Christon J. Hurst
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View article: Two transcription factors and one antisense RNA underlie the thermoregulated insect pathogenicity of Yersinia entomophaga MH96
Two transcription factors and one antisense RNA underlie the thermoregulated insect pathogenicity of Yersinia entomophaga MH96 Open
Entomopathogenic bacteria express virulence genes in a temperature-dependent manner, but the underlying molecular mechanisms remain poorly understood. Here, we describe the roles of an unusual LytTR-containing transcription factor Yen6 in …
View article: Microbial dynamics across tri-trophic systems: insights from plant–herbivore–predator interactions
Microbial dynamics across tri-trophic systems: insights from plant–herbivore–predator interactions Open
Microbes play a critical role in regulating tri-trophic interactions among plants, herbivores, and their natural enemies, influencing key ecological and evolutionary processes. To fully understand these interactions through the food chain,…
View article: The ABC toxin complex from <i>Yersinia entomophaga</i> can package three different cytotoxic components expressed from distinct genetic loci in an unfolded state: the structures of both shell and cargo
The ABC toxin complex from <i>Yersinia entomophaga</i> can package three different cytotoxic components expressed from distinct genetic loci in an unfolded state: the structures of both shell and cargo Open
Bacterial ABC toxin complexes (Tcs) comprise three core proteins: TcA, TcB and TcC. The TcA protein forms a pentameric assembly that attaches to the surface of target cells and penetrates the cell membrane. The TcB and TcC proteins assembl…
View article: Stepwise assembly and release of Tc toxins from Yersinia entomophaga
Stepwise assembly and release of Tc toxins from Yersinia entomophaga Open
Tc toxins are virulence factors of bacterial pathogens. Although their structure and intoxication mechanism are well understood, it remains elusive where this large macromolecular complex is assembled and how it is released. Here we show b…
View article: <i>Serratia</i>‐based toxin cluster elements are associated with a type I fimbria
<i>Serratia</i>‐based toxin cluster elements are associated with a type I fimbria Open
A soil bacterium in the Serratia genus, carrying a 153 kb conjugative amber disease‐associated plasmid (pADAP), is commercially exploited for population control of the New Zealand endemic pest beetle Costelytra giveni (Coleoptera: Scarabae…
View article: <i>Serratia</i> spp. bacteria evolved in Aotearoa-New Zealand for infection of endemic scarab beetles
<i>Serratia</i> spp. bacteria evolved in Aotearoa-New Zealand for infection of endemic scarab beetles Open
The Melolonthinae branch of the beetle family Scarabaeidae has evolved in isolation in Aotearoa, radiating into >100 endemic species, since Aotearoa separated from Gondwanaland 82 million years ago. The group includes important pasture pes…
View article: THE INTERSECTION OF MICROBIAL FERMENTATION AND EVOLUTIONARY ECOLOGY
THE INTERSECTION OF MICROBIAL FERMENTATION AND EVOLUTIONARY ECOLOGY Open
Evolution can be perceived as resulting from a sequence of competitive events during which biological groups attempt to establish their control over increasingly greater amounts of territory and ecosystem functions. Those functions which m…
View article: INDEX
INDEX Open
Alfalfa Medicago sativa with guinea grass Megathyrsus maximus, whole plants, 52 Alkalihalobacillus alcalophilus, 70 Alkalihalobacillus clausii, 51 Alphaflexiviridae, 80 α-acids in beer, Humulone, 233, 247 α-Amylase inhibitor, 96 α-Amylase …
View article: Lysis Cassette-Mediated Exoprotein Release in Yersinia entomophaga Is Controlled by a PhoB-Like Regulator
Lysis Cassette-Mediated Exoprotein Release in Yersinia entomophaga Is Controlled by a PhoB-Like Regulator Open
While theoretical models exist, there is not yet any empirical data that links ALC phage-like lysis cassettes with the release of large macro-molecular toxin complexes, such as Yen-Tc in Gram-negative bacteria. In this study, we demonstrat…
View article: Lysis cassette-mediated exoprotein release in<i>Yersinia entomophaga</i>is controlled by a PhoB- like regulator
Lysis cassette-mediated exoprotein release in<i>Yersinia entomophaga</i>is controlled by a PhoB- like regulator Open
Secretion of exoproteins is a key component of bacterial virulence and is tightly regulated in response to environmental stimuli and host-dependent signals. The entomopathogenic bacterium Yersinia entomophaga MH96 produces a wide range of …
View article: Purification of High-Molecular-Weight Antibacterial Proteins of Insect Pathogenic Brevibacillus laterosporus Isolates
Purification of High-Molecular-Weight Antibacterial Proteins of Insect Pathogenic Brevibacillus laterosporus Isolates Open
Brevibacillus laterosporus (Bl) is a Gram-positive and spore-forming bacterium belonging to the Brevibacillus brevis phylogenetic cluster. Globally, insect pathogenic strains of the bacterium have been isolated, characterised, and some act…
View article: Purification of High Molecular-Weight Antibacterial Proteins of Insect Pathogenic <em>Brevibacillus Laterosporus</em> Isolates
Purification of High Molecular-Weight Antibacterial Proteins of Insect Pathogenic <em>Brevibacillus Laterosporus</em> Isolates Open
Brevibacillus laterosporus (Bl) is a Gram-positive and spore-forming bacterium belonging to the Brevibacillus brevis phylogenetic cluster. Globally, insect pathogenic strains of the bacterium have been isolated, characterised, and some act…
View article: Isolation, Purification, and Characterisation of a Phage Tail-Like Bacteriocin from the Insect Pathogenic Bacterium Brevibacillus laterosporus
Isolation, Purification, and Characterisation of a Phage Tail-Like Bacteriocin from the Insect Pathogenic Bacterium Brevibacillus laterosporus Open
