Mark Liberman
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View article: Decoding Dementia from Speech: Acoustic‐Lexical Integration for Detecting Alzheimer's Disease in Older Korean Adults
Decoding Dementia from Speech: Acoustic‐Lexical Integration for Detecting Alzheimer's Disease in Older Korean Adults Open
Background Early detection of mild cognitive impairment due to Alzheimer's disease (MCI d/t AD), as well as AD dementia (ADD), is critical for timely intervention. Speech analysis offers a non‐invasive way to detect subtle cognitive defici…
View article: Automatic classification of patients in the AD spectrum from those in the DLB spectrum using speech
Automatic classification of patients in the AD spectrum from those in the DLB spectrum using speech Open
Background Early clinical symptoms of both Alzheimer's disease (AD) and dementia with Lewy body (DLB) include memory problems and difficulties in judgement and planning. With similar clinical symptoms, it is challenging to screen patients …
View article: Relation between Depression Dimensions and Speech Acoustic and Emotion‐based Features
Relation between Depression Dimensions and Speech Acoustic and Emotion‐based Features Open
Background Depression is a common and highly heterogeneous disorder in older adults, often linked to faster cognitive decline. While standard questionnaires are subjective, speech analysis may offer a more objective method for characterizi…
View article: Relation between Depression Dimensions and Speech Acoustic and Emotion‐based Features
Relation between Depression Dimensions and Speech Acoustic and Emotion‐based Features Open
Background Depression is a common and highly heterogeneous disorder in older adults, often linked to faster cognitive decline. While standard questionnaires are subjective, speech analysis may offer a more objective method for characterizi…
View article: Age distribution of speech duration measures in healthy individuals with picture description tasks
Age distribution of speech duration measures in healthy individuals with picture description tasks Open
Background Picture description tasks have been used to gauge communication capabilities of neurodegenerative patients. Previous studies have demonstrated that speech duration measures can help distinguish between healthy and neurodegenerat…
View article: Social Context Matters for Turn‐Taking Dynamics: A Comparative Study of Autistic and Typically Developing Children
Social Context Matters for Turn‐Taking Dynamics: A Comparative Study of Autistic and Typically Developing Children Open
Engaging in fluent conversation is a surprisingly complex task that requires interlocutors to promptly respond to each other in a way that is appropriate to the social context. In this study, we disentangled different dimensions of turn‐ta…
View article: Social Context Matters for Turn-Taking Dynamics: A Comparative Study of Autistic and Typically Developing Children
Social Context Matters for Turn-Taking Dynamics: A Comparative Study of Autistic and Typically Developing Children Open
Engaging in fluent conversation is a surprisingly complex task that requires interactantsto promptly respond to each other in a way that is appropriate to the social context. Inthis study, we disentangled different dimensions of turn-takin…
View article: Automated speech and language markers of longitudinal changes in psychosis symptoms
Automated speech and language markers of longitudinal changes in psychosis symptoms Open
We sought to evaluate the ability of automated speech and language features to longitudinally track fluctuations in the major psychosis domains: Thought Disorder , Negative Symptoms , and Positive Symptoms . Sixty-six participants with psy…
View article: Evaluating Speech-to-Text Systems with PennSound
Evaluating Speech-to-Text Systems with PennSound Open
A random sample of nearly 10 hours of speech from PennSound, the world's largest online collection of poetry readings and discussions, was used as a benchmark to evaluate several commercial and open-source speech-to-text systems. PennSound…
View article: Digital speech markers of cognitive impairment in ALS‐FTD spectrum disorders
Digital speech markers of cognitive impairment in ALS‐FTD spectrum disorders Open
Background Comorbid cognitive impairment in amyotrophic lateral sclerosis (i.e., ALS‐FTD), is associated with adverse clinical outcomes and survival. It often exhibits clinical features of behavioral variant frontotemporal dementia (bvFTD)…
View article: Automated analysis of story recall tasks produced by AD and MCI patients
Automated analysis of story recall tasks produced by AD and MCI patients Open
Background Story recall tasks are often employed in clinical settings to measure verbal episodic memory in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Traditional analyses (e.g. total number of recalled w…
View article: An automated method for quantifying syntactic complexity of spontaneous speech in Primary Progressive Aphasia
An automated method for quantifying syntactic complexity of spontaneous speech in Primary Progressive Aphasia Open
Background Reduced syntactic complexity is the predominant linguistic impairment unique to the nonfluent agrammatic variant of PPA (naPPA). Reliable, objective and automatic methods for assessing syntactic complexity are currently lacking.…
View article: Evolution of Linguistic Markers of Agency, Centrality and Content During Metacognitive Therapy for Psychosis: A Pilot Exploratory Study
Evolution of Linguistic Markers of Agency, Centrality and Content During Metacognitive Therapy for Psychosis: A Pilot Exploratory Study Open
Aim Metacognitive Reflection and Insight Therapy (MERIT) is a form of person‐centred psychotherapy that promotes recovery‐oriented outcomes by targeting metacognitive capacity. Previous research has shown the feasibility and clinical benef…
View article: Social Context Matters for Turn-Taking Dynamics: A Comparative Study of Autistic and Typically Developing Children
