Mark Lauer
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View article: Inter-pregnancy interval and uterine rupture during a trial of labour after one previous caesarean delivery and no previous vaginal births: a retrospective population-based cohort study
Inter-pregnancy interval and uterine rupture during a trial of labour after one previous caesarean delivery and no previous vaginal births: a retrospective population-based cohort study Open
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View article: Nitric oxide alters hyaluronan deposition by airway smooth muscle cells
Nitric oxide alters hyaluronan deposition by airway smooth muscle cells Open
Asthma is a chronic inflammatory disease that is known to cause changes in the extracellular matrix, including changes in hyaluronan (HA) deposition. However, little is known about the factors that modulate its deposition or the potential …
View article: TNF-stimulated gene 6 promotes formation of hyaluronan–inter-α-inhibitor heavy chain complexes necessary for ozone-induced airway hyperresponsiveness
TNF-stimulated gene 6 promotes formation of hyaluronan–inter-α-inhibitor heavy chain complexes necessary for ozone-induced airway hyperresponsiveness Open
Exposure to pollutants, such as ozone, exacerbates airway inflammation and hyperresponsiveness (AHR). TNF-stimulated gene 6 (TSG-6) is required to transfer inter-α-inhibitor heavy chains (HC) to hyaluronan (HA), facilitating HA receptor bi…
View article: The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity
The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity Open
The microenvironment provides a functional substratum supporting tumour growth. Hyaluronan (HA) is a major component of this structure. While the role of HA in malignancy is well-defined, the mechanisms driving its biosynthesis in cancer a…
View article: Pathological Hyaluronan Matrices in Cystic Fibrosis Airways and Secretions
Pathological Hyaluronan Matrices in Cystic Fibrosis Airways and Secretions Open
Hyaluronan (HA) has been used in treatment of cystic fibrosis (CF) via a nebulizer and has demonstrated success in clinical outcomes. HA is an important glycosaminoglycan that is cross-linked by heavy chains (HCs) from inter-α-inhibitor du…
View article: Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage
Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage Open
Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arrested oligodendrocyte progenitor cell (OPC) maturation, and reduced myelination of the white matter. Hyaluronan (HA) inhibits OPC maturation and complexes w…
View article: Hyaluronan Rafts on Airway Epithelial Cells
Hyaluronan Rafts on Airway Epithelial Cells Open
Many cells, including murine airway epithelial cells, respond to a variety of inflammatory stimuli by synthesizing leukocyte-adhesive hyaluronan (HA) cables that remain attached to their cell surfaces. This study shows that air-liquid inte…
View article: Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation
Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation Open
Hyaluronan (HA) is a large (>1500 kDa) polysaccharide of the extracellular matrix that has been linked to severity and inflammation in asthma. During inflammation, HA becomes covalently modified with heavy chains (HC-HA) from inter-α-inhib…
View article: Heavy Chain Transfer by Tumor Necrosis Factor-stimulated Gene 6 to the Bikunin Proteoglycan
Heavy Chain Transfer by Tumor Necrosis Factor-stimulated Gene 6 to the Bikunin Proteoglycan Open
We present data that hyaluronan (HA) polysaccharides, about 14-86 monosaccharides in length, are capable of accepting only a single heavy chain (HC) from inter-α-inhibitor via transfer by tumor necrosis factor-stimulated gene 6 (TSG-6) and…
View article: The Rise and Fall of Hyaluronan in Respiratory Diseases
The Rise and Fall of Hyaluronan in Respiratory Diseases Open
In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following pulmonary injury, elevated levels of HA matrices accumulate in thes…