Mark Parta
YOU?
Author Swipe
View article: Intermediate-dose posttransplantation cyclophosphamide for myeloablative HLA-haploidentical bone marrow transplantation
Intermediate-dose posttransplantation cyclophosphamide for myeloablative HLA-haploidentical bone marrow transplantation Open
High-dose posttransplantation cyclophosphamide (HD-PTCy), given at 50 mg/kg/day on days +3/+4, is a standard-of-care graft-versus-host disease (GVHD) prophylaxis for allogeneic hematopoietic cell transplantation (HCT). Our murine MHC–haplo…
View article: Outcomes in hematopoetic cell transplantation in the setting of mold infections in patients with chronic granulomatous disease
Outcomes in hematopoetic cell transplantation in the setting of mold infections in patients with chronic granulomatous disease Open
Chronic granulomatous disease (CGD) is a disorder of immunity characterized by phagocyte dysfunction. Mold infections in patients with CGD are often severe and disseminated. We present patient characteristics, microbiological data, and out…
View article: Human papillomavirus disease in GATA2 deficiency: a genetic predisposition to HPV-associated female anogenital malignancy
Human papillomavirus disease in GATA2 deficiency: a genetic predisposition to HPV-associated female anogenital malignancy Open
Objective Patients with pathogenic variants in the GATA Binding Protein 2 ( GATA2 ), a hematopoietic transcription factor, are at risk for human papillomavirus-related (HPV) anogenital cancer at younger than expected ages. A female cohort …
View article: S10.5d Disseminated pulmonary infection due to <i>Mortierella wolfii</i> in a 6-year-old patient with X-linked CGD receiving MUD-HSCT
S10.5d Disseminated pulmonary infection due to <i>Mortierella wolfii</i> in a 6-year-old patient with X-linked CGD receiving MUD-HSCT Open
S10.5 Fungal respiratory infections in Cystic Fibrosis, September 24, 2022, 10:30 AM - 12:00 PM Objectives Invasive fungal infections represent one of the major limiting factors for the successful outcome of patients receiving hematopoieti…
View article: Febrile neutropenia management and outcomes in hematopoietic cell transplantation for chronic granulomatous disease
Febrile neutropenia management and outcomes in hematopoietic cell transplantation for chronic granulomatous disease Open
Objective We analyzed events and therapies related to febrile neutropenia in patients receiving hematopoietic cell transplantation (HCT) for chronic granulomatous disease (CGD). Methods Three protocols for HCT were used to extract the rela…
View article: Donor source and post‐transplantation cyclophosphamide influence outcome in allogeneic stem cell transplantation for GATA2 deficiency
Donor source and post‐transplantation cyclophosphamide influence outcome in allogeneic stem cell transplantation for GATA2 deficiency Open
Summary GATA2 deficiency was described in 2011, and shortly thereafter allogeneic hematopoietic stem cell transplantation (HSCT) was shown to reverse the hematologic disease phenotype. However, there remain major unanswered questions regar…
View article: Late-onset X-linked Chronic Granulomatous Disease in a Female Carrier: Therapeutic Role of Interferon-γ and Hematopoietic Stem Cell Transplantation
Late-onset X-linked Chronic Granulomatous Disease in a Female Carrier: Therapeutic Role of Interferon-γ and Hematopoietic Stem Cell Transplantation Open
X-linked Chronic Granulomatous Disease (CGD) is a rare inherited immunodeficiency characterized by early life-threatening infections from bacteria and fungi in male children. Female carriers of X-linked CGD usually do not develop any manif…
View article: BK Virus-Associated Hemorrhagic Cystitis in Allogeneic Hematopoietic Cell Transplantation (HCT) Recipients with Primary Immunodeficiency
BK Virus-Associated Hemorrhagic Cystitis in Allogeneic Hematopoietic Cell Transplantation (HCT) Recipients with Primary Immunodeficiency Open
Allogeneic HCT recipients may develop BK virus (BKV)-associated hemorrhagic cystitis (BKV-HC), typically early after engraftment. Yet, BKV levels in urine and blood are not routinely monitored pre- or post-HCT. Among HCT recipients with pr…
View article: 1689. Active, Invasive Fungal Infection, and Hematopoietic Cell Transplantation (HCT) in Chronic Granulomatous Disease (CGD): Presentation, Procedure, and Outcomes
1689. Active, Invasive Fungal Infection, and Hematopoietic Cell Transplantation (HCT) in Chronic Granulomatous Disease (CGD): Presentation, Procedure, and Outcomes Open
Background Individuals with CGD develop invasive fungal infections which are often refractory to medical therapy. Disease caused by Aspergillus nidulans (An), Scedosporium apiospermum (Sa), and Aspergillus viridinutans (Av), can be fatal d…
View article: Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection
Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection Open
Antimicrobial resistance in bacteria represents one of the most consequential problems in modern medicine, and its emergence and spread threaten to compromise central advances in the treatment of infectious diseases. Ceftazidime-avibactam …
View article: Case Report: Ocular toxoplasmosis in a WHIM syndrome immunodeficiency patient
Case Report: Ocular toxoplasmosis in a WHIM syndrome immunodeficiency patient Open
A patient with WHIM syndrome immunodeficiency presented with sudden painless right eye blindness associated with advanced retinal and optic nerve damage. Toxoplasma gondii was detected by PCR in vitreous fluid but not serum. The patient wa…
View article: Tandem Orthotopic Living Donor Liver Transplantation Followed by Same Donor Haploidentical Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency
Tandem Orthotopic Living Donor Liver Transplantation Followed by Same Donor Haploidentical Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency Open
Background. An 11-year-old girl with dedicator of cytokinesis 8 (DOCK8) deficiency was proposed for potentially curative hematopoietic stem cell transplantation (HSCT), the donor being her haploidentical mother. However, end-stage liver di…
View article: Successful Allogeneic Hematopoietic Cell Transplantation (HCT) with Low Toxicity and Gvhd in a Heterogeneous Cohort of Primary Immunodeficiency (PID) Patients
Successful Allogeneic Hematopoietic Cell Transplantation (HCT) with Low Toxicity and Gvhd in a Heterogeneous Cohort of Primary Immunodeficiency (PID) Patients Open
HCT has been used for decades as a definitive therapy for patients with PIDs. These patients often enter HCT with significant comorbidities and disease sequelae and may have limited donor options if family members are also affected, so the…
View article: Case Report: Ocular toxoplasmosis in a WHIM syndrome immunodeficiency patient
Case Report: Ocular toxoplasmosis in a WHIM syndrome immunodeficiency patient Open
A patient with WHIM syndrome immunodeficiency presented with sudden painless right eye blindness associated with advanced retinal and optic nerve damage. Toxoplasma gondii was detected by PCR in vitreous fluid but not serum. The patient wa…
View article: Donor-derived MDS/AML in families with germline GATA2 mutation
Donor-derived MDS/AML in families with germline GATA2 mutation Open
TO THE EDITOR:
GATA2 encodes a zinc-finger transcription factor that is required for proliferation and survival of hematopoietic stem cells.[1][1] First described in 2011, germline heterozygous mutations in GATA2 lead to haploinsufficienc…
Emerging Aspergillus Species Almost Exclusively Associated With Primary Immunodeficiencies Open
Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspe…