Chien‐Chin Chen
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View article: Promoter demethylation and protein O-GlcNAcylation-mediated enhancement of fatty acid synthase contributes to hepatic steatosis and inflammation in MASLD
Promoter demethylation and protein O-GlcNAcylation-mediated enhancement of fatty acid synthase contributes to hepatic steatosis and inflammation in MASLD Open
Dysregulated lipid metabolism in hepatocytes heightens the risk of metabolic dysfunction-associated steatotic liver disease (MASLD). Fatty acid synthase (FAS), one of the key enzymes regulating lipid production in the liver, is upregulated…
View article: Antitumor and cytotoxic activities of endophytic Enterobacter hormaechei derived secondary metabolites: In-vitro and In-silico study
Antitumor and cytotoxic activities of endophytic Enterobacter hormaechei derived secondary metabolites: In-vitro and In-silico study Open
Anticancer therapies resistance, as well as their existing side effects, has become a significant issue worldwide. The demands of new anticancer agents that prevent cancer from developing and growing or spreading are increasing day by day.…
View article: Association of genotypes at single-nucleotide polymorphisms in IL-28B, TGF-β1, TP53, MTHFR and GSTP1 gene and their combinations with ischemic stroke: A case-control study
Association of genotypes at single-nucleotide polymorphisms in IL-28B, TGF-β1, TP53, MTHFR and GSTP1 gene and their combinations with ischemic stroke: A case-control study Open
Our results indicated that genotypes at the analyzed SNPs were associated with ischemic stroke in the screened Pakistani population.
View article: Association of TNF-α polymorphisms rs1800629 (−308G>A) and rs361525 (−238G>A) with type 2 diabetes mellitus in the Punjabi population of Pakistan
Association of TNF-α polymorphisms rs1800629 (−308G>A) and rs361525 (−238G>A) with type 2 diabetes mellitus in the Punjabi population of Pakistan Open
Background The TNF‐α -promoter polymorphisms rs1800629 (−308G>A) and rs361525 (−238G>A) have been variably associated with type 2 diabetes mellitus (T2DM) risk in different populations. This study evaluated these two polymorphisms in…
View article: Decoding the functional plasticity of milk-derived exosomes: implications for nutrition, immunity, and therapy
Decoding the functional plasticity of milk-derived exosomes: implications for nutrition, immunity, and therapy Open
Through the targeted release of immunologically active cargo, milk-derived exosomes (MDEs) are becoming increasingly important channels for maternal-neonatal communication. This study summarizes available data, showing that the bioactivity…
View article: Senescence‑associated IL‑33 secretion undermines sorafenib efficacy in hepatocellular carcinoma via immune evasion
Senescence‑associated IL‑33 secretion undermines sorafenib efficacy in hepatocellular carcinoma via immune evasion Open
Hepatocellular carcinoma (HCC) is a highly lethal cancer with increasing incidence rates worldwide. The recommended treatments for advanced‑stage HCC are sorafenib and regorafenib; however, developing resistance to these medications signif…
View article: The emerging role of extracellular vesicles in viral transmission and immune evasion
The emerging role of extracellular vesicles in viral transmission and immune evasion Open
Extracellular vesicles (EVs) are membrane-bound structures that serve as major mediators of intercellular communication, playing a crucial role in various physiological and pathological processes. These membrane-bound vesicles are involved…
View article: The emerging role of tissue regulatory T cells in tissue repair and regeneration
The emerging role of tissue regulatory T cells in tissue repair and regeneration Open
Regulatory T cells (Tregs) are a unique subset of T cells vital for maintaining immune balance, preventing autoimmune diseases, and controlling immune responses. First identified in the early 1990s, Tregs are now well recognized for their …
View article: Pulmonary Mass as the First Clinical Manifestation of Histiocytic Sarcoma with Multi-Organ Involvement: A Case Report and Review of the Literature
Pulmonary Mass as the First Clinical Manifestation of Histiocytic Sarcoma with Multi-Organ Involvement: A Case Report and Review of the Literature Open
Histiocytic sarcoma is a malignant neoplasm with cells showing morphologic and immunohistochemical features of histiocytes. The lung and stomach are rare sites of involvement, and few have been reported in the existing literature. We repor…
