Mark Nagel
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View article: Are the Reference Values for the Provocative Concentration of Methacholine Appropriate for Children?
Are the Reference Values for the Provocative Concentration of Methacholine Appropriate for Children? Open
Background: Preliminary data in a randomly selected pediatric cohort study in 8-year-olds suggested a rate of positivity to a methacholine challenge test that was unexpectedly high, roughly 30%. The current recommendation for…
View article: Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment
Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment Open
View article: P38 Does spacer/adapter device choice affect delivery of a pressurized metered dose inhaler (pMDI) through a humidified circuit to a simulated patient on mechanical ventilation
P38 Does spacer/adapter device choice affect delivery of a pressurized metered dose inhaler (pMDI) through a humidified circuit to a simulated patient on mechanical ventilation Open
Introduction Delivery of aerosolized medication to mechanically ventilated patients is a key element of their treatment. To reduce the risk of infection or derecruitment it is desirable to not break the ventilation circuit. This study eval…
View article: Fiber chromatographic enabled process intensification increases monoclonal antibody product yield
Fiber chromatographic enabled process intensification increases monoclonal antibody product yield Open
The most straightforward method to increase monoclonal antibody (mAb) product yield is to complete the purification process in less steps. Here, three different fiber chromatographic devices were implemented using a holistic approach to in…
View article: HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys
HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys Open
A key challenge for the development of a cure to HIV-1 infection is the persistent viral reservoir established during early infection. Previous studies using Toll-like receptor 7 (TLR7) agonists and broadly neutralizing antibodies (bNAbs) …
View article: 846 Pre-clinical validation of a FLT3L-fusion protein for dendritic cell expansion and anti-tumor efficacy
846 Pre-clinical validation of a FLT3L-fusion protein for dendritic cell expansion and anti-tumor efficacy Open
Background The ligand for the receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) plays an importantrole in hematopoiesis. FLT3 signaling is required for the differentiation andexpansion of dendritic cells. In the context of cancer …
View article: 847 Pharmacokinetics and pharmacodynamics of GS-3583 in cynomolgus monkeys
847 Pharmacokinetics and pharmacodynamics of GS-3583 in cynomolgus monkeys Open
Background The ligand for the receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) plays an importantrole in hematopoiesis. FLT3 signaling is required for the differentiation andexpansion of dendritic cells. In the context of cancer …
View article: 258: Medication delivery of CF drugs via a breath-actuated nebulizer: Review of delivery performance versus a breath-enhanced nebulizer commonly used with such medications
258: Medication delivery of CF drugs via a breath-actuated nebulizer: Review of delivery performance versus a breath-enhanced nebulizer commonly used with such medications Open
View article: DRUG DELIVERY EVALUATION OF A NEW VALVED HOLDING CHAMBER DESIGNED SPECIFICALLY FOR ON-THE-GO USE
DRUG DELIVERY EVALUATION OF A NEW VALVED HOLDING CHAMBER DESIGNED SPECIFICALLY FOR ON-THE-GO USE Open
View article: NIL “Reform” Fails to Address the NCAA’s Biggest Issue
NIL “Reform” Fails to Address the NCAA’s Biggest Issue Open
Do college sport stakeholders have the intellectual and moral courage to abandon the familiar and financially successful, but morally bankrupt and exploitative, collegiate model? The NIL "Reform," which effectively fails to address the NCA…
View article: Effect of Inhalation Patterns on the Delivered Dose of Symbicort™ from a Dry Powder Inhaler Compared to a Metered Dose Inhaler (MDI) Plus Valved Holding Chamber (VHC)
Effect of Inhalation Patterns on the Delivered Dose of Symbicort™ from a Dry Powder Inhaler Compared to a Metered Dose Inhaler (MDI) Plus Valved Holding Chamber (VHC) Open
View article: PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy
PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy Open
Antiretroviral therapy (ART) limits human immunodeficiency virus 1 (HIV-1) replication but does not eliminate the long-lived reservoir established shortly after viral acquisition. A successful HIV cure intervention necessitates either elim…
View article: In vitro and clinical characterization of the valved holding chamber AeroChamber Plus® Flow-Vu® for administrating tiotropium Respimat® in 1–5-year-old children with persistent asthmatic symptoms
In vitro and clinical characterization of the valved holding chamber AeroChamber Plus® Flow-Vu® for administrating tiotropium Respimat® in 1–5-year-old children with persistent asthmatic symptoms Open
The trial was registered under NCT01634113 at http://www.clinicaltrials.gov.
View article: P279 Priming of a non-conducting valved holding chamber (vhc) may result in inconsistent medication delivery
P279 Priming of a non-conducting valved holding chamber (vhc) may result in inconsistent medication delivery Open
Introduction and Objectives Priming VHCs with several actuations of medication before use may be an established practice to prepare the spacer before use. However this practice can have a significant influence on subsequent medication deli…
View article: 168 Combining inhalation by a breath-actuated nebulizer (BAN) and exhalation with oscillating positive expiratory pressure device (OPEP) offers potential for simultaneous therapy: A laboratory study
168 Combining inhalation by a breath-actuated nebulizer (BAN) and exhalation with oscillating positive expiratory pressure device (OPEP) offers potential for simultaneous therapy: A laboratory study Open