Mark Larance
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View article: Genetic variance in the murine defensin locus modulates glucose homeostasis
Genetic variance in the murine defensin locus modulates glucose homeostasis Open
View article: The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression
The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression Open
Ageing is one of the most significant risk factors for heart disease; however, it is still not clear how the human heart changes with age. Taking advantage of a unique set of pre‐mortem, cryopreserved, non‐diseased human hearts, we perform…
View article: SEC61B regulates calcium flux and platelet hyperreactivity in diabetes
SEC61B regulates calcium flux and platelet hyperreactivity in diabetes Open
Platelet hyperreactivity increases the risk of cardiovascular thrombosis in diabetes and failure of antiplatelet drug therapies. Elevated basal and agonist-induced calcium flux is a fundamental cause of platelet hyperreactivity in diabetes…
View article: Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy
Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy Open
View article: Uncovering bacterial pseudaminylation with pan-specific antibody tools
Uncovering bacterial pseudaminylation with pan-specific antibody tools Open
Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins that are critical for the virulence of human pathogens. However, a dearth of effective tools for d…
View article: Submembrane liprin-α1 clusters spatially localize insulin granule fusion
Submembrane liprin-α1 clusters spatially localize insulin granule fusion Open
Insulin granule fusion in pancreatic β cells localizes to where they contact the ECM of the islet capillaries. The mechanism(s) underpinning localization are unclear. Using glucose or high K+ stimulation or the global uncaging of Ca2+, we …
View article: Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH
Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH Open
Obesity is a major risk factor for metabolic-associated steatotic liver disease (MASLD), which can progress to metabolic-associated steatohepatitis (MASH). There are no validated non-invasive tests to stratify persons with obesity with a g…
View article: Protein O-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals
Protein O-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals Open
Domain-specific O-fucosylation is an unusual type of glycosylation, where the fucose is directly attached to the serine or threonine residues in specific protein domains via an O-linkage. O-fucosylated proteins play critical roles in a wid…
View article: Endothelial cell activation enhances thromboinflammation in vaccine-induced immune thrombotic thrombocytopenia
Endothelial cell activation enhances thromboinflammation in vaccine-induced immune thrombotic thrombocytopenia Open
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but serious complication of the ChAdOx1 nCOV-19 vaccine. In Australia, the diagnosis of VITT required the detection of antibodies against platelet factor 4 (PF4) in plasma…
View article: Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism
Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism Open
View article: FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains
FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains Open
View article: Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes
Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes Open
View article: Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies
Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies Open
View article: Antimycobacterial cyclic peptide natural products bind and dysregulate stress response chaperones
Antimycobacterial cyclic peptide natural products bind and dysregulate stress response chaperones Open
The protein quality control system is a promising and largely untapped mycobacterial target for the discovery of novel antibiotics. The ClpC1:ClpP1P2 protease is an essential component of the system and is involved in both regulatory and s…
View article: Myocardial Posttranscriptional Landscape in Peripartum Cardiomyopathy
Myocardial Posttranscriptional Landscape in Peripartum Cardiomyopathy Open
BACKGROUND: Pregnancy imposes significant cardiovascular adaptations, including progressive increases in plasma volume and cardiac output. For most women, this physiological adaptation resolves at the end of pregnancy, but some women devel…
View article: Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage
Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage Open
View article: Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer
Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer Open
View article: <b>Optimised proteomic analysis of insulin granules from MIN6 cells identifies Scamp3, a novel regulator of insulin secretion and content.</b>
<b>Optimised proteomic analysis of insulin granules from MIN6 cells identifies Scamp3, a novel regulator of insulin secretion and content.</b> Open
