Mark J A Wever
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View article: Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1
Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1 Open
PIF1 is a conserved helicase and G4 DNA binding and unwinding enzyme, with roles in genome stability. Human PIF1 (hPIF1) is poorly understood, but its functions can become critical for tumour cell survival during oncogene-driven replicatio…
View article: Therapeutic potential of compounds targeting SARS-CoV-2 helicase
Therapeutic potential of compounds targeting SARS-CoV-2 helicase Open
The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the SARS-CoV-2 helicase …