Mark Rodgers
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View article: GEODE: an in silico tool that translates in vitro to in vivo predictions of tuberculosis antibiotic combination efficacy
GEODE: an in silico tool that translates in vitro to in vivo predictions of tuberculosis antibiotic combination efficacy Open
Introduction Tuberculosis (TB) remains the primary cause of death due to infectious disease in the world. TB, while treatable, requires an extended course of multiple antibiotics, taking 6–9 months, and many antibiotic regimens have delete…
View article: Spatially-distinct programming of macrophage diversity within the granulomas of <i>Mycobacterium tuberculosis</i> infected nonhuman primates
Spatially-distinct programming of macrophage diversity within the granulomas of <i>Mycobacterium tuberculosis</i> infected nonhuman primates Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is defined by granulomas— immune aggregates that either contain or support bacterial replication. Macrophages, fundamental components of these lesions, are crucial to TB pathog…
View article: The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control Open
SUMMARY Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium tuberculosis (Mtb) infection and support bacterial persistence. We previously discovered that human TB…
View article: CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques
CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques Open
Tuberculosis (TB) is a major cause of morbidity and mortality worldwide despite widespread intradermal (ID) BCG vaccination in newborns. We previously demonstrated that changing the route and dose of BCG vaccination from 5ξ10 5 CFU ID to 5…
View article: Markov Field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques
Markov Field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques Open
Summary Analysis of multi-modal datasets can identify multi-scale interactions underlying biological systems, but can be beset by spurious connections due to indirect impacts propagating through an unmapped biological network. For example,…
View article: CD4<sup>+</sup>T cells are homeostatic regulators during<i>Mtb</i>reinfection
CD4<sup>+</sup>T cells are homeostatic regulators during<i>Mtb</i>reinfection Open
Immunological priming – either in the context of prior infection or vaccination – elicits protective responses against subsequent Mycobacterium tuberculosis ( Mtb ) infection. However, the changes that occur in the lung cellular milieu pos…
View article: A “suicide” BCG strain provides enhanced immunogenicity and robust protection against <i>Mycobacterium tuberculosis</i> in macaques
A “suicide” BCG strain provides enhanced immunogenicity and robust protection against <i>Mycobacterium tuberculosis</i> in macaques Open
Intravenous (IV) BCG delivery provides robust protection against Mycobacterium tuberculosis (Mtb) in macaques but poses safety challenges. Here, we constructed two BCG strains (BCG-TetON-DL and BCG-TetOFF-DL) in which tetracyclines regulat…
View article: Development of an Engineered<i>Mycobacterium tuberculosis</i>Strain for a Safe and Effective Tuberculosis Human Challenge Model
Development of an Engineered<i>Mycobacterium tuberculosis</i>Strain for a Safe and Effective Tuberculosis Human Challenge Model Open
Human challenge experiments could greatly accelerate the development of a tuberculosis (TB) vaccine. Human challenge for tuberculosis requires a strain that can both replicate in the host and be reliably cleared. To accomplish this, we des…
View article: Does intravenous vaccination with self-killing BCG lead to development of an immune response that protects against <i>Mycobacterium tuberculosis</i>?
Does intravenous vaccination with self-killing BCG lead to development of an immune response that protects against <i>Mycobacterium tuberculosis</i>? Open
The use of intradermal BCG offers limited protection against tuberculosis. Intravenous (IV) administration of BCG has shown to produce robust protection against infection in a non-human primate model of tuberculosis. However, the duration …
View article: Characterizing the Spectrum of Latent<i>Mycobacterium tuberculosis</i>in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution
Characterizing the Spectrum of Latent<i>Mycobacterium tuberculosis</i>in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution Open
Mycobacterium tuberculosis infection outcomes have been described as active tuberculosis or latent infection but a spectrum of outcomes is now recognized. We used a nonhuman primate model, which recapitulates human infection, to characteri…
View article: Intensive behavioural interventions based on applied behaviour analysis (ABA) for young children with autism: A cost-effectiveness analysis
Intensive behavioural interventions based on applied behaviour analysis (ABA) for young children with autism: A cost-effectiveness analysis Open
Background The economic and social costs of autism are significant. This study evaluates the cost-effectiveness of early intensive Applied Behaviour Analysis (ABA)-based interventions for autistic pre-school children in the UK. Methods A d…
View article: Mental health promotion and protection relating to key life events and transitions in adulthood: a rapid systematic review of systematic reviews
Mental health promotion and protection relating to key life events and transitions in adulthood: a rapid systematic review of systematic reviews Open
Whilst evidence based mental health prevention and promotion is available during pregnancy and early parenthood and for bereavement, it is unclear how best to support adults experiencing job loss, unemployment, and housing problems.
