Mark I. McDermott
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View article: Mammalian START-like phosphatidylinositol transfer proteins – Physiological perspectives and roles in cancer biology
Mammalian START-like phosphatidylinositol transfer proteins – Physiological perspectives and roles in cancer biology Open
View article: A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation
A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation Open
Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P 3 defines a major eukaryotic pathway for translation of extracellular cues to intracellular signaling circuits. Mem…
View article: Author response: A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation
Author response: A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation Open
View article: A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated Protein Kinase C regulation
A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated Protein Kinase C regulation Open
Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P 3 defines a major eukaryotic pathway for translation of extracellular cues to intracellular signaling circuits. Mem…
View article: Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction Open
View article: Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction Open
SUMMARY Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns)…
View article: Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions
Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions Open
Phospholipids and sphingolipids play critical roles in signal transduction, intracellular membrane trafficking, and control of cell growth and survival. We discuss recent progress in the identification and characterization of a family of i…
View article: Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease
Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease Open
View article: Watermelon seeds and peels: fatty acid composition and cosmeceutical potential
Watermelon seeds and peels: fatty acid composition and cosmeceutical potential Open
Watermelon consumption results in generation of organic waste in the form of seeds and peels. We have evaluated the fatty acid profiles and antioxidant content of watermelon (Kinnaree cultivar) seed oil and peel wax. In addition, we assess…
View article: Mammalian phospholipase D: Function, and therapeutics
Mammalian phospholipase D: Function, and therapeutics Open
View article: The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes
The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes Open
View article: Sorting Nexin 27 (SNX27): A Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Trafficking
Sorting Nexin 27 (SNX27): A Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Trafficking Open
The underlying defect in cystic fibrosis is mutation of the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel expressed at the apical surface of lung epithelia. In addition to its export and main…
View article: Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle
Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle Open