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View article: The development and evaluation of reference materials for Lassa virus molecular diagnostics
The development and evaluation of reference materials for Lassa virus molecular diagnostics Open
Introduction Recent public health emergencies of international concern (PHEIC) have highlighted the need to develop prophylactic treatments and effective diagnostics for pandemic preparedness. In particular, the 100 Days Mission, an initia…
View article: A playbook for harmonization of standards for emergent viral pathogens
A playbook for harmonization of standards for emergent viral pathogens Open
Effective clinical and public health decision-making during a pandemic depends on reliable and interoperable clinical diagnostic test results. To ensure trustworthy outcomes, we need widely available and harmonized calibration standards on…
View article: Standardised quantitative assays for anti-SARS-CoV-2 immune response used in vaccine clinical trials by the CEPI Centralized Laboratory Network: a qualification analysis
Standardised quantitative assays for anti-SARS-CoV-2 immune response used in vaccine clinical trials by the CEPI Centralized Laboratory Network: a qualification analysis Open
CEPI.
View article: The importance of using WHO International Standards to harmonise SARS-CoV-2 serological assays
The importance of using WHO International Standards to harmonise SARS-CoV-2 serological assays Open
The COVID-19 pandemic led to the rapid development of tests to diagnose SARS-CoV-2 infection and ascertain the prevalence of infection, along with the formulation of various treatments and vaccines. Globally, over 220 anti-SARS-CoV-2 serol…
View article: A Playbook for Harmonization of Standards for Emergent Viral Pathogens
A Playbook for Harmonization of Standards for Emergent Viral Pathogens Open
View article: Peritoneal malignancy in the global COVID-19 pandemic: experience of recovery and restoration in a high-volume centre through NHS and independent sector collaboration
Peritoneal malignancy in the global COVID-19 pandemic: experience of recovery and restoration in a high-volume centre through NHS and independent sector collaboration Open
Close collaboration and structural organisation between the clinical and management teams in the NHS and independent sectors facilitated recovery and restoration of a complex tertiary referral service for peritoneal malignancy during the C…
View article: Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP
Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP Open
View article: Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability
Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability Open
View article: Availability and use of Standards in vaccine development
Availability and use of Standards in vaccine development Open
View article: VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display
VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display Open
The hepatitis B core protein (HBc) forms noninfectious virus-like particles, which can be modified to present a capturing molecule, allowing suitably tagged antigens to be bound on their surface. This system can be adapted and provides the…
View article: Standardization and Harmonization of SARS-COV-2 Assays Offered by the CEPI Centralized Laboratory Network in Support for Vaccine Clinical Trials
Standardization and Harmonization of SARS-COV-2 Assays Offered by the CEPI Centralized Laboratory Network in Support for Vaccine Clinical Trials Open
View article: The Coronavirus Standards Working Group’s roadmap for improved population testing
The Coronavirus Standards Working Group’s roadmap for improved population testing Open
View article: Diabetes mellitus, glycaemic control, and severe COVID-19 in the Australian critical care setting: A nested cohort study
Diabetes mellitus, glycaemic control, and severe COVID-19 in the Australian critical care setting: A nested cohort study Open
View article: The experience of UK patients with bladder cancer during the second wave of the COVID‐19 pandemic
The experience of UK patients with bladder cancer during the second wave of the COVID‐19 pandemic Open
The first wave of the COVID-19 pandemic placed unprecedented strains on healthcare systems worldwide, with significant detriment to the routine diagnosis and follow-up of non-COVID patients. For UK bladder cancer (BC) patients, our previou…
View article: VelcroVax: a ‘bolt-on’ vaccine platform technology improves antibody titres against a viral glycoprotein in mice
VelcroVax: a ‘bolt-on’ vaccine platform technology improves antibody titres against a viral glycoprotein in mice Open
Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and to newly emerging pathogens. Virus-like particle (VLP) vaccines form the basis of two of the most successful lic…
View article: Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds
Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds Open
The rise of SARS-CoV-2 variants has made the pursuit to define correlates of protection more troublesome, despite the availability of the World Health Organisation (WHO) International Standard for anti-SARS-CoV-2 Immunoglobulin sera, a key…
