Mark L. Everard
YOU?
Author Swipe
View article: Time to re-set our thinking about airways disease: lessons from history, the resurgence of chronic bronchitis / PBB and modern concepts in microbiology
Time to re-set our thinking about airways disease: lessons from history, the resurgence of chronic bronchitis / PBB and modern concepts in microbiology Open
In contrast to significant declines in deaths due to lung cancer and cardiac disease in Westernised countries, the mortality due to ‘chronic obstructive pulmonary disease’ (COPD) has minimally changed in recent decades while ‘the incidence…
View article: Chronic Bacterial Airways disease: the Pernicious Global Health Challenge Hidden in Plain Sight
Chronic Bacterial Airways disease: the Pernicious Global Health Challenge Hidden in Plain Sight Open
This manuscript is aimed at encouraging those interested in biofilms and their effects on microbial communities to view the study of chronic airways disease as one of the most challenging and potentially rewarding areas to focus on. To do …
View article: We should not underestimate the role of biofilms in persistent (chronic) bronchitis
We should not underestimate the role of biofilms in persistent (chronic) bronchitis Open
The study by Robyn L Marsh and colleagues1Marsh RL Binks MJ Smith-Vaughan HC et al.Prevalence and subtyping of biofilms present in bronchoalveolar lavage from children with protracted bacterial bronchitis or non-cystic fibrosis bronchiecta…
View article: Challenging the paradigm
Challenging the paradigm Open
While advocating for addressing "treatable traits" is admirable in that it reminds clinicians to consider the patient and not the disease, the use of this idea to promote dangerous changes in practice should be challenged. https://bit.ly/3…
View article: Controlled inhalation improves central and peripheral deposition in cystic fibrosis patients with moderate lung disease
Controlled inhalation improves central and peripheral deposition in cystic fibrosis patients with moderate lung disease Open
Aim With progressive impairment of lung function, deposition of inhaled drug in the lungs becomes progressively more central, limiting its effectiveness. This pilot study explored the possibility that long slow inhalations might improve de…
View article: Precision Medicine and Childhood Asthma: A Guide for the Unwary
Precision Medicine and Childhood Asthma: A Guide for the Unwary Open
Many thousands of articles relating to asthma appear in medical and scientific journals each year, yet there is still no consensus as to how the condition should be defined. Some argue that the condition does not exist as an entity and tha…
View article: Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis
Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis Open
Introduction: The airway microbiota has been linked to specific paediatric respiratory diseases, but studies are often small. It remains unclear whether particular bacteria are associated with a given disease, or if a more general, non-spe…
View article: Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That
Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That Open
The diagnosis and management of infants and children with a significant viral lower respiratory tract illness remains the subject of much debate and little progress. Over the decades various terms for such illnesses have been in and fallen…
View article: Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State
Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State Open
The defining feature of asthma is loss of normal post-natal homeostatic control of airways smooth muscle (ASM). This is the key feature that distinguishes asthma from all other forms of respiratory disease. Failure to focus on impaired ASM…
View article: Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis
Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis Open
BACKGROUND: Inhaled corticosteroids (ICS) are the primary treatment for persistent asthma. Currently available ICS have differing particle size due to both formulation and propellant, and it has been postulated that this may impact patient…
View article: Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells
Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells Open
Rationale: Respiratory syncytial virus (RSV) bronchiolitis causes significant infant mortality. Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of death remains unknown.Objectives: To determine wheth…
View article: Statistical Analysis Plan
Statistical Analysis Plan Open
SAP for the COVID-D Study
View article: Exhaled nitric oxide for the diagnosis of asthma in children and adults: a systematic review
Exhaled nitric oxide for the diagnosis of asthma in children and adults: a systematic review Open
The fraction of exhaled nitric oxide (FeNO) is a marker of eosinophilic inflammation, which is associated with some forms of asthma. Asthma is currently diagnosed using a pathway of tests including spirometery, airway reversability (respon…
View article: ERS statement on tracheomalacia and bronchomalacia in children
ERS statement on tracheomalacia and bronchomalacia in children Open
Tracheomalacia and tracheobronchomalacia may be primary abnormalities of the large airways or associated with a wide variety of congenital and acquired conditions. The evidence on diagnosis, classification and management is scant. There is…
View article: ‘Dry’ and ‘wet’ cough: how reliable is parental reporting?
