Mark Lommel
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View article: The conserved membrane-proximal domain of Sbh1/ Sec61β guides signal peptides into the Sec61 channel
The conserved membrane-proximal domain of Sbh1/ Sec61β guides signal peptides into the Sec61 channel Open
Protein secretion begins with protein translocation through the universally conserved Sec61 channel in the endoplasmic reticulum (ER) membrane. The function of its β-subunit, called Sbh1 in yeast, remains poorly understood. Sbh1/Sec61β has…
View article: <scp>SPIRO</scp> – the automated Petri plate imaging platform designed by biologists, for biologists
<span>SPIRO</span> – the automated Petri plate imaging platform designed by biologists, for biologists Open
SUMMARY Phenotyping of model organisms grown on Petri plates is often carried out manually, despite the procedures being time‐consuming and laborious. The main reason for this is the limited availability of automated phenotyping facilities…
View article: Injury-induced MAPK activation triggers body axis formation in <i>Hydra</i> by default Wnt signaling
Injury-induced MAPK activation triggers body axis formation in <i>Hydra</i> by default Wnt signaling Open
Hydra ’s almost unlimited regenerative potential is based on Wnt signaling, but so far it is unknown how the injury stimulus is transmitted to discrete patterning fates in head and foot regenerates. We previously identified mitogen-activat…
View article: A Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C- and O-Mannosylated Peptides
A Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C- and O-Mannosylated Peptides Open
Mass spectrometry (MS) easily detects C-mannosylated peptides from purified proteins but not from complex biological samples. Enrichment of specific glycopeptides by lectin affinity prior to MS analysis has been widely applied to support g…
View article: SPIRO – the automated Petri plate imaging platform designed by biologists, for biologists
SPIRO – the automated Petri plate imaging platform designed by biologists, for biologists Open
Phenotyping of model organisms grown on Petri plates is often carried out manually, despite the procedures being time-consuming and laborious. The main reason for this is the limited availability of automated phenotyping facilities, wherea…
View article: Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction
Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction Open
Thrombospondins (TSPs) are multidomain glycoproteins with complex matricellular functions in tissue homeostasis and remodeling. We describe a novel role of TSP as a Wnt signaling target in the basal eumetazoan Hydra . Proteome analysis ide…
View article: Genetic knockdown and knockout approaches in Hydra
Genetic knockdown and knockout approaches in Hydra Open
Hydra is a member of the Cnidaria, an ancient phylum at the base of metazoan evolution and sister group to all bilaterian animals. The regeneration capacity of Hydra, mediated by its stem cell systems is unparalleled in the animal kingdom.…
View article: Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates
Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates Open
Protein O-mannosylation is a post-translational modification essential for correct development of mammals. In humans, deficient O-mannosylation results in severe congenital muscular dystrophies often associated with impaired brain and eye …