Mark Guttman
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View article: Trauma surgical educational opportunities in Canada: a week in the life of a trauma service
Trauma surgical educational opportunities in Canada: a week in the life of a trauma service Open
Trauma educational opportunities remain heterogeneous across Canada. Higher volumes of patients with trauma were seen during the summer. Penetrating mechanism and TTAs with a trauma surgeon present appear to increase opportunities to perfo…
View article: Atypical Presentations of Huntington Disease‐like 2 in South African Individuals
Atypical Presentations of Huntington Disease‐like 2 in South African Individuals Open
Background Huntington disease‐like 2 (HDL2) is a neurodegenerative disorder, affecting only individuals of African ancestry. Full penetrance occurs in individuals with 40 repeats or more. Objective To describe the phenotypic variability of…
View article: Safety and feasibility of research lumbar puncture in Huntington’s disease: the HDClarity cohort and bioresource
Safety and feasibility of research lumbar puncture in Huntington’s disease: the HDClarity cohort and bioresource Open
STRUCTURED ABSTRACT Background Biomarkers are needed to monitor disease progression, target engagement and efficacy in Huntington’s disease (HD). Cerebrospinal fluid (CSF) is an ideal medium to research such biomarkers due to its proximity…
View article: The Impact of Upcoming Treatments in Huntington’s Disease: Resource Capacity Limitations and Access to Care Implications
The Impact of Upcoming Treatments in Huntington’s Disease: Resource Capacity Limitations and Access to Care Implications Open
Background: The most advanced disease-modifying therapies (DMTs) in development for Huntington’s disease (HD) require intrathecal (IT) administration, which may create or exacerbate bottlenecks in resource capacity. Objective: To understan…
View article: Recommendations for the Organization of Multidisciplinary Clinical Care Teams in Parkinson’s Disease
Recommendations for the Organization of Multidisciplinary Clinical Care Teams in Parkinson’s Disease Open
We provide a practical tool to improve multidisciplinary care for persons with PD at the organizational level. Future studies should focus on implementing these recommendations in clinical practice, evaluating their potential applicability…
View article: Locus of control in patients with Huntington disease: a cross-sectional study.
Locus of control in patients with Huntington disease: a cross-sectional study. Open
As patients with chronic pain and neurodegenerative diseases such as HD are likely to present for chiropractic care, identifying factors such as anxiety, depression and LOC may affect patients' response to care.
View article: Telemedicine for Hyperkinetic Movement Disorders
Telemedicine for Hyperkinetic Movement Disorders Open
Telemedicine is the use of electronic communication technology to facilitate healthcare between distant providers and patients. In addition to synchronous video
\nconferencing, asynchronous video transfer has been used to support care for …
View article: Telemedicine for Hyperkinetic Movement Disorders
Telemedicine for Hyperkinetic Movement Disorders Open
Telemedicine is the use of electronic communication technology to facilitate healthcare between distant providers and patients. In addition to synchronous video conferencing, asynchronous video transfer has been used to support care for ne…
View article: Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies
Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies Open
Positron emission tomography (PET) imaging of the translocator protein (TSPO) is widely used as a biomarker of microglial activation. However, TSPO protein concentration in human brain has not been optimally quantified nor has its regional…
View article: Inspiratory Myoclonus
Inspiratory Myoclonus Open
Background: Movement disorders of respiration are rare and are restricted to a phase of the respiratory cycle. Phenomenology Shown: The intermittent inspiratory myoclonus in this patient with post-anoxic encephalopathy is likely to be of b…
View article: Inspiratory Myoclonus
Inspiratory Myoclonus Open
Background: Movement disorders of respiration are rare and are restricted to a phase of the respiratory cycle. Phenomenology Shown: The intermittent inspiratory myoclonus in this patient with post-anoxic encephalopathy is likely to be of b…
View article: What predicts falls in Parkinson disease?
What predicts falls in Parkinson disease? Open
This large-scale analysis identified several predictors of progression to falling in PD. Such identifiers may help target patient subgroups for falls prevention intervention. Some factors are modifiable, offering opportunities for developi…
View article: Telemedicine Enables Broader Access to Movement Disorders Curricula for Medical Students
Telemedicine Enables Broader Access to Movement Disorders Curricula for Medical Students Open
Background: The impact of tele-education for movement disorders on medical students is unknown. The present study had three objectives. First, to create a tele-education program for medical students in regions with limited access to moveme…
View article: Telemedicine Enables Broader Access to Movement Disorders Curricula for Medical Students
Telemedicine Enables Broader Access to Movement Disorders Curricula for Medical Students Open
Background: The impact of tele-education for movement disorders on medical students is unknown. The present study had three objectives. First, to create a tele-education program for medical students in regions with limited access to moveme…
View article: Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders
Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders Open
See Jellinger (doi:10.1093/awx190) for a scientific commentary on this article. The enzyme monoamine oxidases (B and A subtypes, encoded by MAOB and MAOA, respectively) are drug targets in the treatment of Parkinson’s disease. Inhibitors o…
View article: A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease
A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease Open
This article provides Class I evidence that CoQ does not slow the progressive functional decline of patients with HD.
View article: Regular Exercise, Quality of Life, and Mobility in Parkinson’s Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data
Regular Exercise, Quality of Life, and Mobility in Parkinson’s Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data Open
Background: Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson’s disease (PD). Objective: To examine whether exercise habits were associated with changes in HRQL and mo…
View article: Health Care Delivery Practices in Huntington’s Disease Specialty Clinics: An International Survey
Health Care Delivery Practices in Huntington’s Disease Specialty Clinics: An International Survey Open
Most centers serve a large population and use a multidisciplinary approach. The survey gives insight into factors underpinning HD service delivery globally. There is a need for more in-depth studies of clinical practice to understand how s…
View article: Longitudinal Changes in the Motor Learning-Related Brain Activation Response in Presymptomatic Huntington's Disease
Longitudinal Changes in the Motor Learning-Related Brain Activation Response in Presymptomatic Huntington's Disease Open
Neurocognitive decline, including deficits in motor learning, occurs in the presymptomatic phase of Huntington's disease (HD) and precedes the onset of motor symptoms. Findings from recent neuroimaging studies have linked these deficits to…
View article: D <sub>3</sub> dopamine receptor-preferring [ <sup>11</sup> C]PHNO PET imaging in Parkinson patients with dyskinesia
D <sub>3</sub> dopamine receptor-preferring [ <sup>11</sup> C]PHNO PET imaging in Parkinson patients with dyskinesia Open
Dopaminergic abnormalities contributing to LID may include elevated D2/3 binding in globus pallidus, perhaps reflecting D3 receptor upregulation. The findings support therapeutic strategies that target and diminish activity at D3 to preven…
View article: Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS)
Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS) Open
Using these prospectively accrued clinical data, relatively large treatment effects would be required to mount a randomized, placebo-controlled clinical trial involving premanifest HD individuals who carry the CAG expansion.