AbstractPancreatic b-cells in the Islets of Langerhans are key to maintaining glucose homeostasis, by secreting the peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that ha…
View article: Optimized Proteomic Analysis of Insulin Granules From MIN6 Cells Identifies Scamp3, a Novel Regulator of Insulin Secretion and Content
Optimized Proteomic Analysis of Insulin Granules From MIN6 Cells Identifies Scamp3, a Novel Regulator of Insulin Secretion and Content Open
Pancreatic β-cells in the islets of Langerhans are key to maintaining glucose homeostasis by secreting the peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), which recently have been consi…
View article: Genetic variance in the murine defensin locus modulates glucose homeostasis
Genetic variance in the murine defensin locus modulates glucose homeostasis Open
Insulin resistance is a heritable risk factor for many chronic diseases; however, the genetic drivers remain elusive. In seeking these, we performed genetic mapping of insulin sensitivity in 670 chow-fed Diversity Outbred in Australia (DOz…
View article: Moderate-Intensity Constant and High-Intensity Interval Training Confer Differential Metabolic Benefits in Skeletal Muscle, White Adipose Tissue, and Liver of Candidates to Undergo Bariatric Surgery
Moderate-Intensity Constant and High-Intensity Interval Training Confer Differential Metabolic Benefits in Skeletal Muscle, White Adipose Tissue, and Liver of Candidates to Undergo Bariatric Surgery Open
Background/Objectives: Bariatric surgery candidates require presurgical physical training, therefore, we compared the metabolic effects of a constant moderate-intensity training program (MICT) vs. a high-intensity interval training (HIIT) …
View article: Exploiting Hydrophobic Amino Acid Scanning to Develop Cyclic Peptide Inhibitors of the SARS‐CoV‐2 Main Protease with Antiviral Activity
Exploiting Hydrophobic Amino Acid Scanning to Develop Cyclic Peptide Inhibitors of the SARS‐CoV‐2 Main Protease with Antiviral Activity Open
The development of novel antivirals is crucial not only for managing current COVID‐19 infections but for addressing potential future zoonotic outbreaks. SARS‐CoV‐2 main protease (M pro ) is vital for viral replication and viability and the…
View article: Dynamic changes in RNA m6A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation
Dynamic changes in RNA m6A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation Open
View article: Optimised proteomic analysis of insulin granules from MIN6 β-cells identifies Scamp3, a novel regulator of insulin secretion and content
Optimised proteomic analysis of insulin granules from MIN6 β-cells identifies Scamp3, a novel regulator of insulin secretion and content Open
Pancreatic β-cells in the islets of Langerhans are key to maintaining glucose homeostasis, by secreting the peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that have recently been consi…
View article: Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice
Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice Open
This study identified a fatty liver lipid droplet proteome and one associated with glucose tolerance. Notably, glucose intolerance was linked with changes in the ratio of adipose triglyceride lipase to perilipin 5 that is indicative of dys…
View article: Ventricle-specific myocardial protein and metabolite characterisation in healthy humans, with differential regulation in end-stage cardiomyopathies
Ventricle-specific myocardial protein and metabolite characterisation in healthy humans, with differential regulation in end-stage cardiomyopathies Open
Background The left and right ventricles of the human heart are functionally and developmentally distinct such that genetic or acquired insults can cause dysfunction in one or both ventricles resulting in heart failure. The left ventricle …
View article: VPS41 deletion triggers progressive loss of insulin stores and downregulation of beta-cell identity
VPS41 deletion triggers progressive loss of insulin stores and downregulation of beta-cell identity Open
Summary Vacuolar protein sorting-associated protein 41 (VPS41) has been established as a requirement for normal insulin secretory function in pancreatic beta-cells. Genetic deletion of VPS41 in mouse pancreatic beta-cells results in diabet…
View article: The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure
The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure Open
View article: A multiomics dataset for the study of RNA modifications in human macrophage differentiation and polarisation
A multiomics dataset for the study of RNA modifications in human macrophage differentiation and polarisation Open
RNA modifications have emerged as central regulators of gene expression programs. Amongst RNA modifications are N6-methyladenosine (m 6 A) and RNA 5-hydroxymethylcytosine (5hmC). While m 6 A is established as a versatile regulator of RNA m…
View article: Correction: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
Correction: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus Open