Mark W. Sutherland
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View article: Identification of Long-Term Care Facility Residence From Admission Notes Using Large Language Models
Identification of Long-Term Care Facility Residence From Admission Notes Using Large Language Models Open
Importance An estimated half of all long-term care facility (LTCF) residents are colonized with antimicrobial-resistant organisms, and early identification of these patients on admission to acute care hospitals is a core strategy for preve…
View article: P-1490. Evaluating the Impact of Inadequate Empiric Gram-Negative Antibiotic Therapy on Clinical Outcomes
P-1490. Evaluating the Impact of Inadequate Empiric Gram-Negative Antibiotic Therapy on Clinical Outcomes Open
Background Many clinicians select broad-spectrum antibiotic therapy based on the concern that inadequate empiric coverage will be associated with a worse outcome. To explore this concern, we compared outcomes between patients started on em…
View article: P-1605. Matching the Right Test to the Right Patient: Building Probability-Based Decision Support into the Electronic Health Record to Guide Diagnosis of Community-Acquired Pneumonia (CAP) Among Hospitalized Patients
P-1605. Matching the Right Test to the Right Patient: Building Probability-Based Decision Support into the Electronic Health Record to Guide Diagnosis of Community-Acquired Pneumonia (CAP) Among Hospitalized Patients Open
Background Respiratory infections are among the most common reasons antibiotics are prescribed. However, 30-50% of patients started on antibiotics for CAP do not have bacterial infections. Methods We implemented clinical decision support (…
View article: Soil solarisation delivers near zero levels of Fusarium pseudograminearum in cereal crown rot reference sites
Soil solarisation delivers near zero levels of Fusarium pseudograminearum in cereal crown rot reference sites Open
The development of commercial varieties that are resistant or tolerant to crown rot caused by Fusarium species is an important goal for cereal breeding programs internationally. Ideally, this research requires experimental sites that are i…
View article: Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists
Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists Open
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
View article: Supplementary Table 2 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Table 2 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 52K, Lack of CYP1 induction by the chloromethylpyrroloindoline ICT2700
View article: Supplementary Figure 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Figure 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 120K, Representative CYP1A1 activity of the EJ138 bladder cell line and EJ138-1A1 bladder cell line, determined by measurement of Ethoxyresorufin O-de-ethylation
View article: Data from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Data from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
We identify cytochrome P450 1A1 (CYP1A1) as a target for tumor-selective drug development in bladder cancer and describe the characterization of ICT2700, designed to be metabolized from a prodrug to a potent cytotoxin selectively by CYP1A1…
View article: Supplementary Figure 2 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Figure 2 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 107K, In vivo metabolic profile of tumour and liver after administration of ICT2700 to CYP1A1 tumor-bearing mice
View article: Supplementary Table 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Table 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 85k, Expression of CYP1A1 protein in human transitional cell carcinoma (TCC) of the bladder by immunohistochemical analyses.
View article: Supplementary Methods from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Methods from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 109K, Methodology for analysis of CYP1 gene and protein expression,Detection of DNA-damage induced gamma-H2AX protein expression, and analysis of ICT2700 metabolism in mouse and human liver ex vivo
View article: Supplementary Table 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Table 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 85k, Expression of CYP1A1 protein in human transitional cell carcinoma (TCC) of the bladder by immunohistochemical analyses.
