Mark Schvartzman
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View article: A high -quality and -throughput colloidal lithography by mechanical assembly and ice-based transfer
A high -quality and -throughput colloidal lithography by mechanical assembly and ice-based transfer Open
Colloidal lithography has emerged as a promising alternative to conventional nanofabrication techniques, offering the ability to create nanoscale patterns in a cost-effective and scalable manner. However, it has been so far limited by defe…
View article: Mechanostimulatory Platform for Improved CAR T Cell Immunotherapy
Mechanostimulatory Platform for Improved CAR T Cell Immunotherapy Open
Chimeric Antigen Receptor T (CAR T) cell immunotherapy has revolutionized cancer treatment, yet it is hindered by rapid T‐cell exhaustion caused by uncontrolled activation during CAR generation. Leveraging insights into T‐cell mechanosensi…
View article: Multifunctional Nanoscale Platform for the Study of T Cell Receptor Segregation
Multifunctional Nanoscale Platform for the Study of T Cell Receptor Segregation Open
T cells respond not only to biochemical stimuli transmitted through their activating, costimulatory, and inhibitory receptors but also to biophysical aspects of their environment, including the receptors' spatial arrangement. While these r…
View article: Nanocomposite coatings for the prevention of surface contamination by coronavirus
Nanocomposite coatings for the prevention of surface contamination by coronavirus Open
The current Covid-19 pandemic has a profound impact on all aspects of our lives. Aside from contagion by aerosols, the presence of the SARS-CoV-2 is ubiquitous on surfaces that millions of people handle daily. Therefore, controlling this p…
View article: Molecular-scale spatio-chemical control of the activating-inhibitory signal integration in NK cells
Molecular-scale spatio-chemical control of the activating-inhibitory signal integration in NK cells Open
Molecular devices for the spatial control of activating and inhibitory receptors help in their signal integration.
View article: Second-harmonic generation from subwavelength metal heterodimers
Second-harmonic generation from subwavelength metal heterodimers Open
We experimentally study the optical second-harmonic generation (SHG) from deep subwavelength gold-silver heterodimers, and silver-silver and gold-gold homodimers. Our results indicate a heterodimer SHG that is an order of magnitude more in…
View article: Surface plasticizing of chalcogenide glasses: a route for direct nanoimprint with multifunctional antireflective and highly hydrophobic structures
Surface plasticizing of chalcogenide glasses: a route for direct nanoimprint with multifunctional antireflective and highly hydrophobic structures Open
Chalcogenide glasses are attractive materials for optical applications. However, these applications often require pattering of the surface with functional micro-/ nanostructures, which is challenging by traditional microfabrication. Here, …
View article: Molecular Scale Spatio-Chemical Control of the Activating-Inhibitory Signal Integration in NK Cells
Molecular Scale Spatio-Chemical Control of the Activating-Inhibitory Signal Integration in NK Cells Open
The role of the spatial juxtaposition between activating and inhibitory receptors in cytotoxic lymphocytes has been strongly debated in the context of the inhibition of immune signaling. The challenge in addressing this problem was so far …
View article: Mechanical Regulation of the Cytotoxic Activity of Natural Killer Cells
Mechanical Regulation of the Cytotoxic Activity of Natural Killer Cells Open
Mechanosensing has been recently explored for T cells and B cells and is believed to be part of their activation mechanism. Here, we explore the mechanosensing of the third type of lymphocytes – Natural Killer (NK) cells, by showing that t…
View article: Second-harmonic generation due to coulomb-like interaction in a heterodimer of subwavelength dimensions
Second-harmonic generation due to coulomb-like interaction in a heterodimer of subwavelength dimensions Open
We experimentally study the optical second harmonic generation (SHG) from deep subwavelength gold-silver heterodimer and silver-silver and gold-gold homodimers. Our results show that the SHG from the heterodimer is about an order of magnit…
View article: In-Plane Nanowires with Arbitrary Shapes on Amorphous Substrates by Artificial Epitaxy
In-Plane Nanowires with Arbitrary Shapes on Amorphous Substrates by Artificial Epitaxy Open
The challenge of nanowire assembly is still one of the major obstacles toward their efficient integration into functional systems. One strategy to overcome this obstacle is the guided growth approach, in which the growth of in-plane nanowi…
View article: Advanced Materials and Devices for the Regulation and Study of NK Cells
Advanced Materials and Devices for the Regulation and Study of NK Cells Open
Natural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytot…
View article: Assessment of intraocular pressure sensing using an implanted reflective flexible membrane
Assessment of intraocular pressure sensing using an implanted reflective flexible membrane Open
Glaucoma is a neurodegenerative condition that is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is the main cause for the development of the disease. The symptoms of this form, such as deteriora…