Mark S. Cattral
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View article: Plasma Cell-free DNA Methylomes for Hepatocellular Carcinoma Detection and Monitoring After Liver Resection or Transplantation
Plasma Cell-free DNA Methylomes for Hepatocellular Carcinoma Detection and Monitoring After Liver Resection or Transplantation Open
Objective: To evaluate the utility of cfMeDIP-seq for detecting hepatocellular carcinoma (HCC) and monitoring recurrence following curative-intent liver surgery. Summary Background Data: HCC remains a leading cause of cancer mortality, wit…
View article: A confounder debiasing method for RCT-like comparability enables Machine Learning-based personalization of survival benefit in living donor liver transplantation
A confounder debiasing method for RCT-like comparability enables Machine Learning-based personalization of survival benefit in living donor liver transplantation Open
Many clinical questions in medicine cannot be answered through randomized controlled trials (RCTs) due to ethical or feasibility constraints. In such cases, observational data is often the only available resource for evaluating treatment e…
View article: Plasma cell-free DNA methylomes for hepatocellular carcinoma detection and monitoring after liver resection or transplantation
Plasma cell-free DNA methylomes for hepatocellular carcinoma detection and monitoring after liver resection or transplantation Open
Background Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide. HCC diagnosis, monitoring, and treatment decisions rely predominantly on imaging. Curative surgery is limited to those with disease conf…
View article: A305 ANONYMOUS LIVING LIVER DONATION IMPROVES ACCESS FOR MEDICALLY UNDERSERVED CHILDREN IN NEED OF LIVER TRANSPLANTATION
A305 ANONYMOUS LIVING LIVER DONATION IMPROVES ACCESS FOR MEDICALLY UNDERSERVED CHILDREN IN NEED OF LIVER TRANSPLANTATION Open
Background Since our first pediatric anonymous non-directed live donor liver transplant (A-LDLT) performed in April 2005, 62 children have undergone live donor liver transplant (LDLT) with an anonymous non-directed graft. Anon-LDLT organs …
View article: Should advanced donor age be a deterrent in the utilization of grafts from donation after cardiac death in deceased donor liver transplantation? The Toronto experience
Should advanced donor age be a deterrent in the utilization of grafts from donation after cardiac death in deceased donor liver transplantation? The Toronto experience Open
Donor age alone should not be the criterion to determine the acceptability of grafts in liver transplantation. With careful selection criteria, older DCD donors could make a valuable contribution to expanding the liver donor pool, with gra…
View article: Trajectories of patients relisted for liver transplantation
Trajectories of patients relisted for liver transplantation Open
Patients relisted for LT are carefully curated and comprise a minority of the waitlist population. Despite their younger age, they have worse liver/kidney function, poor waitlist survival, and decreased transplant incidence suggesting the …
View article: Availability of living donor optimizes timing of liver transplant in high-risk waitlisted cirrhosis patients
Availability of living donor optimizes timing of liver transplant in high-risk waitlisted cirrhosis patients Open
Liver transplant (LT) candidates have become older and frailer, with growing Non-alcoholic steatohepatitis (NASH) and comorbid disease burden in recent years, predisposing them for poor waitlist outcomes. We aimed to evaluate the impact of…
View article: Living donor liver transplantation can address disparities in transplant access for patients with primary sclerosing cholangitis
Living donor liver transplantation can address disparities in transplant access for patients with primary sclerosing cholangitis Open
Background: Liver transplantation (LT) is frequently lifesaving for people living with primary sclerosing cholangitis (PSC). However, patients are waitlisted for LT according to the model for end-stage liver disease-sodium (MELD-Na) score,…
View article: Impact of living donor liver transplantation on long‐term cardiometabolic and graft outcomes in cirrhosis due to nonalcoholic steatohepatitis
Impact of living donor liver transplantation on long‐term cardiometabolic and graft outcomes in cirrhosis due to nonalcoholic steatohepatitis Open
Overall, LDLT recipients had significantly better renal function by virtue of having early transplantation in their disease course. LDLT was also associated with significantly less graft cirrhosis, although OS and cardiometabolic outcomes …
View article: Data from <i>In Situ</i> Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model