View article: Speaking the Same Language: Use of the 1 <sup>st</sup> WHO International SARS-CoV-2 Immunoglobulin Standard to Achieve Comparability Between Commercial SARS-CoV-2 Binding Antibody Assay Readouts
Speaking the Same Language: Use of the 1 <sup>st</sup> WHO International SARS-CoV-2 Immunoglobulin Standard to Achieve Comparability Between Commercial SARS-CoV-2 Binding Antibody Assay Readouts Open
View article: Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study
Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study Open
View article: Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases
Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases Open
Precision monitoring of antibody responses during the COVID-19 pandemic is increasingly important during large scale vaccine rollout and rise in prevalence of Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2) variants of…
View article: A roadmap to better COVID-19 testing from the Coronavirus Standards Working Group
A roadmap to better COVID-19 testing from the Coronavirus Standards Working Group Open
Testing has been central to our response to the COVID-19 pandemic. However, the accuracy of testing relies on standards, including reference materials, proficiency testing schemes, and information and reporting guidelines. The use of stand…
View article: WHO International Standard for evaluation of the antibody response to COVID-19 vaccines: call for urgent action by the scientific community
WHO International Standard for evaluation of the antibody response to COVID-19 vaccines: call for urgent action by the scientific community Open
View article: Neutralisation hierarchy of SARS-CoV-2 Variants of Concern using standardised, quantitative neutralisation assays reveals a correlation with disease severity; towards deciphering protective antibody thresholds
Neutralisation hierarchy of SARS-CoV-2 Variants of Concern using standardised, quantitative neutralisation assays reveals a correlation with disease severity; towards deciphering protective antibody thresholds Open
Background The rise of SARS-CoV-2 variants has made the pursuit to define correlates of protection more troublesome, despite the availability of the World Health Organisation (WHO) International Standard for anti-SARS-CoV-2 Immunoglobulin …
View article: Towards Internationally standardised humoral Immune Correlates of Protection from SARS-CoV-2 infection and COVID-19 disease
Towards Internationally standardised humoral Immune Correlates of Protection from SARS-CoV-2 infection and COVID-19 disease Open
Precision monitoring of antibody responses during the COVID-19 pandemic is increasingly important during large scale vaccine rollout and rise in prevalence of Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2) variants of…
View article: WHO International Standard for anti-SARS-CoV-2 immunoglobulin
WHO International Standard for anti-SARS-CoV-2 immunoglobulin Open
View article: Rapid Translation of COVID-19 Preprint Data into Critical Care Practice
Rapid Translation of COVID-19 Preprint Data into Critical Care Practice Open
To the Editor:\nThe global coronavirus disease (COVID-19) pandemic has seen a significant increase in the use of preprint services to enable the widespread dissemination of research findings (1). However, whether such facilities influence …
View article: Evaluation of a serological reference panel for Lassa virus
Evaluation of a serological reference panel for Lassa virus Open
View article: The experience of UK patients with bladder cancer during the COVID‐19 pandemic: a survey‐based snapshot
The experience of UK patients with bladder cancer during the COVID‐19 pandemic: a survey‐based snapshot Open
The COVID-19 pandemic has placed unprecedented strain on healthcare systems worldwide with the requirement to treat large influxes of infected patients, many of whom require respiratory support. Healthcare systems have had to redirect reso…
View article: Author Correction: Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination
Author Correction: Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination Open
View article: Passive immunisation of convalescent human anti-Zika plasma protects against challenge with New World Zika virus in cynomolgus macaques
Passive immunisation of convalescent human anti-Zika plasma protects against challenge with New World Zika virus in cynomolgus macaques Open
Zika virus (ZIKV) causes neurological complications in susceptible individuals, highlighted in the recent South American epidemic. Natural ZIKV infection elicits host responses capable of preventing subsequent re-infection, raising expecta…
View article: THE EXPERIENCE OF UK BLADDER CANCER PATIENTS DURING THE COVID-19 PANDEMIC: A SURVEY-BASED SNAPSHOT
THE EXPERIENCE OF UK BLADDER CANCER PATIENTS DURING THE COVID-19 PANDEMIC: A SURVEY-BASED SNAPSHOT Open
The Covid-19 pandemic has placed unprecedented strain on healthcare systems worldwide. Within this context, UK cancer services have undergone significant disruption to create capacity for the National Health Service. As a charity that ende…