Mark M. Bissell
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View article: Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative
Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative Open
Importance: The National COVID Cohort Collaborative (N3C) is a centralized, harmonized, high-granularity electronic health record repository that is the largest, most representative COVID-19 cohort to date. This multicenter data set can su…
View article: Synergies between centralized and federated approaches to data quality: a report from the national COVID cohort collaborative
Synergies between centralized and federated approaches to data quality: a report from the national COVID cohort collaborative Open
OBJECTIVE: In response to COVID-19, the informatics community united to aggregate as much clinical data as possible to characterize this new disease and reduce its impact through collaborative analytics. The National COVID Cohort Collabora…
View article: Racial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US
Racial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US Open
Importance Understanding whether there are racial and ethnic and residential disparities in prenatal telehealth uptake is necessary for ensuring equitable access and guiding implementation of future hybrid (ie, both telehealth and in-perso…
View article: Tree-based classification model for Long-COVID infection prediction with age stratification using data from the National COVID Cohort Collaborative
Tree-based classification model for Long-COVID infection prediction with age stratification using data from the National COVID Cohort Collaborative Open
Objectives We propose and validate a domain knowledge-driven classification model for diagnosing post-acute sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID, using Electronic Health Records (EHRs) data. Materials and Metho…
View article: Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study
Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study Open
Background Patients with coronavirus disease 2019 (COVID-19) often experience persistent symptoms, known as postacute sequelae of COVID-19 or long COVID, after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Chronic…
View article: Characterizing the impact of SARS-CoV-2 reinfection on surgical outcomes
Characterizing the impact of SARS-CoV-2 reinfection on surgical outcomes Open
The COVID-19 pandemic has changed the delivery of surgical care.Early in the pandemic, an association between SARS-CoV-2 infection and adverse postoperative outcomes prompted the implementation of risk mitigation strategies, including rout…
View article: Outcomes of patients with active cancers and pre-existing cardiovascular diseases infected with SARS-CoV-2
Outcomes of patients with active cancers and pre-existing cardiovascular diseases infected with SARS-CoV-2 Open
View article: Nonelective coronary artery bypass graft outcomes are adversely impacted by Coronavirus disease 2019 infection, but not altered processes of care: A National COVID Cohort Collaborative and National Surgery Quality Improvement Program analysis
Nonelective coronary artery bypass graft outcomes are adversely impacted by Coronavirus disease 2019 infection, but not altered processes of care: A National COVID Cohort Collaborative and National Surgery Quality Improvement Program analysis Open
Traditional care processes were altered during the COVID-19 pandemic. Our data show that nonelective CABG in patients with active COVID-19 is associated with significantly increased rates of mortality and pneumonia. The equivalent mortalit…
View article: Who is pregnant? Defining real-world data-based pregnancy episodes in the National COVID Cohort Collaborative (N3C)
Who is pregnant? Defining real-world data-based pregnancy episodes in the National COVID Cohort Collaborative (N3C) Open
Objectives To define pregnancy episodes and estimate gestational age within electronic health record (EHR) data from the National COVID Cohort Collaborative (N3C). Materials and Methods We developed a comprehensive approach, named Hierarch…
View article: National Trends in Anticoagulation Therapy for COVID-19 Hospitalized Adults in the United States: Analyses of the National COVID Cohort Collaborative
National Trends in Anticoagulation Therapy for COVID-19 Hospitalized Adults in the United States: Analyses of the National COVID Cohort Collaborative Open
Background Anticoagulation (AC) utilization patterns and their predictors among hospitalized coronavirus disease 2019 (COVID-19) patients have not been well described. Methods Using the National COVID Cohort Collaborative, we conducted a r…
View article: COVID-19 outcomes in persons with hemophilia: results from a US-based national COVID-19 surveillance registry
COVID-19 outcomes in persons with hemophilia: results from a US-based national COVID-19 surveillance registry Open
View article: Hormone replacement therapy and COVID-19 outcomes in solid organ transplant recipients compared with the general population
Hormone replacement therapy and COVID-19 outcomes in solid organ transplant recipients compared with the general population Open
View article: Risk for stillbirth among pregnant individuals with SARS-CoV-2 infection varied by gestational age
Risk for stillbirth among pregnant individuals with SARS-CoV-2 infection varied by gestational age Open
View article: Risk of severe acute respiratory syndrome coronavirus 2 infection among women with polycystic ovary syndrome
Risk of severe acute respiratory syndrome coronavirus 2 infection among women with polycystic ovary syndrome Open
View article: Vaccination Against SARS-CoV-2 Decreases Risk of Adverse Events in Patients who Develop COVID-19 Following Cancer Surgery
Vaccination Against SARS-CoV-2 Decreases Risk of Adverse Events in Patients who Develop COVID-19 Following Cancer Surgery Open
View article: Harmonizing units and values of quantitative data elements in a very large nationally pooled electronic health record (EHR) dataset
Harmonizing units and values of quantitative data elements in a very large nationally pooled electronic health record (EHR) dataset Open
Objective The goals of this study were to harmonize data from electronic health records (EHRs) into common units, and impute units that were missing. Materials and Methods The National COVID Cohort Collaborative (N3C) table of laboratory m…
View article: Demonstrating an approach for evaluating synthetic geospatial and temporal epidemiologic data utility: results from analyzing >1.8 million SARS-CoV-2 tests in the United States National COVID Cohort Collaborative (N3C)
Demonstrating an approach for evaluating synthetic geospatial and temporal epidemiologic data utility: results from analyzing >1.8 million SARS-CoV-2 tests in the United States National COVID Cohort Collaborative (N3C) Open
Objective This study sought to evaluate whether synthetic data derived from a national coronavirus disease 2019 (COVID-19) dataset could be used for geospatial and temporal epidemic analyses. Materials and Methods Using an original dataset…
View article: Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19
Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19 Open
In this cohort study of US adults hospitalized with moderate COVID-19, early aspirin use was associated with lower odds of 28-day in-hospital mortality. A randomized clinical trial that includes diverse patients with moderate COVID-19 is w…
View article: Synergies between centralized and federated approaches to data quality: a report from the national COVID cohort collaborative
Synergies between centralized and federated approaches to data quality: a report from the national COVID cohort collaborative Open
Objective In response to COVID-19, the informatics community united to aggregate as much clinical data as possible to characterize this new disease and reduce its impact through collaborative analytics. The National COVID Cohort Collaborat…
View article: Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative
Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative Open
This cohort study found that COVID-19 mortality decreased over time during 2020 and that patient demographic characteristics and comorbidities were associated with higher clinical severity. The machine learning models accurately predicted …
View article: The National COVID Cohort Collaborative: Clinical Characterization and Early Severity Prediction
The National COVID Cohort Collaborative: Clinical Characterization and Early Severity Prediction Open
Background The majority of U.S. reports of COVID-19 clinical characteristics, disease course, and treatments are from single health systems or focused on one domain. Here we report the creation of the National COVID Cohort Collaborative (N…