Mark R. Waddle
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View article: Personalizing prostate cancer education for patients using an EHR-Integrated LLM agent
Personalizing prostate cancer education for patients using an EHR-Integrated LLM agent Open
Cancer patients often lack timely education and personalized support due to clinician workload. This quality improvement study develops and evaluates a Large Language Model (LLM) agent, MedEduChat, which is integrated with the clinic’s ele…
View article: RADONC-GPT: AN AUTONOMOUS SYSTEM FOR DATA-DRIVEN RADIATION ONCOLOGY TASKS
RADONC-GPT: AN AUTONOMOUS SYSTEM FOR DATA-DRIVEN RADIATION ONCOLOGY TASKS Open
View article: A Randomized, Parallel Phase II Trial of Hypofractionated Proton Therapy or IMRT for Recurrent, Oligometastatic Prostate Cancer with Pelvic and/or Para-aortic Lymph Node Involvement Following Primary Localized Treatment with Radiotherapy
A Randomized, Parallel Phase II Trial of Hypofractionated Proton Therapy or IMRT for Recurrent, Oligometastatic Prostate Cancer with Pelvic and/or Para-aortic Lymph Node Involvement Following Primary Localized Treatment with Radiotherapy Open
View article: Immediate 2-Stage breast reconstruction outcomes after proton or photon postmastectomy radiotherapy
Immediate 2-Stage breast reconstruction outcomes after proton or photon postmastectomy radiotherapy Open
View article: Cost-Effectiveness Analysis of Mepitel Film for Prevention of Acute Radiation Dermatitis in Breast Cancer: a Canadian Healthcare Perspective
Cost-Effectiveness Analysis of Mepitel Film for Prevention of Acute Radiation Dermatitis in Breast Cancer: a Canadian Healthcare Perspective Open
Introduction While randomized clinical trials (RCT) confirmed superiority of Mepitel film (MF) in reducing acute radiation dermatitis (ARD) compared to standard-of-care (SoC), the incremental cost difference has limited its use. A cost-eff…
View article: 218 Retrospective comparative analysis of prostate cancer in-basket messages: Responses from closed-domain LLM vs. clinical teams
218 Retrospective comparative analysis of prostate cancer in-basket messages: Responses from closed-domain LLM vs. clinical teams Open
Objectives/Goals: Our study’s objective is to evaluate RadOnc-GPT, a GPT-4o powered LLM, in generating responses to in-basket messages related to prostate cancer treatment in the Radiation Oncology department. By integrating it with electr…
View article: Factors Associated with Advanced Presentations of Melanoma in the United States from 2004-2015: A National Cancer Database Analysis Cohort Study
Factors Associated with Advanced Presentations of Melanoma in the United States from 2004-2015: A National Cancer Database Analysis Cohort Study Open
Purpose: Significant advances have been made in the diagnosis and treatment of melanoma, but mortality remains high. The primary aim of this study was to identify risk factors associated with advanced presentations of melanoma in the US. M…
View article: Longitudinal assessment of quality-of-life in prostate cancer patients treated with intensity-modulated proton therapy targeting the prostate and pelvic lymph nodes
Longitudinal assessment of quality-of-life in prostate cancer patients treated with intensity-modulated proton therapy targeting the prostate and pelvic lymph nodes Open
View article: Retrospective Comparative Analysis of Prostate Cancer In-Basket Messages: Responses From Closed-Domain Large Language Models Versus Clinical Teams
Retrospective Comparative Analysis of Prostate Cancer In-Basket Messages: Responses From Closed-Domain Large Language Models Versus Clinical Teams Open
RadOnc-GPT has the potential to considerably reduce the workload of clinical care teams by generating high-quality, timely responses for in-basket message interactions. This could lead to improved efficiency in health care workflows and re…
View article: Personalizing Prostate Cancer Education for Patients Using an EHR-Integrated LLM Agent
Personalizing Prostate Cancer Education for Patients Using an EHR-Integrated LLM Agent Open
