Mark A. Sussman
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View article: Myocardial Infarction Injury Is Exacerbated by Nicotine in Vape Aerosol Exposure
Myocardial Infarction Injury Is Exacerbated by Nicotine in Vape Aerosol Exposure Open
Background Vaping is touted as a safer alternative to traditional cigarette smoking, but the full spectrum of harm reduction versus comparable risk remains unresolved. Elevated bioavailability of nicotine in vape aerosol together with know…
View article: Cardiac p16 Expression Following Vape Exposure with Nicotine Shows Sex-Specific Induction in Males but not Females
Cardiac p16 Expression Following Vape Exposure with Nicotine Shows Sex-Specific Induction in Males but not Females Open
Vaping is marketed as a safe alternative to traditional cigarette smoking, but multiple studies demonstrate deleterious cardiopulmonary effects including cardiac function decline and fibrotic remodeling with alveolar size enlargement. Nico…
View article: Myocardial infarction injury is exacerbated by nicotine in vape aerosol exposure
Myocardial infarction injury is exacerbated by nicotine in vape aerosol exposure Open
Rationale Vaping is touted as a safer alternative to traditional cigarette smoking but the full spectrum of harm reduction versus comparable risk remains unresolved. Elevated bioavailability of nicotine in vape aerosol together with known …
View article: Polyploidy in Cardiomyocytes: Machine Learning for Single Cell Analyses
Polyploidy in Cardiomyocytes: Machine Learning for Single Cell Analyses Open
Understanding the dynamics of cardiomyocyte ploidy is of paramount importance for deciphering the cellular mechanisms propelling cardiac development,1 regeneration,2 and disease.3 Cardiomyocytes possess diverse ploidy levels that can vary …
View article: Using the Theory of Planned Behavior to Anticipate DIY E-juice Mixing among Young Adult International E-cigarette Users
Using the Theory of Planned Behavior to Anticipate DIY E-juice Mixing among Young Adult International E-cigarette Users Open
Background: Trends in young adult use of electronic nicotine delivery systems (ENDS) and experimentation with do-it-yourself (DIY) e-juice mixing are growing around the world. Theoretical frameworks for examining secondary behaviors (i.e.,…
View article: Adaptive Mesh Refinement Large Eddy Simulation of the Supercritical Carbon Dioxide Round Turbulent Jet
Adaptive Mesh Refinement Large Eddy Simulation of the Supercritical Carbon Dioxide Round Turbulent Jet Open
Supercritical carbon dioxide (sCO2) is of interest to a range of engineering problems, including carbon capture, utilization, and storage (CCUS) as well as advanced cycles for power generation. Non-ideal variations in physical properties o…
View article: Surface Lin28A expression consistent with cellular stress parallels indicators of senescence
Surface Lin28A expression consistent with cellular stress parallels indicators of senescence Open
Aims Declining cellular functional capacity resulting from stress or ageing is a primary contributor to impairment of myocardial performance. Molecular pathway regulation of biological processes in cardiac interstitial cells (CICs) is pivo…
View article: Cardiovascular consequences of vaping
Cardiovascular consequences of vaping Open
Purpose of review Vaping activity continues to increase worldwide. Promoted as a ‘healthier’ alternative to traditional smoking, emerging evidence indicates ‘healthier’ should not be confused with ‘harmless’. Direct inhalation exposure of …
View article: Transient reprogramming primes the heart for repair
Transient reprogramming primes the heart for repair Open
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View article: Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress
Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress Open
Vaping of flavored liquids has been touted as safe alternative to traditional cigarette smoking with decreased health risks. The popularity of vaping has dramatically increased over the last decade, particularly among teenagers who incorpo…
View article: Fundamentals of Vaping-Associated Pulmonary Injury Leading to Severe Respiratory Distress
Fundamentals of Vaping-Associated Pulmonary Injury Leading to Severe Respiratory Distress Open
Vaping of flavored liquids has been touted as safe alternative to traditional cigarette smoking with decreased health risks. The popularity of vaping has dramatically increased over the last decade, particularly among teenagers who incorpo…
