Mark Stoneley
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View article: ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging Open
The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we s…
Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress Open
During the translation surveillance mechanism known as ribosome-associated quality control, the ASC-1 complex (ASCC) disassembles ribosomes stalled on the mRNA. Here, we show that there are two distinct classes of stalled ribosome. Ribosom…
The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction Open
The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth, integrating multiple signalling cues and pathways. Key among the downstream activities of mTOR is the control of the protein synthesis machinery. This is achi…
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I Open
Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulti…
Author response: Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Disruption of mito…
Full-length NF-κB repressing factor contains an XRN2 binding domain Open
NF-κB repressing factor (NKRF) was recently identified as an RNA binding protein that together with its associated proteins, the 5′–3′ exonuclease XRN2 and the helicase DHX15, is required to process the precursor ribosomal RNA. XRN2 is a m…
Signaling from mTOR to eIF2α mediates cell migration in response to the chemotherapeutic doxorubicin Open
Doxorubicin-induced DNA damage promotes cancer cell migration downstream of eIF2α phosphorylation.
Identification of the RNA polymerase I-RNA interactome Open
Ribosome biogenesis is a complex process orchestrated by a host of ribosome assembly factors. Although it is known that many of the proteins involved in this process have RNA binding activity, the full repertoire of proteins that interact …