Mark Pimentel
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View article: Lessons learned from physician-performed high-resolution esophageal manometries
Lessons learned from physician-performed high-resolution esophageal manometries Open
Summary High-resolution esophageal manometry (HRM) is the gold standard test for evaluation and diagnosis of esophageal motility disorders. While the Chicago Classification offers a standardized protocol for performing and interpreting HRM…
View article: Relationship Between Hypothyroidism, Risk of Small Intestinal Bacterial Overgrowth, and Duodenal Microbiome Alterations
Relationship Between Hypothyroidism, Risk of Small Intestinal Bacterial Overgrowth, and Duodenal Microbiome Alterations Open
Context There is an association between hypothyroidism and small intestinal bacterial overgrowth (SIBO), but the exact mechanistic link between these 2 conditions is not fully elucidated. Objective We evaluate the incidence and risks of su…
View article: The Safety of Pharmacotherapy for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
The Safety of Pharmacotherapy for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis Open
INTRODUCTION: Understanding the safety of pharmacotherapy for irritable bowel syndrome (IBS) enables individuals to make informed treatment decisions. While many studies include the number needed to treat to highlight therapeutic benefits,…
View article: Tracking Anti-cytolethal Distending Toxin B and Anti-vinculin Over Time and Their Roles in Symptoms
Tracking Anti-cytolethal Distending Toxin B and Anti-vinculin Over Time and Their Roles in Symptoms Open
Anti-CdtB and anti-vinculin antibodies are common in post-infection IBS, and anti-vinculin levels may correlate with severity of IBS symptoms.
View article: Third generation sequencing analysis detects significant differences in duodenal microbiome composition between functional dyspepsia patients and control subjects
Third generation sequencing analysis detects significant differences in duodenal microbiome composition between functional dyspepsia patients and control subjects Open
Background Functional dyspepsia (FD) is a multifactorial disorder as its development may be based on several different pathophysiological mechanisms. Interaction of gut microbiome with the host has been proposed as a potential mechanism in…
View article: SUN-477 The Gut Microbe Rothia Mucilaginosa Induces a Polycystic Ovarian Syndrome-Like Phenotype in a Rat Model
SUN-477 The Gut Microbe Rothia Mucilaginosa Induces a Polycystic Ovarian Syndrome-Like Phenotype in a Rat Model Open
G. Parodi: None. R. de Souza Santos: None. G. Leite: None. F. Medeiros: None. G.M. Barlow: None. W. Morales: None. S.R. Weitsman: None. M. Sanchez: None. I. Rivera: None. M. Villanueva-Millan: None. F. Faria: None. D. Flor: None. L. Choi: …
View article: 7964 Manipulation of the Gut Microbiome Using Antibiotics Is Associated With Sex-Specific Reductions in Systemic Testosterone Levels in Rats
7964 Manipulation of the Gut Microbiome Using Antibiotics Is Associated With Sex-Specific Reductions in Systemic Testosterone Levels in Rats Open
Disclosure: G. Parodi: None. G. Leite: None. W. Morales: None. S.R. Weitsman: None. G.M. Barlow: None. M. Sanchez: None. M. Pimentel: None. M. Villanueva-Millan: None. M. Pimentel: None. R. Mathur: None. The gut microbiome has impacts on m…
View article: 7964 Manipulation of the Gut Microbiome Using Antibiotics Is Associated With Sex-Specific Reductions in Systemic Testosterone Levels in Rats
7964 Manipulation of the Gut Microbiome Using Antibiotics Is Associated With Sex-Specific Reductions in Systemic Testosterone Levels in Rats Open
Disclosure: G. Parodi: None. G. Leite: None. W. Morales: None. S.R. Weitsman: None. G.M. Barlow: None. M. Sanchez: None. M. Pimentel: None. M. Villanueva-Millan: None. M. Pimentel: None. R. Mathur: None. The gut microbiome has impacts on m…
View article: Food Retention at Endoscopy Among Adults Using Glucagon-Like Peptide-1 Receptor Agonists
Food Retention at Endoscopy Among Adults Using Glucagon-Like Peptide-1 Receptor Agonists Open
This cross-sectional study investigates the association between glucagon-like peptide-1 receptor agonists and food retention during esophagogastroduodenoscopy.
View article: Low dose rifaximin combined with N-acetylcysteine is superior to rifaximin alone in a rat model of IBS-D: a randomized trial
Low dose rifaximin combined with N-acetylcysteine is superior to rifaximin alone in a rat model of IBS-D: a randomized trial Open
Rifaximin is FDA-approved for treatment of irritable bowel syndrome with diarrhea (IBS-D), but poor solubility may limit its efficacy against microbes in the mucus layer, e.g. Escherichia coli. Here we evaluate adding the mucolytic N-acety…
View article: Prevalence of small intestinal bacterial overgrowth in intestinal failure syndrome: A systematic review and meta‐analysis
Prevalence of small intestinal bacterial overgrowth in intestinal failure syndrome: A systematic review and meta‐analysis Open
Background and Aim Patients with intestinal failure (IF) have abnormal intestinal anatomy, secretion, and dysmotility, which impairs intestinal homeostatic mechanisms and may lead to small intestinal bacterial overgrowth (SIBO). We conduct…
View article: Editorial: Cross-boundary significance of methanogens - the methane moment and beyond
Editorial: Cross-boundary significance of methanogens - the methane moment and beyond Open
Zhe Lyu1*Amelia-Elena Rotaru2Mark Pimentel3Cui-Jing Zhang4Simon K.-M. R. Rittmann5,6James G. Ferry7*
View article: Extracellular and intracellular antiviral effects of ultraviolet A against severe acute respiratory syndrome coronavirus-2 are variant-independent
Extracellular and intracellular antiviral effects of ultraviolet A against severe acute respiratory syndrome coronavirus-2 are variant-independent Open
Narrow-band UVA exhibits both extracellular effects on SARS-CoV-2 viral particles and intracellular effects on infected cells with SARS-CoV-2. Efficacy appears to be variant independent.
