Mark Sidhom
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View article: Implementation of an automated contour quality assurance tool within the TROG 18.01 NINJA trial
Implementation of an automated contour quality assurance tool within the TROG 18.01 NINJA trial Open
These findings support the feasibility of automated contour QA in multicentre trials and offer guidance for future implementation at scale.
View article: Planning for Preservation: Feasibility of Erectile Tissue Sparing During Prostate Stereotactic Radiotherapy
Planning for Preservation: Feasibility of Erectile Tissue Sparing During Prostate Stereotactic Radiotherapy Open
Introduction An estimated one in six Australian men are diagnosed with prostate cancer (PC) by age 85. Cure and quality of life are the modern definitions of successful cancer treatment, and preservation of continence and sexual function r…
View article: Anatomy of the Gallbladder
Anatomy of the Gallbladder Open
This chapter, Anatomy of the Gallbladder, serves as a foundational exploration of the gallbladder’s structure, positioning, and physiological significance within the hepatobiliary system. It delves into the organ’s gross anatomy, histologi…
View article: Dosimetric Clues to Addressing Urinary Toxicity Following Stereotactic Prostate Radiation Therapy
Dosimetric Clues to Addressing Urinary Toxicity Following Stereotactic Prostate Radiation Therapy Open
Prostate SBRT delivered as a virtual high-dose-rate boost is well tolerated overall. However, delayed GU toxicity is experienced by a significant minority of patients. Additional bladder constraints including D10 cc < 17 Gy and D15 cc < 15…
View article: Multimodal therapy and precision-imaging extends the limits of treatment for a patient with initially unresectable synchronous colorectal liver metastases
Multimodal therapy and precision-imaging extends the limits of treatment for a patient with initially unresectable synchronous colorectal liver metastases Open
The cancer journey of a young patient who presented with an obstructing metastatic (Stage 4) colon cancer is described. The addition of bevacizumab to an established chemotherapy regimen of 5-fluorouracil, folinic acid and oxaliplatin (FOL…
View article: Longitudinal quantitative MRI in prostate cancer after radiation therapy with and without androgen deprivation therapy
Longitudinal quantitative MRI in prostate cancer after radiation therapy with and without androgen deprivation therapy Open
Quantitative MRI show promise for reliably detecting treatment response within 18-months post-RT. Future clinical trials should validate the potential of Ktrans and HS by correlating these parameters with treatment outcomes.
View article: The TROG 15.01 stereotactic prostate adaptive radiotherapy utilizing kilovoltage intrafraction monitoring (SPARK) clinical trial database
The TROG 15.01 stereotactic prostate adaptive radiotherapy utilizing kilovoltage intrafraction monitoring (SPARK) clinical trial database Open
Purpose The US National Institutes of Health state that Sharing of clinical trial data has great potential to accelerate scientific progress and ultimately improve public health by generating better evidence on the safety and effectiveness…
View article: Treatment accuracy of standard linear accelerator-based prostate SBRT: the delivered dose assessment of patients treated within two major clinical trials using an in-house position monitoring system
Treatment accuracy of standard linear accelerator-based prostate SBRT: the delivered dose assessment of patients treated within two major clinical trials using an in-house position monitoring system Open
Background and purpose The purpose of this study was to assess the dosimetric improvements achieved in prostate stereotactic body radiotherapy (SBRT) treatment within the PROMETHEUS and NINJA trials using an in-house real-time position mon…
View article: Uncertainty estimation using a 3D probabilistic U-Net for segmentation with small radiotherapy clinical trial datasets
Uncertainty estimation using a 3D probabilistic U-Net for segmentation with small radiotherapy clinical trial datasets Open
We demonstrated that training auto-segmentation models which can estimate aleatoric and epistemic uncertainty using limited datasets is possible. Having the model estimate prediction confidence is important to understand for which unseen c…
View article: Evaluating the relationship between contouring variability and modelled treatment outcome for prostate bed radiotherapy
Evaluating the relationship between contouring variability and modelled treatment outcome for prostate bed radiotherapy Open
Objectives. Contouring similarity metrics are often used in studies of inter-observer variation and automatic segmentation but do not provide an assessment of clinical impact. This study focused on post-prostatectomy radiotherapy and aimed…
View article: Prostate Virtual High-dose-rate Brachytherapy Boost: 5-Year Results from the PROMETHEUS Prospective Multicentre Trial
Prostate Virtual High-dose-rate Brachytherapy Boost: 5-Year Results from the PROMETHEUS Prospective Multicentre Trial Open
The PROMETHEUS trial investigated noninvasive high-dose precision radiotherapy combined with conventional radiotherapy in patients with prostate cancer. We found that this new technique was well tolerated and resulted in better cancer cont…
View article: Opioid analgesics for nociceptive cancer pain: A comprehensive review
Opioid analgesics for nociceptive cancer pain: A comprehensive review Open
Pain is one of the most burdensome symptoms in people with cancer, and opioid analgesics are considered the mainstay of cancer pain management. For this review, the authors evaluated the efficacy and toxicities of opioid analgesics compare…
View article: Robust optimization for prostate radiotherapy: Assessment of delivered dose by incorporating intrafraction prostate position deviations
Robust optimization for prostate radiotherapy: Assessment of delivered dose by incorporating intrafraction prostate position deviations Open
Aim To assess the robustness of the dose delivered to the clinical target volume (CTV) using planning target volume (PTV) based and robust optimization planning approaches in localized prostate cancer radiotherapy. Methods Retrospective da…
View article: Surgical Training in the United Kingdom's National Health Service: The Challenges for International Medical Graduates
Surgical Training in the United Kingdom's National Health Service: The Challenges for International Medical Graduates Open
This study showed that there is a need to support international doctors who wish to start or continue their training in the UK. Furthermore, IMGs should expect to face several challenges when applying to work in the UK NHS.
