Mark Stubbs
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View article: Front Cover: A Degron Blocking Strategy Towards Improved CRL4<sup>CRBN</sup> Recruiting PROTAC Selectivity (ChemBioChem 23/2023)
Front Cover: A Degron Blocking Strategy Towards Improved CRL4<sup>CRBN</sup> Recruiting PROTAC Selectivity (ChemBioChem 23/2023) Open
E3 ligase mediated targeted protein degradation is an ever more important area in drug discovery. In the case of cereblon two avenues exist; either heterobifunctional PROTACs, or discrete cereblon ligands that induce a specific neosubstrat…
View article: Determination of Ligand-Binding Affinity (<i>K</i><sub>d</sub>) Using Transverse Relaxation Rate (<i>R</i><sub>2</sub>) in the Ligand-Observed <sup>1</sup>H NMR Experiment and Applications to Fragment-Based Drug Discovery
Determination of Ligand-Binding Affinity (<i>K</i><sub>d</sub>) Using Transverse Relaxation Rate (<i>R</i><sub>2</sub>) in the Ligand-Observed <sup>1</sup>H NMR Experiment and Applications to Fragment-Based Drug Discovery Open
High hit rates from initial ligand-observed NMR screening can make it challenging to prioritize which hits to follow up, especially in cases where there are no available crystal structures of these hits bound to the target proteins or othe…
View article: A Degron Blocking Strategy Towards Improved CRL4<sup>CRBN</sup> Recruiting PROTAC Selectivity**
A Degron Blocking Strategy Towards Improved CRL4<sup>CRBN</sup> Recruiting PROTAC Selectivity** Open
Small molecules inducing protein degradation are important pharmacological tools to interrogate complex biology and are rapidly translating into clinical agents. However, to fully realise the potential of these molecules, selectivity remai…
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In a prospective biopsy-stratified clinical trial, we combined detailed molecular profiling and drug screening in…
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In a prospective biopsy-stratified clinical trial, we combined detailed molecular profiling and drug screening in…
View article: Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition Open
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
View article: Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure Legends 1-13, Methods from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 13 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figures 1-3 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
The Wnt signaling pathway is frequently deregulated in cancer due to mutations in genes encoding APC, β-catenin, and axin. To identify small-molecule inhibitors of Wnt signaling as potential therapeutics, a diverse chemical library was scr…
View article: Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 5 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 4 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
The Wnt signaling pathway is frequently deregulated in cancer due to mutations in genes encoding APC, β-catenin, and axin. To identify small-molecule inhibitors of Wnt signaling as potential therapeutics, a diverse chemical library was scr…
View article: Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
View article: Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription Open
Supplementary Figure 12 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription