Mark L. Guillotte
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View article: Lipid A Structural Divergence in <i>Rickettsia</i> Pathogens
Lipid A Structural Divergence in <i>Rickettsia</i> Pathogens Open
Spikes in rickettsioses occur as deforestation, urbanization, and homelessness increase human exposure to blood-feeding arthropods. Still, effective Rickettsia vaccines remain elusive.
View article: A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity
A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity Open
Background Fleas (Insecta: Siphonaptera) are small flightless parasites of birds and mammals; their blood-feeding can transmit many serious pathogens (i.e. the etiological agents of bubonic plague, endemic and murine typhus). The lack of f…
View article: Additional file 6 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity
Additional file 6 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity Open
Additional file 6: Table S3. Analysis of C. felis proteins that did not cluster with other Holometabola.
View article: Additional file 5 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity
Additional file 5 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity Open
Additional file 5: Table S2. Pan-genomes across sequenced Holometabola.
View article: Additional file 7 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity
Additional file 7 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity Open
Additional file 7: Table S4. Elements of the C. felis microbiome and associated Wolbachia phylogeny estimation.
View article: Additional file 8 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity
Additional file 8 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity Open
Additional file 8: Table S5. Coverage of corrected PacBio reads against all 16,622 polished assembly contigs.
View article: Additional file 2 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity
Additional file 2 of A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity Open
Additional file 2: Table S1. Functional predictions and enrichment analysis of C. felis proteins.
View article: Rickettsia Lipid A Biosynthesis Utilizes the Late Acyltransferase LpxJ for Secondary Fatty Acid Addition
Rickettsia Lipid A Biosynthesis Utilizes the Late Acyltransferase LpxJ for Secondary Fatty Acid Addition Open
Lipopolysaccharide (LPS) triggers an inflammatory response through the TLR4-MD2 receptor complex and inflammatory caspases, a process mediated by the lipid A moiety of LPS. Species of Rickettsia directly engage both extracellular and intra…
View article: The Cat Flea (Ctenocephalides felis) Immune Deficiency Signaling Pathway Regulates Rickettsia typhi Infection
The Cat Flea (Ctenocephalides felis) Immune Deficiency Signaling Pathway Regulates Rickettsia typhi Infection Open
Rickettsia species are obligate intracellular bacteria with both conserved and lineage-specific strategies for invading and surviving within eukaryotic cells. One variable component of Rickettsia biology involves arthropod vectors: for ins…
View article: Wholly<i>Rickettsia</i>! Reconstructed Metabolic Profile of the Quintessential Bacterial Parasite of Eukaryotic Cells
Wholly<i>Rickettsia</i>! Reconstructed Metabolic Profile of the Quintessential Bacterial Parasite of Eukaryotic Cells Open
Reductive genome evolution has purged many metabolic pathways from obligate intracellular Rickettsia ( Alphaproteobacteria ; Rickettsiaceae ). While some aspects of host-dependent rickettsial metabolism have been characterized, the array o…
View article: RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism
RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism Open
Rickettsiae are obligate intracellular pathogens that induce their uptake into nonphagocytic cells; however, the events instigating this process are incompletely understood. Importantly, diverse Rickettsia species are predicted to utilize …
View article: The<i>Rickettsia</i>type IV secretion system: unrealized complexity mired by gene family expansion
The<i>Rickettsia</i>type IV secretion system: unrealized complexity mired by gene family expansion Open
Many prokaryotes utilize type IV secretion systems (T4SSs) to translocate substrates (e.g. nucleoprotein, DNA, protein) across the cell envelope, and/or to elaborate surface structures (i.e. pili or adhesins). Among eight distinct T4SS cla…