View article: VAPIng into ARDS: Acute Respiratory Distress Syndrome and Cardiopulmonary Failure
VAPIng into ARDS: Acute Respiratory Distress Syndrome and Cardiopulmonary Failure Open
"Modern" vaping involving battery-operated electronic devices began approximately one dozen years and has quickly evolved into a multibillion dollar industry providing products to an estimated 50 million users worldwide. Originally develop…
View article: Transcriptional features of biological age maintained in human cultured cardiac interstitial cells
Transcriptional features of biological age maintained in human cultured cardiac interstitial cells Open
Ex vivo expansion of cells is necessary in regenerative medicine to generate large populations for therapeutic use. Adaptation to culture conditions prompt an increase in transcriptome diversity and decreased population heterogeneity in cK…
View article: Editors’ Preamble to The Journal of Cardiovascular Aging
Editors’ Preamble to The Journal of Cardiovascular Aging Open
OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and schol…
View article: Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy
Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy Open
Cardiomyopathy is a leading cause of early mortality in Duchenne muscular dystrophy (DMD). There is a need to gain a better understanding of the molecular pathogenesis for the development effective therapies. Exosomes (exo) are secreted ve…
View article: PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression
PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression Open
Enhancing cardiomyocyte survival is crucial to blunt deterioration of myocardial structure and function following pathological damage. PIM1 (Proviral Insertion site in Murine leukemia virus (PIM) kinase 1) is a cardioprotective serine thre…
View article: Protocol for CardioCluster Creation
Protocol for CardioCluster Creation Open
Cellular therapy to treat heart failure is an ongoing focus of intense research, but with limited progress due to limitations in engraftment and persistence of injected cells. Engineered augmentation of established cellular effectors overc…
View article: Protocol for CardioCluster Creation
Protocol for CardioCluster Creation Open
Cellular therapy to treat heart failure is an ongoing focus of intense research, but with limited progress. Engineered augmentation of established cellular effectors overcomes impediments, enhancing reparative activity. Such ‘next generati…
View article: Blood speaks: Personalised medicine profiling for heart failure patients
Blood speaks: Personalised medicine profiling for heart failure patients Open
Heterogeneity in patient populations caused by factors such as age, genetic background, and clinical condition confound prognostication efforts toward treatment efficacy of coronary artery bypass grafting (CABG) surgery. The conundrum of p…
Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling Open
Aims Telomere attrition in cardiomyocytes is associated with decreased contractility, cellular senescence, and up-regulation of proapoptotic transcription factors. Pim1 is a cardioprotective kinase that antagonizes the aging phenotype of c…
View article: Atrial myxoma: the cardiac chameleon
Atrial myxoma: the cardiac chameleon Open
View article: Human CardioChimeras: Creation of a Novel “Next‐Generation” Cardiac Cell
Human CardioChimeras: Creation of a Novel “Next‐Generation” Cardiac Cell Open
Background CardioChimeras produced by fusion of murine c‐kit + cardiac interstitial cells with mesenchymal stem cells promote superior structural and functional recovery in a mouse model of myocardial infarction compared with either precur…
View article: Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit+ cardiac interstitial cells
Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit+ cardiac interstitial cells Open
Cardiac interstitial cells (CICs) perform essential roles in myocardial biology through preservation of homeostasis as well as response to injury or stress. Studies of murine CIC biology reveal remarkable plasticity in terms of transcripti…
View article: Cardiac tissue engineering therapeutic products to enhance myocardial contractility
Cardiac tissue engineering therapeutic products to enhance myocardial contractility Open
Researchers continue to develop therapeutic products for the repair and replacement of myocardial tissue that demonstrates contractility equivalent to normal physiologic states. As clinical trials focused on pure adult stem cell population…