Mark R. Johnson
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View article: The Quantum Brain: The Untold Story of Docosahexaenoic Acid’s Role in Brain Evolution, Biophysics, and Cognition
The Quantum Brain: The Untold Story of Docosahexaenoic Acid’s Role in Brain Evolution, Biophysics, and Cognition Open
Docosahexaenoic acid (DHA), the dominant polyunsaturated fatty acid in photoreceptors, neurons, and synapses, is usually described as a passive structural membrane constituent. We propose a different view: DHA is a quantum-electronically a…
View article: Gestational Diabetes Exposed Mesenchymal Stem Cells: Phenotypic Differences Link to Long-Term Health of Offspring
Gestational Diabetes Exposed Mesenchymal Stem Cells: Phenotypic Differences Link to Long-Term Health of Offspring Open
Mesenchymal stem cells (MSCs) derived from the placenta, fetal membranes, or umbilical cord may be used to study the pathophysiology of gestational diabetes mellitus (GDM). The phenotype of MSCs may reflect fetal programming in response to…
View article: Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III
Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III Open
Aims Data on cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome are limited. We examine the cardiovascular and pregnancy outcomes in these women and analyse aortic growth throughout pregnancy. Methods and resu…
View article: Connective tissue disorder and high risk pregnancy: a case series with personalised external aortic root support (PEARS)
Connective tissue disorder and high risk pregnancy: a case series with personalised external aortic root support (PEARS) Open
Aortopathy including Marfan (MFS) and Loeys-Dietz syndrome (LDS) poses a high risk of aortic dissection, particularly during pregnancy and the puerperium. Current preventive measures of aortic root dilatation include medical therapy and pr…
View article: Pregnancy outcomes in women with heritable thoracic aortic disease: data from the EORP ESC registry of pregnancy and cardiac disease (ROPAC) III
Pregnancy outcomes in women with heritable thoracic aortic disease: data from the EORP ESC registry of pregnancy and cardiac disease (ROPAC) III Open
Aims The risk of pregnancy in women with heritable thoracic aortic disease (HTAD) is estimated to be high, but supporting data are scarce. The aim of this study is to prospectively investigate pregnancy outcomes to improve patient manageme…
View article: Valve replacement during pregnancy: literature review including new data from the Registry Of Pregnancy And Cardiac disease III
Valve replacement during pregnancy: literature review including new data from the Registry Of Pregnancy And Cardiac disease III Open
OBJECTIVES Heart valve replacement during pregnancy is sometimes unavoidable, and the need for anticoagulation further complicates these procedures. Our study describes cases of valve replacement in pregnancy enrolled in the Registry Of Pr…
View article: A randomised feasibility tolerability study of aminophylline for the prevention of preterm labour
A randomised feasibility tolerability study of aminophylline for the prevention of preterm labour Open
Background Progesterone is known to maintain uterine quiescence as pregnancy advances. Recently, its efficacy in preventing preterm birth has been questioned prompting a search for an alternative treatment option. Cyclic AMP has been shown…
View article: Maternal cytokine and cellular adhesion molecules profile in pregnant women with and without congenital heart disease.
