Mark Jesky
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View article: Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial
Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial Open
Background In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity program…
View article: The clinical value and cost effectiveness of a 6-month digital health intervention to improve physical activity and mental health-related quality of life in people with chronic kidney disease (Kidney BEAM): A multi-centre, randomised controlled trial
The clinical value and cost effectiveness of a 6-month digital health intervention to improve physical activity and mental health-related quality of life in people with chronic kidney disease (Kidney BEAM): A multi-centre, randomised controlled trial Open
There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health interve…
View article: The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease
The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease Open
This trial assessed the feasibility and acceptability of Kidney BEAM, a physical activity and emotional well-being self-management digital health intervention (DHI) for people with chronic kidney disease (CKD), which offers live and on-dem…
View article: Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK
Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK Open
Kidney Research UK.
View article: An Analysis of Vascular Access Thrombosis Events From the Proactive IV irOn Therapy in hemodiALysis Patients Trial
An Analysis of Vascular Access Thrombosis Events From the Proactive IV irOn Therapy in hemodiALysis Patients Trial Open
In PIVOTAL, VAT occurred in nearly 1 quarter of participants in a median of just >2 years. In this post hoc analysis, randomization to proactive i.v. iron treatment arms did not increase the risk of VAT.
View article: Collapsing Glomerulopathy Affecting Native and Transplant Kidneys in Individuals with COVID-19
Collapsing Glomerulopathy Affecting Native and Transplant Kidneys in Individuals with COVID-19 Open
Since the emergency of novel coronavirus COVID-19 (SARS-CoV-2) in December 2019, infections have spread rapidly across the world. The reported incidence of acute kidney injury (AKI) in the context of COVID-19 is variable, and its mechanism…
View article: Imbalanced turnover of collagen type III is associated with disease progression and mortality in high-risk chronic kidney disease patients
Imbalanced turnover of collagen type III is associated with disease progression and mortality in high-risk chronic kidney disease patients Open
Background Tubulointerstitial fibrosis is a major pathological feature in chronic kidney disease (CKD) and collagen type III (COL3) is a major component of the renal fibrotic scar. We hypothesized that a dysregulated turnover of COL3 is an…
View article: A novel biomarker of laminin turnover is associated with disease progression and mortality in chronic kidney disease
A novel biomarker of laminin turnover is associated with disease progression and mortality in chronic kidney disease Open
LG1M, a marker of basement membrane remodeling, is increased in serum and urine of patients with CKD and levels are associated with one-year disease progression, development of ESRD, and mortality.
View article: Studies of novel risk factors associated with chronic kidney disease in ethically diverse, high risk populations
Studies of novel risk factors associated with chronic kidney disease in ethically diverse, high risk populations Open
Chronic Kidney Disease (CKD) is common and often has a major impact on the health of those affected. In this thesis I have focused on areas of uncertainty that may have major implications for patient care.
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\nFirstly, I assessed the dete…
View article: Association between urinary free light chains and progression to end stage renal disease in chronic kidney disease
Association between urinary free light chains and progression to end stage renal disease in chronic kidney disease Open
Urinary FLCs have an association with progression to ESRD in patients with CKD which appears to be explained to a degree by their correlation with eGFR and ACR. Levels above the 75th centile do have an independent association with ESRD, bu…
View article: Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease
Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease Open
Patients with chronic kidney disease (CKD) have an increased risk of infection and poorer responses to vaccination. This suggests that CKD patients have an impaired responsiveness to all antigens, even those first encountered before CKD on…
View article: Early eculizumab use in atypical haemolytic uraemic syndrome in a Jehovah’s Witness refusing blood products
Early eculizumab use in atypical haemolytic uraemic syndrome in a Jehovah’s Witness refusing blood products Open
Thrombotic microangiopathy (TMA) is characterized by microscopic angiopathic haemolytic anaemia, thrombocytopenia and organ injury. Supportive therapies include the use of blood products. Recently the terminal complement inhibitor eculizum…
View article: SP274URINARY ENDOTROPHIN (PRO-C6), A DYNAMIC PRODUCT OF TYPE VI COLLAGEN FORMATION, PREDICTS DISEASE PROGRESSION AND MORTALITY IN PATIENTS WITH CHRONIC KIDNEY DISEASE
SP274URINARY ENDOTROPHIN (PRO-C6), A DYNAMIC PRODUCT OF TYPE VI COLLAGEN FORMATION, PREDICTS DISEASE PROGRESSION AND MORTALITY IN PATIENTS WITH CHRONIC KIDNEY DISEASE Open
expression of cytokine which had increased in microarray analysis by mRNA level (real-time PCR) and by protein level (ELISA) in time course.RESULTS: We confirmed both iron and TNF-alpha stimulation enhanced calcification by Alizarin Staini…
View article: SO015A NOVEL BIOMARKER OF LAMININ TURNOVER IS ASSOCIATED WITH MORTALITY AND DISEASE PROGRESSION IN CHRONIC KIDNEY DISEASE
SO015A NOVEL BIOMARKER OF LAMININ TURNOVER IS ASSOCIATED WITH MORTALITY AND DISEASE PROGRESSION IN CHRONIC KIDNEY DISEASE Open
INTRODUCTION AND AIMS: Patients with chronic kidney disease (CKD) have increased risk of progressing to end-stage renal disease (ESRD) and a high mortality rate. One of the major underlying causes of progression of renal failure is renal f…
View article: Serum endotrophin, a type VI collagen cleavage product, is associated with increased mortality in chronic kidney disease
Serum endotrophin, a type VI collagen cleavage product, is associated with increased mortality in chronic kidney disease Open
Serum ETP level is independently associated with mortality in CKD. This study provides the basis for further exploratory work to establish whether collagen type VI formation is mechanistically involved in the increased mortality risk assoc…
View article: Health-Related Quality of Life Impacts Mortality but Not Progression to End-Stage Renal Disease in Pre-Dialysis Chronic Kidney Disease: A Prospective Observational Study
Health-Related Quality of Life Impacts Mortality but Not Progression to End-Stage Renal Disease in Pre-Dialysis Chronic Kidney Disease: A Prospective Observational Study Open
Impaired HRQL is common in the pre-dialysis CKD population. Reduced HRQL, as demonstrated by problems with self-care or a lower EQ-5Dindex score, is associated with a higher risk for death but not ESRD. Multiple factors influence these asp…