Mark Perelis
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View article: Integrative CRISPR Screening and RNA Analyses Discover an Essential Role for PUF60 Interactions with 3' Splice Sites in Cancer Progression
Integrative CRISPR Screening and RNA Analyses Discover an Essential Role for PUF60 Interactions with 3' Splice Sites in Cancer Progression Open
RNA-binding proteins (RBPs) are important regulators of post-transcriptional gene expression. Understanding which and how RBPs promote cancer progression is crucial for cancers that lack effective targeted therapies, such as triple negativ…
OR21-07 Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis Open
Disclosure: I. Sakuma: None. R.C. Gaspar: None. Y. Taki: None. M. Perelis: None. M.W. Roden: None. T. Tanaka: None. G.I. Shulman: None. Context: Metabolic dysfunction-associated steatohepatitis (MASH) represents a progressive form of steat…
View article: Human CCR4 deadenylase homolog Angel1 is a non-stop mRNA decay factor
Human CCR4 deadenylase homolog Angel1 is a non-stop mRNA decay factor Open
Translation elongation stalls trigger mRNA decay and degradation of the nascent polypeptide via translation-dependent quality control pathways. One such pathway, non-stop mRNA decay (NSD), targets aberrant mRNAs that lack stop codons, for …
View article: Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3’ Splice Site Interactions in Cancer Progression
Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3’ Splice Site Interactions in Cancer Progression Open
RNA-binding proteins (RBPs) are important regulators of post-transcriptional gene expression. Understanding which and how RBPs promote cancer progression is crucial for cancers that lack effective targeted therapies such as triple negative…
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis Open
Metabolic dysfunction–associated steatohepatitis (MASH) represents a progressive form of steatotic liver disease which increases the risk for fibrosis and advanced liver disease. The accumulation of discrete species of bioactive lipids has…
View article: Stratification of enterochromaffin cells by single-cell expression analysis
Stratification of enterochromaffin cells by single-cell expression analysis Open
Dynamic interactions between gut mucosal cells and the external environment are essential to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and mechanical signals and produce 5-hydroxytryptamine to mediate di…
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis Open
Metabolic dysfunction-associated steatohepatitis (MASH) represents a progressive form of steatotic liver disease which increases the risk for fibrosis and advanced liver disease. The accumulation of discrete species of bioactive lipids has…
View article: Stratification of enterochromaffin cells by single-cell expression analysis
Stratification of enterochromaffin cells by single-cell expression analysis Open
Dynamic interactions between gut mucosal cells and the external environment are essential to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and mechanical signals and produce 5-hydroxytryptamine (5-HT) to med…
Stratification of enterochromaffin cells by single-cell expression analysis Open
Dynamic interactions between gut mucosal cells and the external environment are essential to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and mechanical signals and produce 5-hydroxytryptamine to mediate di…
Stratification of enterochromaffin cells by single-cell expression analysis Open
Dynamic interactions between gut mucosal cells and the external environment are essential to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and mechanical signals and produce 5-hydroxytryptamine (5-HT) to med…
Stratification of enterochromaffin cells by single-cell expression analysis Open
Dynamic interactions between gut mucosal cells and the external environment are essential to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and mechanical signals and produce 5-hydroxytryptamine (5-HT) to med…
Human CCR4 deadenylase homolog Angel1 is a Non-Stop mRNA Decay factor Open
Translation elongation stalls trigger mRNA decay and degradation of the nascent polypeptide via translation-dependent quality control pathways. One such pathway, non-stop mRNA decay (NSD), targets aberrant mRNAs that lack stop codons for e…
Author response: P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The mamma…
Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen Open
Summary The mammalian circadian clock drives daily oscillations in physiology and behavior through an autoregulatory transcription feedback loop present in central and peripheral cells. Ablation of the core clock within the endocrine pancr…
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer Open
RNA-binding proteins (RBPs) are critical regulators of post-transcriptional gene expression, and aberrant RBP-RNA interactions can promote cancer progression. Here, we interrogate the function of RBPs in cancer using pooled CRISPR-Cas9 scr…
A role for alternative splicing in circadian control of exocytosis and glucose homeostasis Open
The circadian clock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior through molecular programs that remain incompletely understood. Here, we reveal rhythmic genome-wide alternative splicing (…
Cryptochromes-mediated Inhibition of the CRL4 <sup>Cop1</sup> -Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism Open
In plants, Cryptochromes are photoreceptors that negatively regulate CRL4 Cop1 (Cul4-RING ubiquitin ligase and its substrate receptor Cop1). In mammals, Cryptochromes are core components of the circadian clock and repressors of the glucoco…
Requirement for NF-κB in maintenance of molecular and behavioral circadian rhythms in mice Open
The mammalian circadian clock is encoded by an autoregulatory transcription feedback loop that drives rhythmic behavior and gene expression in the brain and peripheral tissues. Transcriptomic analyses indicate cell type-specific effects of…
Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning Open
The transcription factor encoded by the Pdx1 gene is a critical transcriptional regulator, as it has fundamental actions in the formation of all pancreatic cell types, islet β-cell development, and adult islet β-cell function. Transgenic- …
Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology Open
The mammalian circadian clock plays a central role in the temporal coordination of physiology across the 24-h light-dark cycle. A major function of the clock is to maintain energy constancy in anticipation of alternating periods of fasting…