Mark Lambie
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View article: Incidence and risk of nephrolithiasis with uricosuric therapies for the treatment of gout: a systematic review and meta-analysis of randomized controlled trials and cohort studies
Incidence and risk of nephrolithiasis with uricosuric therapies for the treatment of gout: a systematic review and meta-analysis of randomized controlled trials and cohort studies Open
Objectives To assess the incidence and risk of nephrolithiasis in people receiving uricosuric therapies for gout. Methods A search was conducted using MEDLINE, Embase, Cochrane Library, Web of Science and Clinical Trials.gov electronic dat…
View article: #998 The association between analogue compared to human insulin, prescribed dialysate glucose load, body mass index and mortality in people with kidney failure and type 2 diabetes on peritoneal dialysis
#998 The association between analogue compared to human insulin, prescribed dialysate glucose load, body mass index and mortality in people with kidney failure and type 2 diabetes on peritoneal dialysis Open
Background and Aims Type II diabetes is highly prevalent in people with kidney failure on peritoneal dialysis, with a proportion requiring insulin therapy. Compared to human insulin, analogue (genetically altered) insulin has been associat…
View article: Cardiovascular and Renal Outcomes Following Acute Kidney Injury in Pregnancy: A Systematic Review and Meta‐Analysis
Cardiovascular and Renal Outcomes Following Acute Kidney Injury in Pregnancy: A Systematic Review and Meta‐Analysis Open
Background Acute kidney injury (AKI) in pregnancy is associated with adverse maternal and foetal outcomes. However, there is limited evidence regarding cardiac and renal outcomes associated with AKI in pregnancy. Objective To quantify and …
View article: Interplay between patient and centre factors in home therapy uptake: A sequences-of-regressions analysis using linked UK Renal Registry to centre survey data
Interplay between patient and centre factors in home therapy uptake: A sequences-of-regressions analysis using linked UK Renal Registry to centre survey data Open
Rationale & Objective Disparities in home dialysis therapy (HT) use may stem from the interplay between dialysis centre services and patient characteristics. We analysed how these factors directly and indirectly affect HT uptake in England…
View article: Poor glycemic control and its predictors among people living with diabetes in low- and middle-income countries: a systematic review and meta-analysis
Poor glycemic control and its predictors among people living with diabetes in low- and middle-income countries: a systematic review and meta-analysis Open
The pooled prevalence of poor glycemic control was significantly high in LMICs. Drinking alcohol, poor adherence to dietary recommendations, poor adherence to anti-diabetic medication, diabetes complications, and co-morbid conditions were …
View article: The clinical implications and cost-effectiveness of the provision of medical in addition to surgical catheter insertion for peritoneal dialysis in people with kidney failure
The clinical implications and cost-effectiveness of the provision of medical in addition to surgical catheter insertion for peritoneal dialysis in people with kidney failure Open
Background High-quality and timely peritoneal access is essential for effective peritoneal dialysis (PD). Existing comparisons of medical compared to surgical catheter insertion have focused on the incidence of catheter events, but the cos…
View article: How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England
How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England Open
Objective The proportion of people having home dialysis for kidney disease varies considerably by treating centre, socioeconomic deprivation levels in the area and to some extent ethnicity. This study aimed to gain in-depth insights into c…
View article: Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report
Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report Open
Background Technique survival, also reported with negative connotations as technique failure or transfer from peritoneal dialysis to haemodialysis, has been identified by patients, caregivers and health professionals as a critically import…
View article: Prevalence and Outcomes of Chronic Kidney Disease-Associated Pruritus
Prevalence and Outcomes of Chronic Kidney Disease-Associated Pruritus Open
Key Points CKD-associated pruritus is highly prevalent among peritoneal dialysis patients. Pruritus is associated with reduced health-related quality of life, and the composite of mortality and transfer to hemodialysis for peritoneal dialy…
View article: Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis
Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis Open
Peritoneal dialysis adoption and technique survival is affected by limitations related to peritoneal membrane longevity and metabolic alterations. Indeed, almost all peritoneal dialysis fluids exploit glucose as an osmotic agent that rapid…
View article: P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review
P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review Open
Background/Aims Uric acid nephrolithiasis is a recognised side-effect of uricosuric therapies and a contraindication to their use. The objective of this systematic review was to assess the incidence and risk of nephrolithiasis in people wi…
View article: Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis
Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis Open
Background Chronic kidney disease (CKD) is associated with an increased risk of adverse pregnancy outcomes, but the risk at different stages of CKD (defined by estimated glomerular filtration rate, eGFR) compared with women without CKD has…
View article: Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England
Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England Open
Background: Disparities in home dialysis uptake across England suggest inequity and unexplained variation in access. We surveyed staff at all English kidney centres to identify patterns in service organisation/delivery and explore correlat…
View article: Realtime Remote Detection of Evolving Peritonitis in Peritoneal Dialysis
Realtime Remote Detection of Evolving Peritonitis in Peritoneal Dialysis Open
Despite impressive reductions in infection rates over the last 3 decades with the global average decreasing from 0.600 episodes/patient-year in 1992 to 0.303 in 2019, peritonitis remains the major complication of peritoneal dialysis (PD) a…
View article: Gastric Acid Suppression Therapy and Its Association with Peritoneal Dialysis–Associated Peritonitis in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)
Gastric Acid Suppression Therapy and Its Association with Peritoneal Dialysis–Associated Peritonitis in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) Open
Key Points In a large multinational cohort of PD patients, any GAS use was not associated with an increased risk of all-organism peritonitis. For peritonitis, risks were particularly high among certain classes of organisms particularly for…
View article: Standards of diabetes care and burden of hypoglycaemia in people with diabetes on peritoneal dialysis: Results from a real-world clinical audit
Standards of diabetes care and burden of hypoglycaemia in people with diabetes on peritoneal dialysis: Results from a real-world clinical audit Open
There is limited data on the standards of diabetes care in people on peritoneal dialysis (PD). Our aim was to assess the standards of diabetes care and the burden of hypoglycaemia in people with diabetes on PD. We performed a retrospective…
View article: An update on absolute and relative indications for dialysis treatment modalities
An update on absolute and relative indications for dialysis treatment modalities Open
Background Choosing a dialysis modality is an important decision for people to make as their kidney failure progresses. In doing so, their options should be informed by any absolute or relative indications that may favour one modality over…
View article: The Peritoneal Membrane and Its Role in Peritoneal Dialysis
The Peritoneal Membrane and Its Role in Peritoneal Dialysis Open
A healthy and functional peritoneal membrane is key to achieving sufficient ultrafiltration and restoring fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membr…
View article: Home dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Home dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Open
Home dialysis modalities (home hemodialysis [HD] and peritoneal dialysis [PD]) are associated with greater patient autonomy and treatment satisfaction compared with in-center modalities, yet the level of home-dialysis use worldwide is low.…
View article: ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: Classification, measurement, interpretation and rationale for intervention
ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: Classification, measurement, interpretation and rationale for intervention Open
Peritoneal dialysis (PD) uses the peritoneal membrane for dialysis. The peritoneal membrane is a thin layer of tissue that lines the abdomen. The lining is used as a filter to help remove extra fluid and poisonous waste from the blood. Eve…
View article: Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle
Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle Open
Introduction Use of home dialysis by centres in the UK varies considerably and is decreasing despite attempts to encourage greater use. Knowing what drives this unwarranted variation requires in-depth understanding of centre cultural and o…