View article: Mental health promotion and protection relating to key life events and transitions in adulthood: a rapid systematic review of systematic reviews
Mental health promotion and protection relating to key life events and transitions in adulthood: a rapid systematic review of systematic reviews Open
During the decades representing working-age adulthood, most people will experience one or several significant life events or transitions. These may present a challenge to mental health. The primary aim of this rapid systematic review of sy…
View article: A scoping review of systematic reviews on reducing lifestyle risk behaviours in disadvantaged groups
A scoping review of systematic reviews on reducing lifestyle risk behaviours in disadvantaged groups Open
Background Lifestyle risk behaviours are key risk factors for non-communicable diseases. Some disadvantaged groups face particularly poor health outcomes, which may be exacerbated by high prevalence of risk behaviours. The aim of this scop…
View article: P40 Is there an evidence base on reducing lifestyle risk behaviours in disadvantaged groups? A scoping review of systematic reviews
P40 Is there an evidence base on reducing lifestyle risk behaviours in disadvantaged groups? A scoping review of systematic reviews Open
Background Lifestyle risk behaviours are associated with an increased risk of non-communicable disease and mortality. There are socio-economic inequalities in these behaviours, with some behaviours being more prevalent in particular groups…
View article: Mental health among healthcare workers and other vulnerable groups during the COVID-19 pandemic and other coronavirus outbreaks: A rapid systematic review
Mental health among healthcare workers and other vulnerable groups during the COVID-19 pandemic and other coronavirus outbreaks: A rapid systematic review Open
Introduction Although most countries and healthcare systems worldwide have been affected by the COVID-19 pandemic, some groups of the population may be more vulnerable to detrimental effects of the pandemic on mental health than others. Th…
View article: Synthesis for health services and policy: case studies in the scoping of reviews
Synthesis for health services and policy: case studies in the scoping of reviews Open
Background For systematic reviews to be rigorous, deliverable and useful, they need a well-defined review question. Scoping for a review also requires the specification of clear inclusion criteria and planned synthesis methods. Guidance is…
View article: Intensive behavioural interventions based on applied behaviour analysis for young children with autism: An international collaborative individual participant data meta-analysis
Intensive behavioural interventions based on applied behaviour analysis for young children with autism: An international collaborative individual participant data meta-analysis Open
This individual participant data meta-analysis is the most intensive possible evaluation of the effectiveness of early intensive applied behaviour analysis–based interventions for pre-school autistic children compared with treatment as usu…
View article: Regulating and inspecting integrated health and social care in the UK: Scoping the literature
Regulating and inspecting integrated health and social care in the UK: Scoping the literature Open
Background: The integration of care, particularly across the health and social care sectors, has been a long-standing policy objective in the UK. We sought to scope the evidence related to the regulation and inspection of integrated care. …
View article: Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis
Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis Open
Background Early intensive applied behaviour analysis-based interventions are intensive interventions for autistic children that are often delivered on a one-to-one basis for 20–50 hours per week. Objectives To evaluate the clinical effect…
View article: Workplace-based interventions to promote healthy lifestyles in the NHS workforce: a rapid scoping and evidence map
Workplace-based interventions to promote healthy lifestyles in the NHS workforce: a rapid scoping and evidence map Open
Background The health and well-being of staff working in the NHS is a significant issue for UK health care. We sought to identify research relevant to the promotion of healthy lifestyles among NHS staff on behalf of NHS England. Objectives…
View article: MAIT cells are minimally responsive to Mycobacterium tuberculosis within granulomas, but are functionally impaired by SIV in a macaque model of SIV and Mtb co-infection
MAIT cells are minimally responsive to Mycobacterium tuberculosis within granulomas, but are functionally impaired by SIV in a macaque model of SIV and Mtb co-infection Open
Mucosal associated invariant T (MAIT) cells recognize and can directly destroy bacterially infected cells. While a role for MAIT cells has been suggested in several in vitro and in vivo models of M.tuberculosis (Mtb) infection, these studi…