Cancer patients often lack timely education and personalized support due to clinician workload. This quality improvement study develops and evaluates a Large Language Model (LLM) agent, MedEduChat, which is integrated with the clinic's ele…
View article: Retrospective Comparative Analysis of Prostate Cancer In-Basket Messages: Responses from Closed-Domain LLM vs. Clinical Teams
Retrospective Comparative Analysis of Prostate Cancer In-Basket Messages: Responses from Closed-Domain LLM vs. Clinical Teams Open
In-basket message interactions play a crucial role in physician-patient communication, occurring during all phases (pre-, during, and post) of a patient's care journey. However, responding to these patients' inquiries has become a signific…
View article: Dosimetric Features of Ultra-Hypofractionated Intensity Modulated Proton Therapy for Prostate Cancer
Dosimetric Features of Ultra-Hypofractionated Intensity Modulated Proton Therapy for Prostate Cancer Open
View article: Accuracy of a Cancer Registry Versus Clinical Care Team Chart Abstraction in Identifying Cancer Recurrence
Accuracy of a Cancer Registry Versus Clinical Care Team Chart Abstraction in Identifying Cancer Recurrence Open
Currently, institutional cancer registry recurrence data lacks the required accuracy for implementation into studies without manual confirmation. Longer follow-up of cancer status will likely improve sensitivity. No identified differences …
View article: Integration of Telemedicine Consultation Into a Tertiary Radiation Oncology Department: Predictors of Use, Treatment Yield, and Effects on Patient Population
Integration of Telemedicine Consultation Into a Tertiary Radiation Oncology Department: Predictors of Use, Treatment Yield, and Effects on Patient Population Open
PURPOSE The COVID-19 pandemic led to rapid expansion of telemedicine. The implications of telemedicine have not been rigorously studied in radiation oncology, a procedural specialty. This study aimed to evaluate the characteristics of in-p…
View article: Search in Free-Text Radiology Report Database Using Large Language Model Cooperation
Search in Free-Text Radiology Report Database Using Large Language Model Cooperation Open
View article: Retrospective Comparative Analysis of Prostate Cancer In-Basket Messages: Responses from Closed-Domain LLM vs. Clinical Teams
Retrospective Comparative Analysis of Prostate Cancer In-Basket Messages: Responses from Closed-Domain LLM vs. Clinical Teams Open
View article: Proton versus photon craniospinal irradiation for adult medulloblastoma: A dosimetric, toxicity, and exploratory cost analysis
Proton versus photon craniospinal irradiation for adult medulloblastoma: A dosimetric, toxicity, and exploratory cost analysis Open
Background This study aimed to determine whether proton craniospinal irradiation (CSI) decreased the dose to normal tissue and resulted in less toxicity than photon CSI for adult patients. Methods This single-institution retrospective anal…
View article: Non-Operative Management of Rectal or Anal Canal Adenocarcinoma: National Cancer Database Analysis of the Impact of Disease, Treatment, and Social Determinants of Health on Overall Survival
Non-Operative Management of Rectal or Anal Canal Adenocarcinoma: National Cancer Database Analysis of the Impact of Disease, Treatment, and Social Determinants of Health on Overall Survival Open
View article: Improving the Radiation Oncology Alternative Payment Model
Improving the Radiation Oncology Alternative Payment Model Open
View article: Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT
Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT Open
Prostate cancer patients undergoing external beam radiation therapy (EBRT) benefit from a full bladder to decrease bowel and bladder toxicity. Ultrasound may offer a proxy metric for evaluation, sparing CBCT dosing. Patients were prospecti…
View article: Comparing Oncologic Outcomes and Toxicity for Combined Modality Therapy vs. Carbon-Ion Radiotherapy for Previously Irradiated Locally Recurrent Rectal Cancer