Maternal cytokine and cellular adhesion molecules profile in pregnant women with and without congenital heart disease. Open
There was minimal fluctuation in the levels of the studies cytokines during pregnancy with exception of GROα and ghrelin, both implicated in fetal growth. Women with CHD had higher levels of proinflammatory cytokines and ICAM in the first …
View article: Relationships of maternal hemodynamics in the third trimester with fetal umbilical artery doppler indices, estimated fetal weight and birth weight in women with and without congenital heart disease
Relationships of maternal hemodynamics in the third trimester with fetal umbilical artery doppler indices, estimated fetal weight and birth weight in women with and without congenital heart disease Open
Objective To compare differences in maternal hemodynamics, measured non‐invasively by impedance cardiography and mean arterial blood pressure (MAP)—at rest and with high‐intensity exercise—between pregnant women with corrected congenital h…
View article: Depression and anxiety in the pregnant Omani population in relation to their fatty acid intake and levels
Depression and anxiety in the pregnant Omani population in relation to their fatty acid intake and levels Open
Maternal omega-3 FAs exert a favourable effect on vital perinatal health outcomes. Fish and seafood intake or omega-3 FAs supplementation are highly recommended for women during pregnancy to ensure the well-being of both the mother and fet…
View article: Dynamic roles of ILC3 in endometrial repair and regeneration
Dynamic roles of ILC3 in endometrial repair and regeneration Open
Background Innate lymphoid cells (ILCs) are prominent in the human uterine mucosa and play physiological roles in pregnancy. ILC3 are the second-most common ILC subset in the uterine mucosa, but their role remains unclear. Methods Here we …
View article: Perinatal outcomes after selective third‐trimester ultrasound screening for small‐for‐gestational age: prospective cohort study nested within <scp>DESiGN</scp> randomized controlled trial
Perinatal outcomes after selective third‐trimester ultrasound screening for small‐for‐gestational age: prospective cohort study nested within <span>DESiGN</span> randomized controlled trial Open
Objective In screening for small‐for‐gestational age ( SGA ) using third‐trimester antenatal ultrasound, there are concerns about the low detection rates and potential for harm caused by both false‐negative and false‐positive screening res…
View article: Differences in Factors Associated With Preterm and Term Stillbirth: A Secondary Cohort Analysis of the <scp>DESiGN</scp> Trial
Differences in Factors Associated With Preterm and Term Stillbirth: A Secondary Cohort Analysis of the <span>DESiGN</span> Trial Open
Objective To identify whether maternal and pregnancy characteristics associated with stillbirth differ between preterm and term stillbirth. Design Secondary cohort analysis of the DESiGN RCT. Setting Thirteen UK maternity units. Population…
View article: Dynamic roles of ILC3 in endometrial repair and regeneration
Dynamic roles of ILC3 in endometrial repair and regeneration Open
Innate lymphoid cells (ILC) are prominent in the human uterine mucosa and play physiological roles in pregnancy. ILC3 are the second-most common ILC subset in the uterine mucosa, but their role remains unclear. Here we define two subsets o…
View article: ACE Inhibitor and Angiotensin Receptor Blocker Use During Pregnancy: Data From the ESC Registry Of Pregnancy and Cardiac Disease (ROPAC)
ACE Inhibitor and Angiotensin Receptor Blocker Use During Pregnancy: Data From the ESC Registry Of Pregnancy and Cardiac Disease (ROPAC) Open
Angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) are not recommended during the second and third trimester because of the significant risk of congenital anomalies associated with their use. However…
View article: Diuretics in pregnancy: Data from the ESC Registry of Pregnancy and Cardiac disease (ROPAC)
Diuretics in pregnancy: Data from the ESC Registry of Pregnancy and Cardiac disease (ROPAC) Open
Aims Data on diuretic use in pregnancy are limited and inconsistent, and consequently it remains unclear whether they can be used safely. Our study aims to evaluate the perinatal outcomes after in‐utero diuretic exposure. Methods and resul…
View article: Maternal cardiovascular adaptation to pregnancy in obese pregnant women
Maternal cardiovascular adaptation to pregnancy in obese pregnant women Open
Introduction Obesity is known to be associated with cardiovascular compromise and a major risk factor for the development of hypertensive disorders in pregnancy. However, little is known about the effect of obesity on maternal cardiac func…
View article: Multigenerational diabetes mellitus
Multigenerational diabetes mellitus Open
Gestational diabetes (GDM) changes the maternal metabolic and uterine environment, thus increasing the risk of short- and long-term adverse outcomes for both mother and child. Children of mothers who have GDM during their pregnancy are mor…
View article: The safety, acceptability, and success rates of amniocentesis in the context of preterm prelabor rupture of membranes and threatened preterm labor: a systematic review and meta-analysis
The safety, acceptability, and success rates of amniocentesis in the context of preterm prelabor rupture of membranes and threatened preterm labor: a systematic review and meta-analysis Open
This systematic review found that amniocentesis in cases of PPROM or threatened preterm labor is a safe and feasible procedure. These data should give care providers confidence to counsel patients appropriately.