Mark P. Purdue
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View article: Pre‐diagnostic immunological markers of bacterial translocation and liver cancer risk: A nested case–control analysis of 12 prospective cohorts
Pre‐diagnostic immunological markers of bacterial translocation and liver cancer risk: A nested case–control analysis of 12 prospective cohorts Open
The gut‐liver axis may play an important role in hepatocarcinogenesis. However, limited prospective research has explored associations with liver cancer risk. We conducted a nested case–control study based in 12 prospective cohort studies …
View article: 8287355 Assessing the effectiveness of automatically assigning occupational exposure modules in a multi-center hospital-based case-control study in Asia
8287355 Assessing the effectiveness of automatically assigning occupational exposure modules in a multi-center hospital-based case-control study in Asia Open
View article: Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses
Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses Open
Obesity has been associated with non‐Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B‐cell lymphoma (DLBCL), follic…
View article: Pre-diagnostic circulating bile acid concentrations and liver cancer risk: a nested case-control analysis of 12 cohorts
Pre-diagnostic circulating bile acid concentrations and liver cancer risk: a nested case-control analysis of 12 cohorts Open
Background Bile acids are produced in the liver and are important for lipid digestion. Higher-circulating bile acid levels, however, have been linked to metabolic disorders, inflammation, and gut microbiota dysbiosis, which have been impli…
View article: A case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects
A case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects Open
View article: Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts
Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts Open
In the largest study to date, none of the measured circulating PFAS were associated with liver cancer risk; however, PFOA associations appeared to differ by sex and further research is needed to explore these apparent differences by sex. h…
View article: Coffee and tea consumption and the risk of head and neck cancer: An updated pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
Coffee and tea consumption and the risk of head and neck cancer: An updated pooled analysis in the International Head and Neck Cancer Epidemiology Consortium Open
Introduction The relations between coffee and tea consumption and head and neck cancer (HNC) incidence are unclear. With increasing global HNC burden, this study aims to examine the association between coffee, tea, and HNC. Methods A poole…
View article: Vitamin D binding protein genetic isoforms, serum vitamin D, and cancer risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
Vitamin D binding protein genetic isoforms, serum vitamin D, and cancer risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial Open
Associations between vitamin D biochemical status and cancer may be modified by vitamin D binding protein isoforms which are encoded by GC (group-specific component). We examined interactions between serum 25-hydroxyvitamin D [25(OH)D], th…
View article: Invited Perspective: Insights into Exposure to Industrial Solvents and Cancer Risk at Camp Lejeune
Invited Perspective: Insights into Exposure to Industrial Solvents and Cancer Risk at Camp Lejeune Open
View article: Serum concentrations of per- and polyfluorinated substances and risk of B-cell non-Hodgkin lymphoma
Serum concentrations of per- and polyfluorinated substances and risk of B-cell non-Hodgkin lymphoma Open
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants that are detectable in the serum of most U.S. adults. Some studies of highly-exposed individuals have suggested positive associations between PFAS and B-cell non-…
View article: How well does a single blood sample represent long-term exposure for epidemiological studies of PFOA among men in the general population?
How well does a single blood sample represent long-term exposure for epidemiological studies of PFOA among men in the general population? Open
Many epidemiological studies use a single blood sample per participant to assess exposure, but it is unclear how well a single sample represents longer term exposure. We performed a simulation study using summary statistics for repeated se…
View article: Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma
Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma Open
View article: Mixtures of per- and polyfluoroalkyl substances and testicular germ cell tumor risk in U.S. military personnel: A nested case-control study
Mixtures of per- and polyfluoroalkyl substances and testicular germ cell tumor risk in U.S. military personnel: A nested case-control study Open
View article: A case-control study of early-life residential exposure to perchloroethylene and risks of childhood leukemia and congenital anomalies
A case-control study of early-life residential exposure to perchloroethylene and risks of childhood leukemia and congenital anomalies Open
View article: Serum concentrations of per- and polyfluoroalkyl substances (PFAS) and risk of renal cell carcinoma: Recent findings from prospective cohorts
Serum concentrations of per- and polyfluoroalkyl substances (PFAS) and risk of renal cell carcinoma: Recent findings from prospective cohorts Open
View article: Geographic variation of mutagenic exposures in kidney cancer genomes
Geographic variation of mutagenic exposures in kidney cancer genomes Open
View article: Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers Open
View article: The Mutographs biorepository: A unique genomic resource to study cancer around the world
The Mutographs biorepository: A unique genomic resource to study cancer around the world Open
View article: Associations of per- and polyfluoroalkyl substances and nonalcoholic fatty liver disease in the United States adult population, 2003–2018
Associations of per- and polyfluoroalkyl substances and nonalcoholic fatty liver disease in the United States adult population, 2003–2018 Open
Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide and a leading cause of liver-related mortality. Prior studies have linked per- and polyfluoroalkyl substances (PFAS) exposure to liver dysfunc…
View article: Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project
Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project Open
Background and Aims: Tea and coffee are widely consumed beverages worldwide. We evaluated their association with biliary tract cancer (BTC) incidence. Approach and Results: We pooled data from 15 studies in the Biliary Tract Cancers Poolin…
View article: Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study
Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study Open
View article: Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations
Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations Open
View article: Nested Case–Control Studies Investigating Serum Perfluorooctanoate and Perfluorooctane Sulfonate Levels and Pancreatic Ductal Adenocarcinoma in Two Cohorts
Nested Case–Control Studies Investigating Serum Perfluorooctanoate and Perfluorooctane Sulfonate Levels and Pancreatic Ductal Adenocarcinoma in Two Cohorts Open
View article: Serum concentrations of per- and polyfluoroalkyl substances and risk of renal cell carcinoma in the Multiethnic Cohort Study
Serum concentrations of per- and polyfluoroalkyl substances and risk of renal cell carcinoma in the Multiethnic Cohort Study Open
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations …
View article: A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate Open
View article: Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes Open
View article: Improve the model of disease subtype heterogeneity by leveraging external summary data
Improve the model of disease subtype heterogeneity by leveraging external summary data Open
Researchers are often interested in understanding the disease subtype heterogeneity by testing whether a risk exposure has the same level of effect on different disease subtypes. The polytomous logistic regression (PLR) model provides a fl…
View article: A Nested Case–Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen
A Nested Case–Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen Open
We identified service-related predictors of PFAS concentrations and increased TGCT relative risks with elevated PFOS concentrations among Air Force servicemen. These findings warrant further investigation in other populations and military …
View article: Geographic variation of mutagenic exposures in kidney cancer genomes
Geographic variation of mutagenic exposures in kidney cancer genomes Open
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden 1 . …
View article: Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights
Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights Open