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View article: USP8 inhibition regulates autophagy flux and controls Salmonella infection
USP8 inhibition regulates autophagy flux and controls Salmonella infection Open
Introduction Ubiquitination is an important protein modification that regulates various essential cellular processes, including the functions of innate immune cells. Deubiquitinases are enzymes responsible for removing ubiquitin modificati…
View article: Production of chemicals from lignocellulose, biomass or sugars
Production of chemicals from lignocellulose, biomass or sugars Open
The subject invention relates to newly isolated organisms from nature that produce L(+)-lactic acid high yield from hexose and pentose sugars found in biomass. Organisms and processes or methods for the production of lactic acid and other …
View article: Extracellular vesicles elicit protective immune responses against <i>Salmonella</i> infection
Extracellular vesicles elicit protective immune responses against <i>Salmonella</i> infection Open
Small extracellular vesicles (sEVs) produced by antigen‐presenting cells represent a novel mechanism of cell‐to‐cell communication. The sEVs have been shown to drive Th1‐type adaptive immune responses against intracellular infections such …
View article: Fluorescent Labeling of Small Extracellular Vesicles (EVs) Isolated from Conditioned Media
Fluorescent Labeling of Small Extracellular Vesicles (EVs) Isolated from Conditioned Media Open
Extracellular vesicles (EVs), such as exosomes, are produced by all known eukaryotic cells, and constitute essential means of intercellular communication. Recent studies have unraveled the important roles of EVs in migrating to specific si…
View article: Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo
Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo Open
Salmonella Typhimurium is a causative agent of nontyphoidal salmonellosis, for which there is a lack of a clinically approved vaccine in humans. As an intracellular pathogen, Salmonella impacts many cellular pathways. However, the intercel…
View article: An atlas of the catalytically active liver and spleen kinases in chicken identified by chemoproteomics
An atlas of the catalytically active liver and spleen kinases in chicken identified by chemoproteomics Open
Chicken is the first agricultural animal to have a sequenced genome, but current kinase annotations of Gallus gallus are overwhelmingly limited to the predictions generated based on homology or isolated studies focused on specific kinases.…