Mark R. Gilbert
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View article: IMMU-82. Neuronal modulation of immunity in glioblastoma
IMMU-82. Neuronal modulation of immunity in glioblastoma Open
Recent studies determined that in glioblastoma, tumor cells integrate into neural networks, forming synapses with neurons, enhancing neuronal firing facilitating tumor growth. We sought to understand how neuronal activity alters the functi…
View article: 1200 Tumor-specific resident memory-like T cells induced by viral vector vaccination mediate protection against orthotopic murine glioblastoma
1200 Tumor-specific resident memory-like T cells induced by viral vector vaccination mediate protection against orthotopic murine glioblastoma Open
View article: Variability in Insurance Coverage for Adult Voice Therapy in The United States of America
Variability in Insurance Coverage for Adult Voice Therapy in The United States of America Open
Objectives Voice therapy is often the first‐line treatment and an adjunct to medical or surgical management of dysphonia. However, a minority of patients with dysphonia utilize voice therapy. Insurance coverage can affect patients' decisio…
View article: Supplemental Table 2 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma
Supplemental Table 2 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma Open
Cell line panel profiles.
View article: Supplemental Figure 2 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma
Supplemental Figure 2 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma Open
Pathway enrichment analysis of carmustine-sensitive versus carmustine-resistant cell lines.
View article: Data from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma
Data from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma Open
Patients with malignant gliomas with methylated MGMT promoters are generally more sensitive to alkylating chemotherapy as this modification impedes DNA repair. However, inconsistencies in the predictive accuracy of MGMT promo…
View article: Supplemental Figure 1 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma
Supplemental Figure 1 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma Open
Expression of MGMT in the brain cell lines included in the NCI-60.
View article: Supplemental Table 1 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma
Supplemental Table 1 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma Open
Evaluation of the combined contribution of MGMT promoter and body methylation to mRNA and protein expression and carmustine sensitivity.
View article: Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions Open
Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021, the World Health Organization updated the classification of Central Nervous System (CNS) tumors to restrict gliobl…
View article: Cost of the GetCheckedOnline digital testing program: Micro-costing analysis
Cost of the GetCheckedOnline digital testing program: Micro-costing analysis Open
GetCheckedOnline.com (GCO) is a digital sexually transmitted and blood-borne infection (STBBI) testing service provided in British Columbia, Canada. Using a micro-costing approach, we calculated the costs during the planning, development a…
View article: <scp>cIMPACT</scp>‐<scp>NOW</scp> update 10: Recommendations for defining new types for central nervous system tumor classification
<span>cIMPACT</span>‐<span>NOW</span> update 10: Recommendations for defining new types for central nervous system tumor classification Open
View article: Establishing the content validity of patient-reported outcome measures used in neuro-oncology based on the WHO ICF framework: Part of the RANO-PRO initiative
Establishing the content validity of patient-reported outcome measures used in neuro-oncology based on the WHO ICF framework: Part of the RANO-PRO initiative Open
Background Instruments to assess patient-reported outcomes (PRO) should generate high-quality evidence. Reliable PRO evidence is essential to policymakers, in conjunction with outcomes such as survival and radiological response, to underst…
View article: Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib
Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib Open
View article: Characterization of MAIT cells in glioblastoma reveals a potential immunosuppressive role through a MAIT-neutrophil axis
Characterization of MAIT cells in glioblastoma reveals a potential immunosuppressive role through a MAIT-neutrophil axis Open
Background Glioblastoma (GBM) is the most aggressive primary brain cancer in adults and remains incurable. Mucosal-associated invariant T (MAIT) cells are unconventional T cells with a semi-invariant T cell receptor and have been shown to …
View article: Neighborhood disadvantage is associated with treatment access outcomes and survival among individuals with a primary brain tumor
Neighborhood disadvantage is associated with treatment access outcomes and survival among individuals with a primary brain tumor Open
Background Neighborhood disadvantage is linked to lower rates of healthcare access. To understand how residence affects the primary brain tumor (PBT) population, we assessed neighborhood disadvantage and population density with treatment a…
View article: Disparities in the availability of and access to neuro-oncology trial-supporting infrastructure in the United States
Disparities in the availability of and access to neuro-oncology trial-supporting infrastructure in the United States Open
We conducted an extensive assessment and quantification of the reach of the oncology clinical trial-supporting infrastructure in the United States. Although our primary focus was on identifying avenues to expand the reach of neuro-oncology…