Comparing Oncologic Outcomes and Toxicity for Combined Modality Therapy vs. Carbon-Ion Radiotherapy for Previously Irradiated Locally Recurrent Rectal Cancer Open
No standard treatment paradigm exists for previously irradiated locally recurrent rectal cancer (PILRRC). Carbon-ion radiotherapy (CIRT) may improve oncologic outcomes and reduce toxicity compared with combined modality therapy (CMT). Eigh…
View article: Postmastectomy Intensity Modulated Proton Therapy: 5-Year Oncologic and Patient-Reported Outcomes
Postmastectomy Intensity Modulated Proton Therapy: 5-Year Oncologic and Patient-Reported Outcomes Open
View article: Single and Multifraction Spine Stereotactic Body Radiation Therapy and the Risk of Radiation Induced Myelopathy
Single and Multifraction Spine Stereotactic Body Radiation Therapy and the Risk of Radiation Induced Myelopathy Open
View article: Dosimetric Analysis of Axillary Lymph Node Coverage Using High Tangents in the Prone Position for Left-Sided Breast Cancers
Dosimetric Analysis of Axillary Lymph Node Coverage Using High Tangents in the Prone Position for Left-Sided Breast Cancers Open
Treating patients in the prone position with high tangents provides excellent coverage of axillary levels I and II, although there is minimal coverage of axillary level III. Prospective trials are needed to evaluate the clinical outcomes w…
View article: Development and Assessment of a Predictive Score for Vertebral Compression Fracture After Stereotactic Body Radiation Therapy for Spinal Metastases
Development and Assessment of a Predictive Score for Vertebral Compression Fracture After Stereotactic Body Radiation Therapy for Spinal Metastases Open
The results of this cohort study identify a subgroup of patients with high risk for VCF following treatment with SBRT who may potentially benefit from undergoing prophylactic spinal stabilization or vertebroplasty.
View article: Estimated Cost of Circulating Tumor DNA for Posttreatment Surveillance of Human Papillomavirus–Associated Oropharyngeal Cancer
Estimated Cost of Circulating Tumor DNA for Posttreatment Surveillance of Human Papillomavirus–Associated Oropharyngeal Cancer Open
This cross-sectional study compares the cost and effectiveness of 3 posttreatment strategies for surveillance of human papillomavirus (HPV)–associated oropharyngeal cancer.
View article: RADT-10. DEVELOPMENT AND INTERNAL VALIDATION OF A PREDICTIVE SCORE FOR VERTEBRAL COMPRESSION FRACTURE AFTER STEREOTACTIC BODY RADIATION THERAPY FOR SPINAL METASTASES
RADT-10. DEVELOPMENT AND INTERNAL VALIDATION OF A PREDICTIVE SCORE FOR VERTEBRAL COMPRESSION FRACTURE AFTER STEREOTACTIC BODY RADIATION THERAPY FOR SPINAL METASTASES Open
PURPOSE Vertebral compression fracture (VCF) is a potential adverse effect following stereotactic body radiation therapy (SBRT) for spinal metastases. In this analysis, we developed and internally validated a risk stratification model for …
View article: RADT-26. PROTON VERSUS PHOTON CRANIOSPINAL IRRADIATION FOR ADULT MEDULLOBLASTOMA: A DOSIMETRIC AND TOXICITY ANALYSIS
RADT-26. PROTON VERSUS PHOTON CRANIOSPINAL IRRADIATION FOR ADULT MEDULLOBLASTOMA: A DOSIMETRIC AND TOXICITY ANALYSIS Open
Medulloblastoma is a posterior fossa tumor rarely diagnosed in adults. Treatment includes craniospinal irradiation (CSI). Proton CSI is increasingly utilized to decrease radiation dose to normal tissues, despite the lack of randomized data…
View article: Cost-Effectiveness of Treatment Strategies for High-Risk Prostate Cancer
Cost-Effectiveness of Treatment Strategies for High-Risk Prostate Cancer Open
View article: Boron Neutron Capture Therapy: A Review of Clinical Applications
Boron Neutron Capture Therapy: A Review of Clinical Applications Open
Boron neutron capture therapy (BNCT) is an emerging treatment modality aimed at improving the therapeutic ratio for traditionally difficult to treat tumors. BNCT utilizes boronated agents to preferentially deliver boron-10 to tumors, which…