Mark Izraelson
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View article: Molecule template estimation using Validator Barcodes in multiplex PCR for adaptive immune repertoire profiling
Molecule template estimation using Validator Barcodes in multiplex PCR for adaptive immune repertoire profiling Open
TCR- and BCR-sequencing (TCR/BCR-seq) are two important technologies in studying the immune repertoire of samples such as PBMCs or tumors. In their most common form, these assays combine multiplex PCR of the repertoire using primers target…
View article: Tracking antigen-specific T cell response to cancer immunotherapy
Tracking antigen-specific T cell response to cancer immunotherapy Open
In each human or model animal, T cell receptor (TCR) of each effector/memory T cell clone recognizes from one to several cognate peptide-MHC complexes (pMHC). Limited knowledge on TCR repertoire specificities restricts our capacity to rati…
View article: Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR
Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR Open
Allelic variability in the adaptive immune receptor loci, which harbor the gene segments that encode B cell and T cell receptors (BCR/TCR), is of critical importance for immune responses to pathogens and vaccines. Adaptive immune receptor …
View article: Robust detection of SARS-CoV-2 exposure in the population using T-cell repertoire profiling
Robust detection of SARS-CoV-2 exposure in the population using T-cell repertoire profiling Open
The COVID-19 pandemic offers a powerful opportunity to develop methods for monitoring the spread of infectious diseases based on their signatures in population immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) has become …
View article: Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis Open
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune therapy, but disease-associated T …
View article: Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR
Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR Open
Allelic variability in the adaptive immune receptor loci, which harbor the gene segments that encode B cell and T cell receptors (BCR/TCR), has been shown to be of critical importance for immune responses to pathogens and vaccines. In rece…
View article: A Rapid Method for Detection of Antigen-Specific B Cells
A Rapid Method for Detection of Antigen-Specific B Cells Open
The global SARS-CoV-2 pandemic has united the efforts of many scientists all over the world to develop wet-lab techniques and computational approaches aimed at the identification of antigen-specific T and B cells. The latter provide specif…
View article: Mice TCR datasets
Mice TCR datasets Open
TCR repertoires data for mice of various age groups
View article: Clonesets' metrics
Clonesets' metrics Open
Diversity and other clonesets' metrics
View article: Mice TCR datasets
Mice TCR datasets Open
TCR repertoires data for mice of various age groups
View article: Gene expression data
Gene expression data Open
Gene expression data
View article: Clonesets' metrics
Clonesets' metrics Open
Diversity and other clonesets' metrics
View article: Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs
Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs Open
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4 + T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptor…
View article: Measuring Intratumoral Heterogeneity of Immune Repertoires
Measuring Intratumoral Heterogeneity of Immune Repertoires Open
There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures-along with the associated heterogeneity of the tumor neoantigen landsc…
View article: The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging
The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging Open
Human aging is associated with a profound loss of thymus productivity, yet naïve T lymphocytes still maintain their numbers by division in the periphery for many years. The extent of such proliferation may depend on the cytokine environmen…
View article: Mice TCR datasets
Mice TCR datasets Open
TCR repertoires data for mice of various age groups
View article: T cell immunity does not age in a long-lived rodent species
T cell immunity does not age in a long-lived rodent species Open
Numerous studies have demonstrated that the percentage of naïve T cells and diversity of T cell receptor (TCR) repertoire decrease with age, with some findings likewise suggesting that increased repertoire diversity may be associated with …
View article: T cell immunity does not age in a long-lived rodent species
T cell immunity does not age in a long-lived rodent species Open
In this work we have analysed TCR alpha and beta chain repertoires in Spalax of different age groups. We demonstrated that unlike mice and humans TCR repertoire in Spalax does not shrink with age.
View article: Comparative analysis of murine T‐cell receptor repertoires
Comparative analysis of murine T‐cell receptor repertoires Open
Summary For understanding the rules and laws of adaptive immunity, high‐throughput profiling of T‐cell receptor ( TCR ) repertoires becomes a powerful tool. The structure of TCR repertoires is instructive even before the antigen specificit…
View article: Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice
Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice Open
The mechanisms leading to autoimmune and inflammatory diseases in the CNS have not been elucidated. The environmental triggers of the aberrant presence of CD4+ T cells in the CNS are not known. In this article, we report that abnormal β-ca…