View article: Supplementary Figure 2 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Figure 2 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 107K, In vivo metabolic profile of tumour and liver after administration of ICT2700 to CYP1A1 tumor-bearing mice
View article: Supplementary Figure 3 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Figure 3 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 156K, Chromatogram of metabolite profile of ICT2700 incubated with human ex vivo liver microsomes demonstrating there is no evidence for the appearance of the cytotoxic metabolite ICT2740
View article: Supplementary Methods from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Methods from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 109K, Methodology for analysis of CYP1 gene and protein expression,Detection of DNA-damage induced gamma-H2AX protein expression, and analysis of ICT2700 metabolism in mouse and human liver ex vivo
View article: Supplementary Table 2 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Table 2 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 52K, Lack of CYP1 induction by the chloromethylpyrroloindoline ICT2700
View article: Supplementary Figure 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Figure 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 120K, Representative CYP1A1 activity of the EJ138 bladder cell line and EJ138-1A1 bladder cell line, determined by measurement of Ethoxyresorufin O-de-ethylation
View article: Supplementary Figure 3 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Supplementary Figure 3 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
PDF file - 156K, Chromatogram of metabolite profile of ICT2700 incubated with human ex vivo liver microsomes demonstrating there is no evidence for the appearance of the cytotoxic metabolite ICT2740
View article: Data from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Data from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder Open
We identify cytochrome P450 1A1 (CYP1A1) as a target for tumor-selective drug development in bladder cancer and describe the characterization of ICT2700, designed to be metabolized from a prodrug to a potent cytotoxin selectively by CYP1A1…
View article: AstriFlash A Flash-Based System for Online Services
AstriFlash A Flash-Based System for Online Services Open
Modern datacenters host datasets in DRAM to offer large-scale online services with tight tail-latency requirements. Unfortunately, as DRAM is expensive and increasingly difficult to scale, datacenter operators are forced to consider denser…
View article: Genetic Variability in West Timor Landrace Maize Populations
Genetic Variability in West Timor Landrace Maize Populations Open
Genetic variability information, which is a heritable difference among maize cultivars, is important to a long-term plant breeding program. In the last decade a number of researchers have studied the correlation between phenotypic and gene…
View article: New insights into the cellular mechanisms of plant growth at elevated atmospheric carbon dioxide concentrations
New insights into the cellular mechanisms of plant growth at elevated atmospheric carbon dioxide concentrations Open
Rising atmospheric carbon dioxide concentration ([CO 2 ]) significantly influences plant growth, development, and biomass. Increased photosynthesis rate, together with lower stomatal conductance, has been identified as the key factors that…
View article: Assessment of <i>Fusarium pseudograminearum</i> and <i>F. culmorum</i> Biomass in Seedlings of Potential Host Cereal Species
Assessment of <i>Fusarium pseudograminearum</i> and <i>F. culmorum</i> Biomass in Seedlings of Potential Host Cereal Species Open
Fusarium crown rot is a major disease of wheat and barley worldwide, with the most frequently isolated causal agents being Fusarium pseudograminearum and F. culmorum. This study has successfully designed a quantitative polymerase chain rea…
View article: Colonization of Durum Wheat (<i>Triticum turgidum</i> L. var. <i>durum</i>) Culms Exhibiting Premature Senescence (Dead Heads) Associated with <i>Fusarium pseudograminearum</i> Crown Rot
Colonization of Durum Wheat (<i>Triticum turgidum</i> L. var. <i>durum</i>) Culms Exhibiting Premature Senescence (Dead Heads) Associated with <i>Fusarium pseudograminearum</i> Crown Rot Open
Fusarium crown rot is a significant disease of durum wheat (Triticum turgidum L. var. durum), which exhibits high levels of disease susceptibility. The most extreme symptom of crown rot is a prematurely senescing culm that typically fails …
View article: Rare <i>Pyrenophora teres</i> Hybridization Events Revealed by Development of Sequence-Specific PCR Markers
Rare <i>Pyrenophora teres</i> Hybridization Events Revealed by Development of Sequence-Specific PCR Markers Open
Pyrenophora teres f. teres and P. teres f. maculata cause net form and spot form, respectively, of net blotch on barley (Hordeum vulgare). The two forms reproduce sexually, producing hybrids with genetic and pathogenic variability. Phenoty…
View article: Pentaploid Wheat Hybrids: Applications, Characterisation, and Challenges
Pentaploid Wheat Hybrids: Applications, Characterisation, and Challenges Open
Interspecific hybridisation between hexaploid and tetraploid wheat species leads to the development of F1 pentaploid hybrids with unique chromosomal constitutions. Pentaploid hybrids derived from bread wheat (Triticum aestivum L.) and duru…
View article: The crown rot ‘deadhead’ phenomenon in durum wheat
The crown rot ‘deadhead’ phenomenon in durum wheat Open
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\n[INTRODUCTION]
\nCrown rot of wheat, caused by Fusarium pseudograminearum (Fp), is a serious disease threat across the Australian wheat belt, particularly in durum wheat. Control of this disease is primarily based on crop rotations a…
View article: Urban Wake Field Generation Using LES for Application to Quadrotor Flight
Urban Wake Field Generation Using LES for Application to Quadrotor Flight Open
A method is presented for using LES to generate urban wake fields for use in studying their effects on autonomous quadrotor's flight performance. The flow field is generated around a single square building using OpenFOAM, and a MATLAB/Simu…