Explanipedia

Identification of a system for hydroxamate xenosiderophore-mediated iron transport in Burkholderia cenocepacia Open

Syakira Mohammed Hussein, Aderonke Sofoluwe, Ameya Paleja, Anne‐Kathrin Duhme‐Klair, Mark S. Thomas · 2024

One of the mechanisms employed by the opportunistic pathogen Burkholderia cenocepacia to acquire the essential element iron is the production and release of two ferric iron chelating compounds (siderophores), ornibactin and pyochelin. Here…

Repeat infections with chlamydia in women may be more transcriptionally active with lower responses from some immune genes Open

Wilhelmina M. Huston, A G Lawrence, Bryan A. Wee, Mark S. Thomas, Peter Timms , et al. · 2022

Chlamydia trachomatis , the most common bacterial sexually transmitted infection worldwide, is responsible for considerable health burden due to its significant sequelae. There are growing concerns about chlamydial treatment and management…

The Burkholderia cenocepacia iron starvation σ factor, OrbS, possesses an on-board iron sensor Open

Aaron T. Butt, Christopher D Banyard, Sayali S. Haldipurkar, Kirsty Agnoli, Muslim Idan Mohsin , et al. · 2022

Burkholderia cenocepacia is an opportunistic pathogen that causes severe infections of the cystic fibrosis (CF) lung. To acquire iron, B. cenocepacia secretes the Fe(III)-binding compound, ornibactin. Genes for synthesis and utilisation of…

Koala cathelicidin PhciCath5 has antimicrobial activity, including against Chlamydia pecorum Open

Emma Peel, Yuanyuan Cheng, Julianne T. Djordjevic, Denis O’Meally, Mark S. Thomas , et al. · 2021

Devastating fires in Australia over 2019–20 decimated native fauna and flora, including koalas. The resulting population bottleneck, combined with significant loss of habitat, increases the vulnerability of remaining koala populations to t…

Chlamydial clinical isolates show subtle differences in persistence phenotypes and growth in vitro Open

Mark S. Thomas, A G Lawrence, Samuel J. Kroon, Lenka A. Vodstrcil, Samuel Phillips , et al. · 2021

Urogenital Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection throughout the world. While progress has been made to better understand how type strains develop and respond to environmental stress in …

Correction to: A role for tetraspanin proteins in regulating fusion induced by Burkholderia thailandensis Open

Atiga Elgawidi, Muslim Idan Mohsin, Fawwaz Fadhil Ali, Amyleigh Watts, Peter N. Monk , et al. · 2020

A role for tetraspanin proteins in regulating fusion induced by Burkholderia thailandensis Open

Atiga Elgawidi, Muslim Idan Mohsin, Fawwaz Fadhil Ali, Amyleigh Watts, Peter N. Monk , et al. · 2020

Burkholderia pseudomallei is the causative agent of melioidosis, a disease with high morbidity that is endemic in South East Asia and northern Australia. An unusual feature of the bacterium is its ability to induce multinucleated giant cel…

Structure and Metal Binding Properties of Chlamydia trachomatis YtgA Open

Zhenyao Luo, Stephanie L. Neville, Rebecca Campbell, Jacqueline R. Morey, Shruti Menon , et al. · 2019

Chlamydia trachomatis is the most common bacterial sexually transmitted infection in developed countries, with an estimated global prevalence of 4.2% in the 15- to 49-year age group. Although infection is asymptomatic in more than 80% of i…

Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition Open

H.L. Spiewak, S. Shastri, Lili Zhang, Stephan Schwager, Leo Eberl , et al. · 2019

Burkholderia cenocepacia is an opportunistic bacterial pathogen that poses a significant threat to individuals with cystic fibrosis by provoking a strong inflammatory response within the lung. It possesses a type VI secretion system (T6SS)…

Elucidating the chlamydial growth characteristics, infection factors, and host responses to persistent chlamydial infection in women Open

Mark S. Thomas · 2019

Distinct Modes of Promoter Recognition by Two Iron Starvation σ Factors with Overlapping Promoter Specificities Open

Kirsty Agnoli, Sayali S. Haldipurkar, Yingzhi Tang, Aaron T. Butt, Mark S. Thomas · 2018

ECF σ factors regulate subsets of bacterial genes in response to environmental stress signals by directing RNA polymerase to promoter sequences known as the −35 and −10 elements. In this work, we identify the −10 and −35 elements that are …

Structural insights into the function of type VI secretion system TssA subunits Open

Samuel R. Dix, H.J. Owen, Ruyue Sun, Asma Hayati Ahmad, S. Shastri , et al. · 2018

TssA from Aeromonas hydrophila: expression, purification and crystallographic studies Open

Samuel R. Dix, Ruyue Sun, Matthew J. Harris, S.L. Batters, Svetlana E. Sedelnikova , et al. · 2018

TssA is a core subunit of the type VI secretion system, which is a major player in interspecies competition in Gram-negative bacteria. Previous studies on enteroaggregative Escherichia coli TssA suggested that it is comprised of three puta…

TssA from Burkholderia cenocepacia: expression, purification, crystallization and crystallographic analysis Open

H.J. Owen, Ruyue Sun, Asma Hayati Ahmad, Svetlana E. Sedelnikova, Patrick J. Baker , et al. · 2018

TssA is a core component of the type VI secretion system, and phylogenetic analysis of TssA subunits from different species has suggested that these proteins fall into three distinct clades. Whilst representatives of two clades, TssA1 and …

Corrigendum: Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species Open

Aaron T. Butt, Mark S. Thomas · 2018

CORRECTION article Front. Cell. Infect. Microbiol., 24 August 2018Sec. Molecular Bacterial Pathogenesis Volume 8 - 2018 | https://doi.org/10.3389/fcimb.2018.00305

A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women Open

Bryan A. Wee, Mark S. Thomas, Emma L. Sweeney, Francesca D. Frentiu, Melanie Samios , et al. · 2017

Background We know very little about the microbiota inhabiting the upper female reproductive tract and how it impacts on fertility. Aims This pilot study aimed to examine the vaginal, cervical and endometrial microbiota for women with a hi…

Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species Open

Aaron T. Butt, Mark S. Thomas · 2017

Burkholderia is a genus within the β-Proteobacteriaceae that contains at least 90 validly named species which can be found in a diverse range of environments. A number of pathogenic species occur within the genus. These inclu…

Virulence profile: Mark Thomas Open

Mark S. Thomas · 2017

I was born in central London, but my parents moved to the eastern suburbs when I was still an infant. I was the eldest of four brothers and had a normal childhood. I was very keen on soccer from an...

Editorial Board Open

Pierre Cornélis, Sonja‐Verena Albers, Simon Andrew, Scott A. Beatson, Wilbert Bitter , et al. · 2016

An efficient system for the generation of marked genetic mutants in members of the genus Burkholderia Open

S. Shastri, H.L. Spiewak, Aderonke Sofoluwe, Vigdis A. Eidsvaag, Atif H. Asghar , et al. · 2016

To elucidate the function of a gene in bacteria it is vital that targeted gene inactivation (allelic replacement) can be achieved. Allelic replacement is often carried out by disruption of the gene of interest by insertion of an antibiotic…

Editorial Board Open

Pierre Cornélis, Sonja‐Verena Albers, Simon Andrew, Scott A. Beatson, Wilbert Bitter , et al. · 2016

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