Mark Naccarato
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Intracellular tenofovir‐diphosphate concentrations in <span>HIV</span> pre‐exposure prophylaxis users who underwent bariatric surgery Open
Objective To measure concentrations of tenofovir diphosphate (TFV‐DP) in dried blood spots (DBS) among individuals taking tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC) or tenofovir alafenamide plus emtricitabine (TAF/FTC) who …
View article: High prevalence of syndemic health problems in patients seeking post-exposure prophylaxis for sexual exposures to HIV
High prevalence of syndemic health problems in patients seeking post-exposure prophylaxis for sexual exposures to HIV Open
Introduction The standard clinical approach to non-occupational HIV post-exposure prophylaxis (nPEP) focuses on biomedical aspects of the intervention, but may overlook co-occurring or ‘syndemic’ psychosocial problems that reinforce future…
View article: High prevalence of syndemic health problems in patients seeking post-exposure prophylaxis for sexual exposures to HIV
High prevalence of syndemic health problems in patients seeking post-exposure prophylaxis for sexual exposures to HIV Open
Introduction The standard clinical approach to non-occupational HIV post-exposure prophylaxis (nPEP) focuses on biomedical aspects of the intervention, but may overlook co-occurring or ‘syndemic’ psychosocial problems that reinforce future…
Appropriate usage of post-exposure prophylaxis-in-pocket for HIV prevention by individuals with low-frequency exposures Open
PEP-In-Pocket (Post-Exposure Prophylaxis-In-Pocket, or “PIP”) is a biobehavioural HIV prevention strategy wherein patients are proactively identified and given a prescription for HIV post-exposure prophylaxis (PEP) medications to self-init…
View article: A pharmacist-led interprofessional education program for family practice medical residents specializing in HIV care
A pharmacist-led interprofessional education program for family practice medical residents specializing in HIV care Open
Implication Statement We developed a pharmacist-led one-month teaching rotation for medical residents to learn HIV pharmacotherapy. This interprofessional education (IPE) was deemed extremely valuable by postgraduate-year-3 residents who i…
Treatment‐emergent reverse transcriptase resistance during antiretroviral therapy with bictegravir, tenofovir alafenamide, and emtricitabine: A case series Open
Objectives Bictegravir/tenofovir alafenamide/emtricitabine (BIC/TAF/FTC) is a complete regimen for the treatment of HIV with a high barrier to resistance and few reported cases of treatment failure. We present three cases of treatment‐emer…
Feasibility of implementing a same-day electronic screening tool for clinical assessment to measure patient-reported outcomes for eliciting actionable information on adherence to HIV medication and related factors in a busy Canadian urban HIV clinic Open
Background: An optimal adherence to antiretroviral therapy (ART) is fundamental for suppression of HIV viral load and favourable treatment outcomes. Patient-reported outcomes (PROs) are effective tools for improving patient–provider commun…
The PrEP You Want: A Web-Based Survey of Online Cross-Border Shopping for HIV Prophylaxis Medications Open
Despite high interest in pursuing an online border-crossing approach to get PrEP medications, such an approach may not be a viable option for PrEP scale-up among interested GBMSM because of logistical challenges and perceptions of safety a…
The PrEP You Want: A Web-Based Survey of Online Cross-Border Shopping for HIV Prophylaxis Medications (Preprint) Open
BACKGROUND In response to the high cost of HIV pre-exposure prophylaxis (PrEP) medications in Canada, community organizations have created internet-based guides detailing how to legally order generic medications online and travel to colle…
View article: High prevalence of syndemic health problems in patients seeking post-exposure prophylaxis for sexual exposures to HIV
High prevalence of syndemic health problems in patients seeking post-exposure prophylaxis for sexual exposures to HIV Open
The prevalence of syndemic conditions in MSM seeking nPEP for sexual exposure is alarmingly high, and is associated with underlying HIV risk. Routine screening for these conditions may identify opportunities for intervention and could alle…
Combination Therapy with Tenofovir Disoproxil Fumarate/Emtricitabine/Elvitegravir/Cobicistat Plus Darunavir Once Daily in Antiretroviral-Naive and Treatment-Experienced Patients: A Retrospective Review Open
Background: Patients with drug-resistant HIV often require complex antiretroviral regimens. However, combining fixed-dose combination tablets such as tenofovir–disoproxil–fumarate, emtricitabine, and cobicistat-boosted elvitegravir (TDF/FT…
A Case of a Potential Drug Interaction between Phenobarbital and Darunavir-based Antiretroviral Therapy Open
The cytochrome P450 isoform that is primarily involved in the metabolism of darunavir is CYP3A4. Drugs that modulate this enzyme would then be expected to alter the pharmacokinetics of darunavir.Phenobarbital, a traditional antiepileptic h…