View article: SP10.1 Post operative complications and functional outcome after ventral mesh and suture rectopexy for rectal prolapse: a single centre observational study
SP10.1 Post operative complications and functional outcome after ventral mesh and suture rectopexy for rectal prolapse: a single centre observational study Open
Aims Laparoscopic ventral mesh rectopexy (LVMR) is a technique gaining more recognition for the management of pelvic floor disorders, such as external rectal prolapse (ERP), high grade internal rectal prolapse (IRP) and rectocele. The aim …
View article: Assessment of intrafraction motion and its dosimetric impact on prostate radiotherapy using an in-house developed position monitoring system
Assessment of intrafraction motion and its dosimetric impact on prostate radiotherapy using an in-house developed position monitoring system Open
Purpose To implement an in-house developed position monitoring software, SeedTracker, for conventional fractionation prostate radiotherapy, and study the effect on dosimetric impact and intrafraction motion. Methods Thirty definitive prost…
View article: Reducing the margin in prostate radiotherapy: optimizing radiotherapy with a general-purpose linear accelerator using an in-house position monitoring system
Reducing the margin in prostate radiotherapy: optimizing radiotherapy with a general-purpose linear accelerator using an in-house position monitoring system Open
Purpose To study the feasibility of optimizing the Clinical Target Volume to Planning Target Volume (CTV-PTV) margin in prostate radiotherapy(RT) with a general-purpose linear accelerator using an in-house developed position monitoring sys…
View article: Patterns of practice regarding use of radiation therapy following radical prostatectomy: A survey of Radiation Oncologists and Urologists in Australia and New Zealand
Patterns of practice regarding use of radiation therapy following radical prostatectomy: A survey of Radiation Oncologists and Urologists in Australia and New Zealand Open
Introduction This study aimed to investigate the patterns of practices of radiation oncologists (ROs) and urologists in Australia and New Zealand with respect to the utilisation of post‐prostatectomy radiation therapy (RT) and help guide t…
View article: Virtual HDR Boost for Prostate Cancer: Rebooting a Classic Treatment Using Modern Tech
Virtual HDR Boost for Prostate Cancer: Rebooting a Classic Treatment Using Modern Tech Open
Prostate cancer (PC) is the most common malignancy in men. Internal radiotherapy (brachytherapy) has been used to treat PC successfully for over a century. In particular, there is level-one evidence of the benefits of using brachytherapy t…
View article: Genitourinary Quality-of-Life Comparison Between Urethral Sparing Prostate Stereotactic Body Radiation Therapy Monotherapy and Virtual High-Dose-Rate Brachytherapy Boost
Genitourinary Quality-of-Life Comparison Between Urethral Sparing Prostate Stereotactic Body Radiation Therapy Monotherapy and Virtual High-Dose-Rate Brachytherapy Boost Open
Even in the presence of urethral sparing, the higher BED delivered in the Boost schedule may have a small adverse effect on GU QoL compared with Monotherapy. However, this did not translate to statistically significant differences in minim…
View article: Encouraging Patients to Ask Questions: Development and Pilot Testing of a Question Prompt List for Patients Undergoing a Biopsy for Suspected Prostate Cancer
Encouraging Patients to Ask Questions: Development and Pilot Testing of a Question Prompt List for Patients Undergoing a Biopsy for Suspected Prostate Cancer Open
This study assessed the acceptability and feasibility of a question prompt list (QPL) to facilitate informed treatment decision-making in men with suspected localised prostate cancer, which involves values-based choices between options wit…
View article: Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data
Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data Open
KBP created high quality PPRT plans using the data from a multicentre clinical trial in a single optimisation. It is a powerful tool for utilisation in clinical trials for patient specific QA, to reduce dose to surrounding OARs and variati…
View article: FASTRACK II magnetic resonance imaging sub-study Diffusion and perfusion biomarkers for renal SABR response
FASTRACK II magnetic resonance imaging sub-study Diffusion and perfusion biomarkers for renal SABR response Open
Stereotactic ablative body radiotherapy (SABR) is demonstrating good local control for patients with inoperable primary renal cell carcinoma. In a previous pilot study we identified magnetic resonance imaging (MRI) early response biomarker…