The Gram-positive and spore-forming bacterium Brevibacillus laterosporus (Bl) belongs to the Brevibacillus brevis phylogenetic cluster. Isolates of the species have demonstrated pesticidal potency against a wide range of invertebrate pests…
View article: Genome sequence of the entomopathogenic Serratia entomophila isolate 626 and characterisation of the species specific itaconate degradation pathway
Genome sequence of the entomopathogenic Serratia entomophila isolate 626 and characterisation of the species specific itaconate degradation pathway Open
Background : Isolates of Serratia entomophila and S. proteamaculans (Yersiniaceae) cause disease specific to the endemic New Zealand pasture pest, Costelytra giveni (Coleoptera: Scarabaeidae). Previous genomic profiling has shown that S. e…
View article: Isolation, purification, and characterisation of a phage tail-like bacteriocin from the insect pathogenic bacterium <i>Brevibacillus laterosporus</i>
Isolation, purification, and characterisation of a phage tail-like bacteriocin from the insect pathogenic bacterium <i>Brevibacillus laterosporus</i> Open
The gram-positive and spore-forming bacterium Brevibacillus laterosporus ( Bl ) belongs to the Brevibacillus brevis phylogenetic cluster. Isolates of the species have demonstrated pesticidal potency against a wide range of invertebrate pes…
View article: Identification of genes involved in exoprotein release using a high-throughput exoproteome screening assay in Yersinia entomophaga
Identification of genes involved in exoprotein release using a high-throughput exoproteome screening assay in Yersinia entomophaga Open
Bacterial protein secretion is crucial to the maintenance of viability and pathogenicity. Although many bacterial secretion systems have been identified, the underlying mechanisms regulating their expression are less well explored. Yersini…
View article: Additional file 1 of Genome sequence of the entomopathogenic Serratia entomophila isolate 626 and characterisation of the species specific itaconate degradation pathway
Additional file 1 of Genome sequence of the entomopathogenic Serratia entomophila isolate 626 and characterisation of the species specific itaconate degradation pathway Open
Additional file 1. COG breakdown of Serratia entomophila 626 in comparison to the 5 selected Serratia species from Genbank. No. denotes number of COGs per isolate; % the percentage of the genome made up by this category.
View article: Identification of Diverse Toxin Complex Clusters and an eCIS Variant in Serratia proteamaculans Pathovars of the New Zealand Grass Grub ( <i>Costelytra Giveni</i> ) and Manuka Beetle ( <i>Pyronota</i> Spp.) Larvae
Identification of Diverse Toxin Complex Clusters and an eCIS Variant in Serratia proteamaculans Pathovars of the New Zealand Grass Grub ( <i>Costelytra Giveni</i> ) and Manuka Beetle ( <i>Pyronota</i> Spp.) Larvae Open
New pathotypes of the insect pathogen Serratia , each with differing virulence attributes and host specificity toward larvae of the New Zealand manuka beetle and grass grub, have been identified. All of the Serratia proteamaculans isolates…
View article: Structure, function and evolution of the orally active insecticidal toxin complex, YenTc
Structure, function and evolution of the orally active insecticidal toxin complex, YenTc Open
Yersinia entomophaga is a naturally occurring, Gram negative insect pathogen, first isolated from the diseased larvae of the New Zealand grass grub C. zealandica a decade ago [1].Its main virulence determinant is YenTc, a heterogenous 2.4 …
View article: Investigating the Process of Sheath Maturation in Antifeeding Prophage: a Phage Tail-Like Protein Translocation Structure
Investigating the Process of Sheath Maturation in Antifeeding Prophage: a Phage Tail-Like Protein Translocation Structure Open
Members of the contractile bacteriophage-related but evolutionarily divergent eCIS contain not one but three sheath proteins, two of which, namely, Afp2 and Afp3 in the Afp, arranged as alternate hexameric stacks constitute the helical she…
View article: Characterization of a new strain of<i>Metarhizium novozealandicum</i>with potential to be developed as a biopesticide
Characterization of a new strain of<i>Metarhizium novozealandicum</i>with potential to be developed as a biopesticide Open
The fungal species Metarhizium novozealandicum, that occurs only in New Zealand and Australia has been poorly studied. In this work, a new strain of M. novozealandicum isolated from a larva of Wiseana sp. is described based on morphology, …
View article: <i>In vivo</i> transcriptome analysis provides insights into host-dependent expression of virulence factors by <i>Yersinia entomophaga</i> MH96, during infection of <i>Galleria mellonella</i>
<i>In vivo</i> transcriptome analysis provides insights into host-dependent expression of virulence factors by <i>Yersinia entomophaga</i> MH96, during infection of <i>Galleria mellonella</i> Open
The function of microbes can be inferred from knowledge of genes specifically expressed in natural environments. Here, we report the in vivo transcriptome of the entomopathogenic bacterium Yersinia entomophaga MH96, captured during initial…
View article: <i>In vivo</i>transcriptome analysis provides insights into host-dependent expression of virulence factors by<i>Yersinia entomophaga</i>MH96, during infection of<i>Galleria mellonella</i>
<i>In vivo</i>transcriptome analysis provides insights into host-dependent expression of virulence factors by<i>Yersinia entomophaga</i>MH96, during infection of<i>Galleria mellonella</i> Open
The function of microbes can be inferred from knowledge of genes specifically expressed in natural environments. Here we report the in vivo transcriptome of the entomopathogenic bacterium Yersinia entomophaga MH96, captured during three st…