Mark Sicking
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Prognostic marker Musashi-2 modulates DNA damage response and radioresistance in diffuse large B-cell lymphoma Open
Introduction Treatment resistance is a major hurdle in diffuse large B-cell lymphoma (DLBCL) therapy. Here, we assessed the relevance of the Musashi (MSI) RNA-binding protein family for DLBCL treatment efficacy. As important gene expressio…
Musashi inhibitor Ro 08–2750 attenuates triple-negative breast cancer cell proliferation and migration and acts as a novel chemo- and radiosensitizer Open
Our results indicate that Musashi protein inhibition may attenuate tumor progression and sensitize cells to conventional breast cancer therapy, underlining the therapeutic potential of this approach.
The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance Open
RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA-binding proteins are involved…
Tumor suppressor miR-218 directly targets epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer, sensitizing cells to irradiation Open
Purpose MicroRNA-218 (miR-218) is a key regulator of numerous processes relevant to tumor progression. In the present study, we aimed to characterize the relationship between miR-218 and the Epidermal Growth Factor Receptor (EGFR) as well …
Proteomics Identifies Substrates and a Novel Component in hSnd2-Dependent ER Protein Targeting Open
Importing proteins into the endoplasmic reticulum (ER) is essential for about 30% of the human proteome. It involves the targeting of precursor proteins to the ER and their insertion into or translocation across the ER membrane. Furthermor…
Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting Open
SUMMARY Protein import into the endoplasmic reticulum (ER) is essential for about 30% of the human proteome. It involves targeting of precursor proteins to the ER and insertion into or translocation across the ER membrane. Furthermore, it …
View article: Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin Open
The human Sec61 complex is a widely distributed and abundant molecular machine. It resides in the membrane of the endoplasmic reticulum to channel two types of cargo: protein substrates and calcium ions. The SEC61A1 gene encodes for the po…
The Molecular Biodiversity of Protein Targeting and Protein Transport Related to the Endoplasmic Reticulum Open
Looking at the variety of the thousands of different polypeptides that have been focused on in the research on the endoplasmic reticulum from the last five decades taught us one humble lesson: no one size fits all. Cells use an impressive …
Lights, Camera, Interaction: Studying Protein–Protein Interactions of the ER Protein Translocase in Living Cells Open
Various landmark studies have revealed structures and functions of the Sec61/SecY complex in all domains of live demonstrating the conserved nature of this ancestral protein translocase. While the bacterial homolog of the Sec61 complex res…
View article: Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex
Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex Open
The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the roughly one hundred components, which are involved in protein import …
<span>hS</span>nd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells Open
Recently, understanding of protein targeting to the endoplasmic reticulum ( ER ) was expanded by the discovery of multiple pathways that function in parallel to the signal recognition particle ( SRP ). Guided entry of tail‐anchored protein…