Social Context Matters for Turn-Taking Dynamics: A Comparative Study of Autistic and Typically Developing Children Open
Engaging in fluent conversation is a surprisingly complex task that requires interactantsto promptly respond to each other in a way that is appropriate to the social context. Inthis study, we disentangled different dimensions of turn-takin…
View article: Social Context Matters for Turn-Taking Dynamics: A Comparative Study of Autistic and Typically Developing Children
Social Context Matters for Turn-Taking Dynamics: A Comparative Study of Autistic and Typically Developing Children Open
Engaging in fluent conversation is a surprisingly complex task that requires interactantsto promptly respond to each other in a way that is appropriate to the social context. Inthis study, we disentangled different dimensions of turn-takin…
View article: Automated, Objective Speech and Language Markers of Longitudinal Changes in Psychosis Symptoms
Automated, Objective Speech and Language Markers of Longitudinal Changes in Psychosis Symptoms Open
Background and Hypotheses We sought to evaluate the ability of automated speech and language features to track fluctuations in the major psychosis symptoms domains: Thought Disorder, Negative Symptoms , and Positive Symptoms . Study Design…
View article: Speech markers of depression dimensions across cognitive status
Speech markers of depression dimensions across cognitive status Open
Introduction Depression and its components significantly impact dementia prediction and severity, necessitating reliable objective measures for quantification. Methods We investigated associations between emotion‐based speech measures (val…
View article: Automatic classification of AD pathology in FTD phenotypes using natural speech
Automatic classification of AD pathology in FTD phenotypes using natural speech Open
INTRODUCTION Screening for Alzheimer's disease neuropathologic change (ADNC) in individuals with atypical presentations is challenging but essential for clinical management. We trained automatic speech‐based classifiers to distinguish fron…
View article: Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration
Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration Open
Using automatic processing pipelines, we identified early changes in the natural speech of FTD pathogenic variant carriers in the presymptomatic stage. These findings highlight the potential utility of natural speech as a digital clinical …
View article: Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders
Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders Open
Automatic vowel measures are easily derived from a brief spontaneous speech sample, are sensitive to mild-moderate stage of bulbar disease in ALS-FTSD, and may present better sensitivity to bulbar impairment compared to traditional assessm…
View article: Automated lexical analysis of story recall in healthy controls
Automated lexical analysis of story recall in healthy controls Open
Background Impaired episodic memory is one of the earliest and most prominent symptoms of Alzheimer’s disease (AD). Examining how patients produce words and phrases in story recall tasks is useful for tracking and understanding progression…
View article: Speech markers of depression dimensions across the spectrum of cognitive functions
Speech markers of depression dimensions across the spectrum of cognitive functions Open
Background Depression is a common among patients with cognitive impairment and encompass different dimensions, which may vary in their association with cognitive outcomes and biological substrates. Previous studies have shown a shift towar…
View article: Automatic classification of underlying AD vs. FTLD pathology in people with clinical Frontotemporal Dementia using digital speech markers
Automatic classification of underlying AD vs. FTLD pathology in people with clinical Frontotemporal Dementia using digital speech markers Open
Background Recent studies show promising results using speech features to automatically distinguish patients with amnestic Alzheimer’s disease (AD) from healthy controls (HC). However these studies exclude atypical presentations of AD, whi…
View article: Comparison of category and letter fluency tasks through automated analysis
Comparison of category and letter fluency tasks through automated analysis Open
Introduction Category and letter fluency tasks are commonly used neuropsychological tasks to evaluate lexical retrieval. Methods This study used validated automated methods, which allow for more expansive investigation, to analyze speech p…
View article: Characterizing and detecting delirium with clinical and computational measures of speech and language disturbance
Characterizing and detecting delirium with clinical and computational measures of speech and language disturbance Open
Background: Delirium is a critically underdiagnosed syndrome of altered mental status affecting more than 50% of older adults admitted to hospital. Few studies have incorporated speech and language disturbance in delirium detection. We sou…
View article: Application of advanced language technologies in analysis of category naming fluency task in healthy participants
Application of advanced language technologies in analysis of category naming fluency task in healthy participants Open
Background Category naming fluency tasks have been used frequently to measure patients’ working memory and executive functions. Previous studies show that differences in scores in this task could reflect features of neurodegenerative disea…
View article: Digital markers of motor speech impairments in natural speech of patients with ALS-FTD spectrum disorders
Digital markers of motor speech impairments in natural speech of patients with ALS-FTD spectrum disorders Open
Background and objectives Patients with ALS-FTD spectrum disorders (ALS-FTSD) have mixed motor and cognitive impairments and require valid and quantitative assessment tools to support diagnosis and tracking of bulbar motor disease. This st…