Mark Melzer
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View article: Q4ddPCR (May the Fourth Be Precise): A Flexible, 4-Target Assay for High-Resolution HIV Reservoir Profiling
Q4ddPCR (May the Fourth Be Precise): A Flexible, 4-Target Assay for High-Resolution HIV Reservoir Profiling Open
Precise and scalable quantification of the genetically intact HIV reservoir is critical for advancing curative strategies. However, current HIV reservoir assays such as the intact proviral DNA assay (IPDA) are limited by quantification fai…
View article: Disseminated Mycobacterium abscessus with bone and central nervous system (CNS) involvement − a case report and review of the literature
Disseminated Mycobacterium abscessus with bone and central nervous system (CNS) involvement − a case report and review of the literature Open
Background: Mycobacterium abscessus (M.abscessus) is a rapidly growing mycobacterium with intrinsic multidrug resistance. Disseminated disease is usually diagnosed in those patients who are immunocompromised. There is currently limited dat…
View article: Clinical outcomes in OPAT patients treated with ceftriaxone 4 g and ceftazidime 6 g extended interval dosing regimens
Clinical outcomes in OPAT patients treated with ceftriaxone 4 g and ceftazidime 6 g extended interval dosing regimens Open
Background New dosing regimens for ceftriaxone 4 g/24 hours and ceftazidime 3 g/12 hours are convenient for patients receiving OPAT. To date, these have not been clinically validated. Aim To assess the tolerability, toxicity and effectiven…
View article: P106: Continuing the catheter pack quality improvement project
P106: Continuing the catheter pack quality improvement project Open
Background Up to 90,000 patients have a urinary catheter in the community. Although they can be life saving they have been estimated to cost the NHS £1 – 2.5 billion/yr in adverse events. Patient education, as well as ensuring the correct …
View article: Refractory inflammatory bowel disease – Entamoeba histolytica, the forgotten suspect
Refractory inflammatory bowel disease – Entamoeba histolytica, the forgotten suspect Open
Background: Amoebiasis is a term used to describe infection caused by the protozoan Entamoeba histolytica. Transmission is linked to exposure to cysts and trophozoites excreted in the stool. Many infections are asymptomatic, but invasive i…
View article: BI01 Disseminated <i>Nannizziopsis</i> fungal infection in a kidney transplant recipient: iguanas, immunosuppression or international travel?
BI01 Disseminated <i>Nannizziopsis</i> fungal infection in a kidney transplant recipient: iguanas, immunosuppression or international travel? Open
Transplant waiting list demographics are changing profoundly in some parts of the UK, partly due to trends in global migration. This has significant implications for the spectrum of post-transplant skin malignancies and skin infections pre…
View article: Clinical, microbiological characteristics and predictors of mortality in patients with carbapenemase-producing Enterobacterales bloodstream infections: a multicentre study
Clinical, microbiological characteristics and predictors of mortality in patients with carbapenemase-producing Enterobacterales bloodstream infections: a multicentre study Open
Objectives To investigate the microbiological characteristics and clinical outcomes of patients with bloodstream infections (BSI) due to carbapenemase-producing Enterobacterales (CPE). Methods A multicentre retrospective service evaluation…
View article: The utility of a blood culture database to identify patients suitable for outpatient parenteral antibiotic treatment
The utility of a blood culture database to identify patients suitable for outpatient parenteral antibiotic treatment Open
Background The clinical and cost-effectiveness of outpatient parenteral antimicrobial therapy (OPAT) services are well described. We used a blood culture database as a novel approach to case finding and determined its utility in identifyin…