View article: Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway
Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway Open
Biomarkers that predict disease progression may assist in the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. This study aimed to investigate the role of collagen type IV alpha 6 (COL4A6) in cel…
View article: Tumor-infiltrating lymphocytes are the key determinants of pathological features associated with pathogenic BRCA variants in high-grade serous ovarian carcinoma
Tumor-infiltrating lymphocytes are the key determinants of pathological features associated with pathogenic BRCA variants in high-grade serous ovarian carcinoma Open
Background High-grade serous ovarian carcinoma (HGSOC), an aggressive cancer associated with pathogenic BRCA variants, causes genomic instability and sensitivity to poly (ADP-ribose) polymerase inhibitors. Identifying pathogenic BRCA varia…
View article: Knowledge, attitudes, and practices regarding dengue and its vectors among medical professionals: a cross-sectional study
Knowledge, attitudes, and practices regarding dengue and its vectors among medical professionals: a cross-sectional study Open
Dengue fever remains a significant global public health issue, necessitating a collaborative One Health strategy for efficient management. This cross-sectional study evaluated the knowledge, attitudes, and practices (KAP) of 516 healthcare…
View article: Bacteriophage therapy: a possible alternative therapy against antibiotic-resistant strains of Klebsiella pneumoniae
Bacteriophage therapy: a possible alternative therapy against antibiotic-resistant strains of Klebsiella pneumoniae Open
Klebsiella pneumoniae is a notorious, Gram-negative pathogen and is a leading cause of healthcare settings and community-acquired infections. This is the commensal of human microbiota and can invade and cause infections in different body p…
View article: Green synthesis of silver nanoparticles and characterization using <i>Asparagus officinalis</i> : Elucidation of Anti-diabetic potentials through In-Silico, In-Vitro, and In-Vivo Analyses
Green synthesis of silver nanoparticles and characterization using <i>Asparagus officinalis</i> : Elucidation of Anti-diabetic potentials through In-Silico, In-Vitro, and In-Vivo Analyses Open
Diabetes mellitus (DM), a serious health risk, can result in several problems and fatalities. This study investigates greensynthesized silver nanoparticles from Asparagus officinalis (AO-AgNPs) for their anti-diabetic properties. AO-AgNPs …
View article: Impact of oral precancerous lesions on oral cancer development in patients with oral lichen planus: a retrospective cohort study of 318 oral lichen planus patients
Impact of oral precancerous lesions on oral cancer development in patients with oral lichen planus: a retrospective cohort study of 318 oral lichen planus patients Open
Background Oral lichen planus (OLP) has been implicated as a potential risk factor for oral cancer. This study aimed to investigate the long-term determinants of oral cancer development following a diagnosis of OLP. Materials and methods A…
View article: Synergistic drug combination screening using a nanodroplet processing platform to enhance neuroblastoma treatment in <scp>TH</scp>‐<scp>MYCN</scp> transgenic mice
Synergistic drug combination screening using a nanodroplet processing platform to enhance neuroblastoma treatment in <span>TH</span>‐<span>MYCN</span> transgenic mice Open
Neuroblastoma is a highly aggressive pediatric cancer with a poor prognosis, particularly in high‐risk (HR) cases characterized by MYCN amplification. The severe side effects associated with high‐dose chemotherapy further complicate treatm…
View article: Costs of biomarker testing in advanced non‐small cell lung cancer: a global study comparing next‐generation sequencing and single‐gene testing
Costs of biomarker testing in advanced non‐small cell lung cancer: a global study comparing next‐generation sequencing and single‐gene testing Open
Current European/US guidelines recommend that molecular testing in advanced non‐small cell lung cancer (aNSCLC) be performed using next‐generation sequencing (NGS). However, the global uptake of NGS is limited, largely owing to reimburseme…
View article: Epidemiology and Clinical Characteristics of Laboratory-Confirmed COVID-19 and Influenza Infections in Children: A 2015–2024 Study in Taiwan
