Mark Leaver
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View article: Optical characterization of molecular interaction strength in protein condensates
Optical characterization of molecular interaction strength in protein condensates Open
Biomolecular condensates have been identified as a ubiquitous means of intracellular organization, exhibiting very diverse material properties. However, techniques to characterize these material properties and their underlying molecular in…
View article: Optical characterization of molecular interaction strength in protein condensates
Optical characterization of molecular interaction strength in protein condensates Open
Biomolecular condensates have been identified as a ubiquitous means of intracellular organization, exhibiting very diverse material properties. However, techniques to characterize these material properties and their underlying molecular in…
View article: Axis convergence in C. elegans embryos
Axis convergence in C. elegans embryos Open
Embryos develop in a surrounding that guides key aspects of their development. For example, the anteroposterior (AP) body axis is always aligned with the geometric long axis of the surrounding eggshell in fruit flies and worms. The mechani…
View article: [Dataset and Code] Axis convergence in C. elegans embryos
[Dataset and Code] Axis convergence in C. elegans embryos Open
Embryos develop in a surrounding that guides key aspects of their development. For example, the anteroposterior (AP) body axis is always aligned with the geometric long axis of the surrounding eggshell in fruit flies and worms. The mechani…
View article: [Dataset and Code] Axis convergence in C. elegans embryos
[Dataset and Code] Axis convergence in C. elegans embryos Open
Embryos develop in a surrounding that guides key aspects of their development. For example, the anteroposterior (AP) body axis is always aligned with the geometric long axis of the surrounding eggshell in fruit flies and worms. The mechani…
View article: Axis convergence in<i>C. elegans</i>embryos
Axis convergence in<i>C. elegans</i>embryos Open
Embryos develop in a surrounding that guides key aspects of their development. For example, the anteroposterior (AP) body axis is always aligned with the geometric long axis of the surrounding eggshell in fruit flies and worms. The mechani…
View article: Adaptation to environmental temperature in divergent clades of the nematode<i>Pristionchus pacificus</i>
Adaptation to environmental temperature in divergent clades of the nematode<i>Pristionchus pacificus</i> Open
Because of ongoing climate change, populations of organisms are being subjected to stressful temperatures more often. This is especially problematic for ectothermic organisms, which are likely to be more sensitive to changes in temperature…
View article: Orchestrating nonmuscle myosin II filament assembly at the onset of cytokinesis
Orchestrating nonmuscle myosin II filament assembly at the onset of cytokinesis Open
We investigate the dynamics of myosin during the assembly of the cytokinetic ring in the first during the first cell division in Caenorhabditis elegans embryos. We show regulated assembly and disassembly of myosin filaments and conclude th…
View article: Local thermodynamics govern formation and dissolution of <i>Caenorhabditis</i> elegans P granule condensates
Local thermodynamics govern formation and dissolution of <i>Caenorhabditis</i> elegans P granule condensates Open
Significance Living cells rely on a continuous flux of energy to spatially organize biochemical processes. It remains unclear whether cells can achieve this spatial organization via thermodynamic principles. Here, we report the striking be…
View article: Local thermodynamics governs the formation and dissolution of protein condensates in living cells
Local thermodynamics governs the formation and dissolution of protein condensates in living cells Open
Membraneless compartments, also known as condensates, provide chemically distinct environments and thus spatially organize the cell. A well-studied example of condensates is P granules in the roundworm C. elegans which play an important ro…
View article: Parallel adaptation to higher temperatures in divergent clades of the nematode<i>Pristionchus pacificus</i>
Parallel adaptation to higher temperatures in divergent clades of the nematode<i>Pristionchus pacificus</i> Open
Studying the effect of temperature on fertility is particularly important in the light of ongoing climate change. We need to know if organisms can adapt to higher temperatures and, if so, what are the evolutionary mechanisms behind such ad…
View article: A locus in<i>Pristionchus pacificus</i>that is responsible for the ability to give rise to fertile offspring at higher temperatures
A locus in<i>Pristionchus pacificus</i>that is responsible for the ability to give rise to fertile offspring at higher temperatures Open
Temperature is a stress factor that varies temporally and spatially, and can affect the fitness of cold-blooded organisms, leading to a loss of reproductive output; however, little is understood about the genetics behind the long-term resp…
View article: Genomic Profiles of Diversification and Genotype–Phenotype Association in Island Nematode Lineages
Genomic Profiles of Diversification and Genotype–Phenotype Association in Island Nematode Lineages Open
Understanding how new species form requires investigation of evolutionary forces that cause phenotypic and genotypic changes among populations. However, the mechanisms underlying speciation vary and little is known about whether genomes di…