Mark Spear
YOU?
Author Swipe
View article: Suppression of viral rebound by a Rev-dependent lentiviral particle in SIV-infected rhesus macaques
Suppression of viral rebound by a Rev-dependent lentiviral particle in SIV-infected rhesus macaques Open
Persistence of human immunodeficiency virus (HIV) reservoirs prevents viral eradication, and consequently HIV-infected patients require lifetime treatment with antiretroviral therapy (ART) [1–5]. Currently, there are no effective therapeut…
View article: CT109-SN-38, a Novel Antibody-drug Conjugate with Dual Specificity forCEACAM5 and 6, Elicits Potent Killing of Pancreatic Cancer Cells
CT109-SN-38, a Novel Antibody-drug Conjugate with Dual Specificity forCEACAM5 and 6, Elicits Potent Killing of Pancreatic Cancer Cells Open
Background: CEACAM5 and CEACAM6 are glycosylphosphatidylinositol (GPI)- linked members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family, which are frequently upregulated in epithelial cancers where they contri…
View article: Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α <sub>4</sub> β <sub>7</sub> integrin antibody
Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α <sub>4</sub> β <sub>7</sub> integrin antibody Open
We demonstrate an HIV-mediated dysregulation of cofilin in CD4 T cells and propose therapeutics to restore T cell motility.
View article: Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1
Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1 Open
A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity by hijacking chemokine coreceptor signaling, which activates…