Data from <i>In Situ</i> Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model Open
Purpose: How best to sequence and integrate immunotherapy into standard of care is currently unknown. Clinical protocols with accelerated nonablative hypofractionated radiation followed by surgery could provide an opportunity to implement …
View article: Figure S1 from <i>In Situ</i> Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model
Figure S1 from <i>In Situ</i> Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model Open
The AE17 and AB12 cell lines do not express PD-L1
View article: Figure S1 from <i>In Situ</i> Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model
Figure S1 from <i>In Situ</i> Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model Open
The AE17 and AB12 cell lines do not express PD-L1
View article: Data from <i>In Situ</i> Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model
Data from <i>In Situ</i> Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model Open
Purpose: How best to sequence and integrate immunotherapy into standard of care is currently unknown. Clinical protocols with accelerated nonablative hypofractionated radiation followed by surgery could provide an opportunity to implement …
View article: Long-term outcomes of ablation, liver resection, and liver transplant as first-line treatment for solitary HCC of 3 cm or less using an intention-to-treat analysis: A retrospective cohort study
Long-term outcomes of ablation, liver resection, and liver transplant as first-line treatment for solitary HCC of 3 cm or less using an intention-to-treat analysis: A retrospective cohort study Open
For treatment-naïve patients with solitary HCC ≤ 3 cm who are eligible for RFA, LR, and LT, adjusted ITT survival is equivalent amongst the treatment modalities, however, DFS is better with LR and LT, compared with RFA. Differences in recu…
View article: Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases
Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases Open
Importance Colorectal cancer is a leading cause of cancer-related death, and nearly 70% of patients with this cancer have unresectable colorectal cancer liver metastases (CRLMs). Compared with chemotherapy, liver transplant has been report…
View article: International Survey of Clinical Monitoring Practices in Pancreas and Islet Transplantation
International Survey of Clinical Monitoring Practices in Pancreas and Islet Transplantation Open
Background. The long-term outcomes of both pancreas and islet allotransplantation have been compromised by difficulties in the detection of early graft dysfunction at a time when a clinical intervention can prevent further deterioration an…
View article: Sex Disparity in Liver Transplant and Access to Living Donation
Sex Disparity in Liver Transplant and Access to Living Donation Open
These study findings suggest that women can overcome the complex problem of allocation inequity with access to livers from living donors. Women with access only to DDLT were much more unwell than men independent of liver disease at the tim…
View article: Early Allograft Dysfunction After Liver Transplantation With Donation After Circulatory Death and Brain Death Grafts: Does the Donor Type Matter?
Early Allograft Dysfunction After Liver Transplantation With Donation After Circulatory Death and Brain Death Grafts: Does the Donor Type Matter? Open
Background. Early allograft dysfunction (EAD) after liver transplantation has been associated with long-term reduced graft and patient survival. Methods. In this single-center cohort study, we aimed to compare incidence, risk factors, and …
View article: Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes Open
Intrapancreatic trypsin activation by dysregulated macroautophagy/autophagy and pathological exocytosis of zymogen granules (ZGs), along with activation of inhibitor of NFKB/NF-κB kinase (IKK) are necessary early cellular events in pancrea…
View article: Renal Dysfunction After Liver Transplantation: Effect of Donor Type
Renal Dysfunction After Liver Transplantation: Effect of Donor Type Open
Recipients of donation after circulatory death (DCD) grafts are reportedly at higher risk of developing renal dysfunction after liver transplantation (LT). We compared the development of acute kidney injury (AKI) and chronic kidney disease…
View article: Pediatric living donor liver transplantation with large-for-size left lateral segment grafts
Pediatric living donor liver transplantation with large-for-size left lateral segment grafts Open
Usage of "large-for-size" left lateral segment (LLS) liver grafts in children with high graft to recipient weight ratio (GRWR) is controversial due to concerns about increased recipient complications. During the study period, 77 pediatric …