT03037632.
View article: The impact of left ventricular size on outcomes after centrifugal-flow left ventricular assist device implantation
The impact of left ventricular size on outcomes after centrifugal-flow left ventricular assist device implantation Open
OBJECTIVES The influence of preoperative left ventricular size in outcomes following centrifugal-flow left ventricular assist device (LVAD) implantation has not been well characterized. METHODS A cohort of 313 patients who received a centr…
View article: Variant Interpretation for Dilated Cardiomyopathy
Variant Interpretation for Dilated Cardiomyopathy Open
Background: The hypothesis of the Dilated Cardiomyopathy Precision Medicine Study is that most dilated cardiomyopathy has a genetic basis. The study returns results to probands and, when indicated, to relatives. While both the American Col…
View article: Prospective evaluation of the cardiac safety of HER2-targeted therapies in patients with HER2-positive breast cancer and compromised heart function: the SAFE-HEaRt study
Prospective evaluation of the cardiac safety of HER2-targeted therapies in patients with HER2-positive breast cancer and compromised heart function: the SAFE-HEaRt study Open
This study provides safety data of HER2-targeted therapies in patients with breast cancer and reduced LVEF while receiving cardioprotective medications and close cardiac monitoring. Our results demonstrate the importance of collaboration b…
View article: Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy
Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy Open
Background— The cause of idiopathic dilated cardiomyopathy (DCM) is unknown by definition, but its familial subtype is considered to have a genetic component. We hypothesize that most idiopathic DCM, whether familial or nonfamilial, has a …