Marc Schneider
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View article: Stimuli‐Responsive 3D‐Printed Structurally Colored Materials Based on Core–Shell Particle Architectures
Stimuli‐Responsive 3D‐Printed Structurally Colored Materials Based on Core–Shell Particle Architectures Open
In additive manufacturing via fused deposition modeling (FDM), no easily scalable process for producing intelligent, e.g., pH‐responsive, structurally colored filaments is known yet. This work presents the preparation of a structurally col…
View article: Impact of Formulation Ingredient Compatibility on Encapsulation of Hydrophobic Substances in Polymeric Nanocarriers Prepared by Nanoprecipitation
Impact of Formulation Ingredient Compatibility on Encapsulation of Hydrophobic Substances in Polymeric Nanocarriers Prepared by Nanoprecipitation Open
As a versatile platform technology, polymer nanoparticles enable the effective delivery of hydrophobic drug substances. To achieve therapeutic efficacy, adequate drug loading is required, which requires a quantitative understanding of form…
View article: The Pivotal Step of Structure Formation and Oil-Binding Capacity of Polyglucosamine
The Pivotal Step of Structure Formation and Oil-Binding Capacity of Polyglucosamine Open
View article: Development of probiotic microencapsulated Limosilactobacillus reuteri films using mucoadhesive polymers as a delivery system – strategies to improve bacterial viability
Development of probiotic microencapsulated Limosilactobacillus reuteri films using mucoadhesive polymers as a delivery system – strategies to improve bacterial viability Open
View article: Probiotics-embedded polymer films for oral health: Development, characterization, and therapeutic potential
Probiotics-embedded polymer films for oral health: Development, characterization, and therapeutic potential Open
The oral microbiome plays a crucial role in maintaining homeostasis, and microbial imbalances contribute to diseases such as periodontitis. Probiotic strains such as Lactobacillus rhamnosus and Lactobacillus reuteri have shown potential in…
View article: The Role of Nanoparticle Elasticity on Biological Hydrogel Penetration
The Role of Nanoparticle Elasticity on Biological Hydrogel Penetration Open
The latest advancements in nanomedicine have led to increased therapeutic efficacy and reduced complications. However, nanoparticle penetration is significantly influenced by biological hydrogels, such as mucus, the extracellular matrix, b…
View article: Exogenous dsRNA made accessible to Dicer by two eukaryotic RNA-dependent RNA polymerases
Exogenous dsRNA made accessible to Dicer by two eukaryotic RNA-dependent RNA polymerases Open
Discrimination of self from non-self RNA is a critical requirement for any cell to respond to infections and to maintain cellular integrity. We report novel functions for two RNA-dependent RNA polymerases (RDRs) in Paramecium in the detect…
View article: Evaporation-triggered nanoprecipitation for PLGA nanoparticle formation using a spinning-disc system
Evaporation-triggered nanoprecipitation for PLGA nanoparticle formation using a spinning-disc system Open
View article: Impact of the COVID-19 pandemic on prehospital emergency medical service: a scoping review
Impact of the COVID-19 pandemic on prehospital emergency medical service: a scoping review Open
Background The COVID-19 pandemic has had an unprecedented impact on healthcare systems worldwide. Emergency medical services (EMS) frequently served as the sole point of contact for individuals in need of assistance or emergency support. T…
View article: Comparative Analysis of Two Elastic Types of Surface‐Crosslinked Gelatin Nanoparticles as Suitable Systems for Macromolecular Drug Delivery
Comparative Analysis of Two Elastic Types of Surface‐Crosslinked Gelatin Nanoparticles as Suitable Systems for Macromolecular Drug Delivery Open
With a steadily rising number of novel biopharmaceuticals in development, the demand for applicable delivery systems for macromolecular drugs persists. Polymeric nanoparticles, consisting of the natural product gelatin, present beneficial …
View article: Menadione as Antibiotic Adjuvant Against P. aeruginosa: Mechanism of Action, Efficacy and Safety
Menadione as Antibiotic Adjuvant Against P. aeruginosa: Mechanism of Action, Efficacy and Safety Open
Background/Objectives: Antibiotic resistance in chronic lung infections caused by Pseudomonas aeruginosa requires alternative approaches to improve antibiotic efficacy. One promising approach is the use of adjuvant compounds that complemen…
View article: pH- and Anion-Responsive Poly(1-vinylimidazole) Opal Films for Smart Sensing
pH- and Anion-Responsive Poly(1-vinylimidazole) Opal Films for Smart Sensing Open
View article: Scalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties
Scalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties Open
Background and Objectives: Drug delivery systems (DDSs) offer efficient treatment solutions to challenging diseases such as central nervous system (CNS) diseases by bypassing biological barriers such as the blood–brain barrier (BBB). Among…
View article: Proteomic Profiling of Macrophages: Effects of Inflammatory Activation and Anti-Inflammatory Treatment with Ibd Therapeutics
Proteomic Profiling of Macrophages: Effects of Inflammatory Activation and Anti-Inflammatory Treatment with Ibd Therapeutics Open
View article: A3.1 - Development of a Biosensor Platform Measuring the Electrical Resistance in a Tailor-Made System for Biological Barriers to Assess the Barrier Integrity
A3.1 - Development of a Biosensor Platform Measuring the Electrical Resistance in a Tailor-Made System for Biological Barriers to Assess the Barrier Integrity Open
View article: Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals
Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals Open
Central nervous system diseases negatively affect patients and society. Providing successful noninvasive treatments for these diseases is challenging because of the presence of the blood–brain barrier. While protecting the brain’s homeosta…
View article: Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis
Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis Open
Pulmonary fibrosis, a disabling lung disease, results from the fibrotic transformation of lung tissue. This fibrotic transformation leads to a deterioration of lung capacity, resulting in significant respiratory distress and a reduction in…
View article: Nanostructured metamaterials for the thermal and electromagnetic isolation of cryostats
Nanostructured metamaterials for the thermal and electromagnetic isolation of cryostats Open
Póster presentado en SPIE Astronomical Telescopes + Instrumentation, celebrado en Yokohama (Japón), del 16 al 21 de junio de 2024
View article: Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection. Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?
Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection. Would Nanocarriers Complement Biofilm Disruption or Pave Its Road? Open
The biofilm-destructive potential of QSI/SLNs/AL inhalation is promising for site-specific biofilm-targeted interventional CF therapy. Nevertheless, the intrinsic/extrinsic fundamentals of nanocarrier-biofilm interactions require further i…
View article: Aspherical, Nano-Structured Drug Delivery System with Tunable Release and Clearance for Pulmonary Applications
Aspherical, Nano-Structured Drug Delivery System with Tunable Release and Clearance for Pulmonary Applications Open
Addressing the challenge of efficient drug delivery to the lungs, a nano-structured, microparticulate carrier system with defined and customizable dimensions has been developed. Utilizing a template-assisted approach and capillary forces, …
View article: Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems
Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems Open
Nanoparticles have shown an enormous potential as drug delivery systems in the lab. However, translation to the clinics or even market approval often fails. So far, the reason for this discrepancy is manifold. Physicochemical properties su…
View article: Impact of mucus modulation by N-acetylcysteine on nanoparticle toxicity
Impact of mucus modulation by N-acetylcysteine on nanoparticle toxicity Open
Human respiratory mucus is a biological hydrogel that forms a protective barrier for the underlying epithelium. Modulation of the mucus layer has been employed as a strategy to enhance transmucosal drug carrier transport. However, a drawba…
View article: A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy Open
Abnormal α-synuclein (α-syn) aggregation characterizes α-synucleinopathies, including Parkinson's disease (PD) and multiple system atrophy (MSA). However, no suitable positron emission tomography (PET) radiotracer for imaging α-syn in PD a…
View article: Nanostructured Microparticles Repolarize Macrophages and Induce Cell Death in an In Vitro Model of Tumour-Associated Macrophages
Nanostructured Microparticles Repolarize Macrophages and Induce Cell Death in an In Vitro Model of Tumour-Associated Macrophages Open
Macrophages (MΦs) in their pro-inflammatory state (M1) suppress tumour growth, while tumour-associated MΦs (TAMs) can promote tumour progression. The aim of this study was to test the hypothesis that targeted delivery of the immune activat…
View article: The Potential of Epigallocatechin-3-gallate (EGCG) as Complementary Medicine for the Treatment of Inflammatory Bowel Disease
The Potential of Epigallocatechin-3-gallate (EGCG) as Complementary Medicine for the Treatment of Inflammatory Bowel Disease Open
Complementary and alternative medicine has the potential to enrich conventional therapy to improve the treatment of various diseases. Patients that suffer from inflammatory bowel disease, which requires a constant need for medication, have…
View article: Planar fiber-chip-coupling using angle-polished polarization maintaining fibers
Planar fiber-chip-coupling using angle-polished polarization maintaining fibers Open
We report on our latest developments of a planar fiber-chip-coupling scheme, using angle polished, polarization maintaining (PM) fibers. Most integrated photonic chip components are polarization sensitive and a suitable way to launch sever…
View article: The Effect of Elasticity of Gelatin Nanoparticles on the Interaction with Macrophages
The Effect of Elasticity of Gelatin Nanoparticles on the Interaction with Macrophages Open
Gelatin is a biocompatible, biodegradable, cheap, and nontoxic material, which is already used for pharmaceutical applications. Nanoparticles from gelatin (GNPs) are considered a promising delivery system for hydrophilic and macromolecular…
View article: Inflammatory bowel disease addressed by Caco-2 and monocyte-derived macrophages: an opportunity for an in vitro drug screening assay
Inflammatory bowel disease addressed by Caco-2 and monocyte-derived macrophages: an opportunity for an in vitro drug screening assay Open
Inflammatory bowel disease (IBD) is a widespread disease, affecting a growing demographic. The treatment of chronic inflammation located in the GI-tract is dependent on the severity; therefore, the IBD treatment pyramid is commonly applied…
View article: Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading
Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading Open
Tuning the elastic properties of nanoparticles intended to be used in drug delivery is of great interest. To this end, different potential formulations are developed since the particle elasticity is affecting the in vitro and in vivo perfo…
View article: In Vitro, Ex Vivo, and In Vivo Evaluation of Nanoparticle-Based Topical Formulation Against Candida albicans Infection
In Vitro, Ex Vivo, and In Vivo Evaluation of Nanoparticle-Based Topical Formulation Against Candida albicans Infection Open
Ketoconazole is commonly used in the treatment of topical fungal infections. The therapy requires frequent application for several weeks. Systemic side effects, allergic reactions, and prolonged treatment are often associated with non-comp…