Epidemiology and Clinical Characteristics of Laboratory-Confirmed COVID-19 and Influenza Infections in Children: A 2015–2024 Study in Taiwan Open
The COVID-19 pandemic and Taiwan’s strict prevention policies from May 2020 to April 2023 significantly altered the epidemiology of viral infections. This study analyzed pediatric COVID-19 and influenza cases at Wei Gong Memorial Hospital …
View article: Knowledge, attitude, and perception of Pakistani populations toward monkeypox: a cross-section study
Knowledge, attitude, and perception of Pakistani populations toward monkeypox: a cross-section study Open
Objective The reappearance of monkeypox in non-endemic countries has preceded critical public health concerns. The public’s adherence to preventative measures is influenced by their understanding of the infectious monkeypox virus (Mpox), a…
View article: Knowledge, attitudes, and practices toward leishmaniasis and one health: a cross-sectional study among medical and veterinary professionals
Knowledge, attitudes, and practices toward leishmaniasis and one health: a cross-sectional study among medical and veterinary professionals Open
Leishmaniasis is a significant zoonotic infection with global health implications, particularly in regions where human and animal health are closely interconnected. This cross-sectional study assessed the knowledge, attitudes, and practice…
View article: Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches
Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches Open
Rickettsia felis , responsible for flea-borne spotted fever, is a rising zoonotic pathogen posing an increasing global threat due to its expanding geographical distribution. The rise in antibiotic-resistant strains of this pathogen undersc…
View article: Traditional uses, botanical description, phytochemistry, and pharmacological activities of Phytolacca acinosa: a review
Traditional uses, botanical description, phytochemistry, and pharmacological activities of Phytolacca acinosa: a review Open
Background Phytolacca acinosa is an herbaceous herb belonging to the Phytolaccaceae family. The plant has a long history of usage in traditional medicine for treating a variety of ailments including infectious diseases, edema, inflammation…
View article: Impact of climate change on the tick-host-pathogen complex: distribution patterns, disease incidence, and host infestation
Impact of climate change on the tick-host-pathogen complex: distribution patterns, disease incidence, and host infestation Open
Ticks, being ectothermic, are highly sensitive to climate variables, such as temperature, humidity, and precipitation. Over the past century, fossil fuel use has altered the climate and significantly affected the tick-host-pathogen system.…
View article: Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation
Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation Open
The gut harbors trillions of microbes that play essential roles in metabolism and immunological functions. The virome, an important but understudied component of the gut microbiota, comprises bacteriophages commonly referred to as bacteria…
View article: In vitro Bioassay and In silico Pharmacokinetic Characteristics of Xanthium strumarium Plant Extract as Possible Acaricidal Agent
In vitro Bioassay and In silico Pharmacokinetic Characteristics of Xanthium strumarium Plant Extract as Possible Acaricidal Agent Open
Background: Effective management strategies against tick infestations are necessary because tickborne diseases represent serious hazards to the health of humans and animals worldwide. The aim of this study was to examine the larvicidal and…
View article: Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature
Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature Open
Most abscopal effects are reported as sporadic and unpredictable events following radiotherapy at symptomatic sites. Herein, we report a case in which a planned abscopal effect was induced following deliberate radiotherapy and concurrent s…
View article: Exploration of Klebsiella aerogenes derived secondary metabolites and their antibacterial activities against multidrug-resistant bacteria
Exploration of Klebsiella aerogenes derived secondary metabolites and their antibacterial activities against multidrug-resistant bacteria Open
As the effectiveness of current treatments against the development of antimicrobial resistance is declining, new strategies are required. A great source of novel secondary metabolites with therapeutics effects are the endophytic bacteria p…