View article: Characterization of the Small Bowel Microbiome Reveals Different Profiles in Human Subjects Who Are Overweight or Have Obesity
Characterization of the Small Bowel Microbiome Reveals Different Profiles in Human Subjects Who Are Overweight or Have Obesity Open
INTRODUCTION: Gut microbiome changes are linked to obesity, but findings are based on stool data. In this article, we analyzed the duodenal microbiome and serum biomarkers in subjects with normal weight, overweight, and obesity. METHODS: D…
View article: Antifungal effects of echinocandins diminish when exposed to intestinal lumen contents: a finding with potentially significant clinical implications
Antifungal effects of echinocandins diminish when exposed to intestinal lumen contents: a finding with potentially significant clinical implications Open
Echinocandins, a prominent class of antifungals, are known for their broad-spectrum activity and favorable safety profiles. However, their bioavailability and efficacy via oral route are suboptimal. In this study, caspofungin and micafungi…
View article: Symptomatic Response to Antibiotics in Patients With Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-analysis
Symptomatic Response to Antibiotics in Patients With Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-analysis Open
Antibiotics appear to be efficacious in treating SIBO, although small sample sizes and poor data quality limit this interpretation. Symptomatic response rates also appear to be higher in IBS patients with SIBO. This may be the first exampl…
View article: Obesity and Beyond: The Novel Technical Standard to Study the Small Bowel Microbiome
Obesity and Beyond: The Novel Technical Standard to Study the Small Bowel Microbiome Open
The small intestinal microbiome (SIM) is colonized by a variety of bacteria, archaea, viruses, and eukarya which contribute to the overall health of the human host. Commensal bacteria of the small intestine are crucial suppliers of essenti…
View article: Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model
Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model Open
Diarrhea-predominant irritable bowel syndrome (IBS-D), associated with increased intestinal permeability, inflammation, and small intestinal bacterial overgrowth, can be triggered by acute gastroenteritis. Cytolethal distending toxin B (Cd…
View article: Improvements in Digestive Symptoms After Participation in an App-Based Chronic Digestive Disease Management Program: Prospective Cohort Evaluation (Preprint)
Improvements in Digestive Symptoms After Participation in an App-Based Chronic Digestive Disease Management Program: Prospective Cohort Evaluation (Preprint) Open
BACKGROUND Gastrointestinal (GI) conditions account for 105 million ambulatory care visits, 14 million hospital admissions, 236,000 deaths, and $142 billion in total costs in the U.S. annually. Historically, less than 20% of adults with c…
View article: SAT371 Gavaging Adult Female Rats with Rothia sp. Leads to Profound Disruption of the Estrous Cycles and Metabolic Consequences
SAT371 Gavaging Adult Female Rats with Rothia sp. Leads to Profound Disruption of the Estrous Cycles and Metabolic Consequences Open
Disclosure: R. Santos: None. G. Parodi: None. G. Leite: None. W. Morales: None. S.R. Weitsman: None. G. Barlow: None. I. Rivera: None. M. Sanchez: None. D. Flor: None. L. Choi: None. S.L. Gonzales: None. F. Faria: None. M. Villanueva-Milla…
View article: THU076 GH, IGF-1 And Inflammatory Marker Interactions With Small Bowel Microbial Diversity Are Age And Sex Dependent
THU076 GH, IGF-1 And Inflammatory Marker Interactions With Small Bowel Microbial Diversity Are Age And Sex Dependent Open
Disclosure: G. Leite: None. N. Tal: None. G. Barlow: None. W. Morales: None. R. de Souza Santos: None. M. Rashid: None. A. Hosseini: None. M. Pimentel: None. R. Mathur: None. Attenuated somatotroph axis function correlates inversely with a…
View article: THU075 Sex And Age Specificity Of Correlations Among IGF-1, GH, And Duodenal Microbial Diversity Predicting TMA Biosynthesis
THU075 Sex And Age Specificity Of Correlations Among IGF-1, GH, And Duodenal Microbial Diversity Predicting TMA Biosynthesis Open
Disclosure: N. Tal: None. G. Leite: None. G. Barlow: None. W. Morales: None. R. de Souza Santos: None. M. Pimentel: None. R. Mathur: None. Varied gut microbial profiles and functional potentials may increase or decrease cardiovascular (CVD…
View article: Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in inflammatory bowel disease patients
Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in inflammatory bowel disease patients Open
Background Despite adequate treatment, a subgroup of patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, have persistent gastrointestinal symptoms that are not always related to mucosal damage.…
View article: Defining Small Intestinal Bacterial Overgrowth by Culture and High Throughput Sequencing
Defining Small Intestinal Bacterial Overgrowth by Culture and High Throughput Sequencing Open
Our findings confirm ≥103 CFU/mL is the optimal SIBO threshold, associated with gastrointestinal symptoms, significantly decreased microbial diversity, and network disruption. Microbial hydrogen- and hydrogen sulfide-related pathways were …
View article: Antivinculin Antibodies in Systemic Sclerosis: Associations With Slow Gastric Transit and Extraintestinal Clinical Phenotype
Antivinculin Antibodies in Systemic Sclerosis: Associations With Slow Gastric Transit and Extraintestinal Clinical Phenotype Open
Objective The gastrointestinal (GI) tract is commonly affected in systemic sclerosis (SSc). A positive association between antivinculin antibody levels and GI symptom severity is reported in SSc. We sought to examine whether antivinculin a…