View article: HOXD12 defines an age-related aggressive subtype of oligodendroglioma
HOXD12 defines an age-related aggressive subtype of oligodendroglioma Open
View article: cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas
cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas Open
Meningiomas are the most frequent primary intracranial tumors. Hence, they constitute a major share of diagnostic specimens in neuropathology practice. The 2021 WHO Classification of Central Nervous System Tumors (“CNS5”) has introduced th…
View article: Distinct relapse pattern across molecular ependymoma types
Distinct relapse pattern across molecular ependymoma types Open
Background Ependymoma (EPN) is not a uniform disease but represents different disease types with biological and clinical heterogeneity. However, the pattern of when and where different types of EPN relapse is not yet comprehensively descri…
View article: Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence
Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence Open
Despite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore, exploring the effect of mutations on p53 isoforms activities is a critical, albeit unexplored are…
View article: A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults Open
Radiographic assessment plays a crucial role in the management of patients with central nervous system (CNS) tumors, aiding in treatment planning and evaluation of therapeutic efficacy by quantifying response. Recently, an updated version …
View article: PLX038A, a long-acting SN-38, penetrates the blood-tumor-brain-barrier, accumulates and releases SN-38 in brain tumors to increase survival of tumor bearing mice
PLX038A, a long-acting SN-38, penetrates the blood-tumor-brain-barrier, accumulates and releases SN-38 in brain tumors to increase survival of tumor bearing mice Open
Central nervous system tumors have resisted effective chemotherapy because most therapeutics do not penetrate the blood-tumor-brain-barrier. Nanomedicines between ~ 10 and 100 nm accumulate in many solid tumors by the enhanced permeability…
View article: EPEN-01. DISTINCT RELAPSE PATTERN ACROSS MOLECULAR EPENDYMOMA TYPES
EPEN-01. DISTINCT RELAPSE PATTERN ACROSS MOLECULAR EPENDYMOMA TYPES Open
BACKGROUND Ependymoma (EPN) is not a uniform disease but represents different tumor types with biological and clinical heterogeneity. Some types have an excellent prognosis; others display frequent relapse. However, the pattern of when and…
View article: Raman-based machine-learning platform reveals unique metabolic differences between IDHmut and IDHwt glioma
Raman-based machine-learning platform reveals unique metabolic differences between IDHmut and IDHwt glioma Open
Background Formalin-fixed, paraffin-embedded (FFPE) tissue slides are routinely used in cancer diagnosis, clinical decision-making, and stored in biobanks, but their utilization in Raman spectroscopy-based studies has been limited due to t…
View article: Cysteamine Suppresses Cancer Cell Invasion and Migration in Glioblastoma through Inhibition of Matrix Metalloproteinase Activity
Cysteamine Suppresses Cancer Cell Invasion and Migration in Glioblastoma through Inhibition of Matrix Metalloproteinase Activity Open
Glioblastoma (GBM) cells are highly invasive, infiltrating the surrounding normal brain tissue, thereby limiting the efficacy of surgical resection and focal radiotherapy. Cysteamine, a small aminothiol molecule that is orally bioavailable…
View article: Radiotherapy Plan Quality Assurance in NRG Oncology Trials for Brain and Head/Neck Cancers: An AI-Enhanced Knowledge-Based Approach
Radiotherapy Plan Quality Assurance in NRG Oncology Trials for Brain and Head/Neck Cancers: An AI-Enhanced Knowledge-Based Approach Open
The quality of radiation therapy (RT) treatment plans directly affects the outcomes of clinical trials. KBP solutions have been utilized in RT plan quality assurance (QA). In this study, we evaluated the quality of RT plans for brain and h…
View article: Assessing sleep in primary brain tumor patients using smart wearables and patient-reported data: Feasibility and interim analysis of an observational study
Assessing sleep in primary brain tumor patients using smart wearables and patient-reported data: Feasibility and interim analysis of an observational study Open
Background Sleep–wake disturbances are common and disabling in primary brain tumor (PBT) patients but studies exploring longitudinal data are limited. This study investigates the feasibility and relationship between longitudinal patient-re…
View article: Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors
Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors Open
Purpose Multidisciplinary tumor boards (MTBs) integrate clinical, molecular, and radiological information and facilitate coordination of neuro-oncology care. During the COVID-19 pandemic, our MTB transitioned to a virtual and multi-institu…
View article: Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype Open
Glioblastoma is universally fatal and characterized by frequent chromosomal copy number alterations harboring oncogenes and tumor suppressors. In this study, we analyzed exome-wide human glioblastoma copy number data and found that cytoban…
View article: rWTC‐MBTA Vaccine Induces Potent Adaptive Immune Responses Against Glioblastomas via Dynamic Activation of Dendritic Cells
rWTC‐MBTA Vaccine Induces Potent Adaptive Immune Responses Against Glioblastomas via Dynamic Activation of Dendritic Cells Open
Despite strides in immunotherapy, glioblastoma multiforme (GBM) remains challenging due to low inherent immunogenicity and suppressive tumor microenvironment. Converting “cold” GBMs to “hot” is crucial for immune activation and improved ou…