‘Dry’ and ‘wet’ cough: how reliable is parental reporting? Open
Introduction Chronic cough in childhood is common and causes much parental anxiety. Eliciting a diagnosis can be difficult as it is a non-specific symptom indicating airways inflammation and this may be due to a variety of aetiologies. A k…
View article: Assessing polymicrobial interactions in a 3D primary airway epithelial cell model
Assessing polymicrobial interactions in a 3D primary airway epithelial cell model Open
Introduction: Mixed viral-bacterial aetiology is common in lower respiratory tract infections of children. However the pathogenic mechanisms involved are poorly understood. Using primary airway epithelial cells (AEC) derived from children …
View article: Key paediatric messages from the 2017 European Respiratory Society International Congress
Key paediatric messages from the 2017 European Respiratory Society International Congress Open
In this article, the group chairs of the Paediatric Assembly of the European Respiratory Society (ERS) highlight some of the most interesting findings presented at the 2017 ERS International Congress, which was held in Milan, Italy.
View article: The impact of persistent bacterial bronchitis on the pulmonary microbiome of children
The impact of persistent bacterial bronchitis on the pulmonary microbiome of children Open
The bacteria present in the lungs of patients with PBB were less diverse in terms of richness and evenness. The results validate the clinical diagnosis, and suggest that more attention to bacterial communities in children with chronic coug…
View article: Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a–mediated T reg expansion
Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a–mediated T reg expansion Open
Respiratory syncytial virus–bronchiolitis is a major independent risk factor for subsequent asthma, but the causal mechanisms remain obscure. We identified that transient plasmacytoid dendritic cell (pDC) depletion during primary Pneumovir…
View article: Current options in aerosolised drug therapy for children receiving respiratory support
Current options in aerosolised drug therapy for children receiving respiratory support Open
Summary Inhalation of aerosolised medications are the mainstay of treatment for a number of chronic lung diseases and have several advantages over systemically‐administered medications. These include more rapid onset of action for drugs su…
View article: The impact of persistent bacterial bronchitis on the pulmonary microbiome of children
The impact of persistent bacterial bronchitis on the pulmonary microbiome of children Open
Persistent bacterial bronchitis is a leading cause of chronic wet cough in young children. This study aimed to characterise the respiratory bacterial microbiota of healthy children and to assess the impact of the changes associated with th…
View article: ERS statement on protracted bacterial bronchitis in children
ERS statement on protracted bacterial bronchitis in children Open
This European Respiratory Society statement provides a comprehensive overview on protracted bacterial bronchitis (PBB) in children. A task force of experts, consisting of clinicians from Europe and Australia who manage children with PBB de…
View article: Infective respiratory syncytial virus is present in human cord blood samples and most prevalent during winter months
Infective respiratory syncytial virus is present in human cord blood samples and most prevalent during winter months Open
Demonstrating active RSV in CBMs suggests in utero transmission of infective virus to the fetus without causing overt disease. This is likely to have an important impact on immune development as well as future virus-host interactions, ther…
View article: The Influence of the Microbiome on Early-Life Severe Viral Lower Respiratory Infections and Asthma—Food for Thought?
The Influence of the Microbiome on Early-Life Severe Viral Lower Respiratory Infections and Asthma—Food for Thought? Open
Severe viral lower respiratory infections are a major cause of infant morbidity. In developing countries, respiratory syncytial virus (RSV)-bronchiolitis induces significant mortality, whereas in developed nations the disease represents a …
View article: Persistent and Recurrent Bacterial Bronchitis—A Paradigm Shift in Our Understanding of Chronic Respiratory Disease
Persistent and Recurrent Bacterial Bronchitis—A Paradigm Shift in Our Understanding of Chronic Respiratory Disease Open
The recent recognition that the conducting airways are not "sterile" and that they have their own dynamic microbiome, together with the rapid advances in our understanding of microbial biofilms and their roles in the causation of respirato…
View article: Key paediatric messages from the 2016 European Respiratory Society International Congress
Key paediatric messages from the 2016 European Respiratory Society International Congress Open
In this article, the Group Chairs of the Paediatric Assembly of the European Respiratory Society (ERS) highlight some of the most interesting abstracts presented at the 2016 ERS International Congress, which was held in London.
View article: STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma
STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma Open
NCT02451709; pre-result.