Mark T. Butt
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View article: HSV-1 infection as a rare trigger of methotrexate toxicity: A diagnostic and therapeutic challenge
HSV-1 infection as a rare trigger of methotrexate toxicity: A diagnostic and therapeutic challenge Open
Introduction: We present a novel case of severe pancytopenia in a 63-year-old woman receiving low-dose methotrexate for rheumatoid arthritis (RA), triggered by HSV-1 infection and refractory to leucovorin rescue. Dramatic reversal with cor…
View article: Myeloma mortality trends in the United States (Excluding Puerto Rico), 1999–2021, and future projections using ARIMA modeling and machine learning
Myeloma mortality trends in the United States (Excluding Puerto Rico), 1999–2021, and future projections using ARIMA modeling and machine learning Open
Myeloma, including multiple myeloma, is the most prevalent plasma cell neoplasm in the United States and represents a significant contributor to cancer-related morbidity and mortality. This study analyzes myeloma mortality trends and emplo…
View article: Adult‐plant resistance to net form net blotch in barley (<scp><i>Hordeum vulgare</i></scp> L.): Durability and genetic control
Adult‐plant resistance to net form net blotch in barley (<span><i>Hordeum vulgare</i></span> L.): Durability and genetic control Open
The research reported here was conducted to follow up on observations of durable adult‐plant resistance to net form net blotch in several Australian varieties of barley ( Hordeum vulgare L.). Over 11 years, isolates of Pyrenophora teres f.…
View article: Hyperspectral imaging detects biological stress of wheat for early diagnosis of crown rot disease
Hyperspectral imaging detects biological stress of wheat for early diagnosis of crown rot disease Open
Crown rot, caused by a stubble-soil fungal pathogen, threatens wheat production, leading to significant yield losses. The challenge lies in the absence of early visible symptoms for timely detection and management. While hyperspectral imag…
View article: Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis
Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis Open
Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at best, further it is known to have large inter-individual variability of serum conce…
View article: Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys
Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys Open
View article: Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: a potential new treatment route for amyotrophic lateral sclerosis
Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: a potential new treatment route for amyotrophic lateral sclerosis Open
Summary Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at best, further it is known to have large inter-individual variability of ser…
View article: The Use of Pathotype Data for the Selection and Development of Barley Lines with Useful Resistance to Scald
The Use of Pathotype Data for the Selection and Development of Barley Lines with Useful Resistance to Scald Open
Resistance in barley to scald caused by Rhynchosporium commune is readily overcome as virulent pathotypes in the pathogen population are selectively favoured over less virulent pathotypes. Diverse sources of resistance amongst host accessi…
View article: Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB
Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB Open
View article: Characterization of AAV-mediated dorsal root ganglionopathy
Characterization of AAV-mediated dorsal root ganglionopathy Open
View article: Application of Hyperspectral Imaging Technologies for Early Detection of Crown Rot Disease in Wheat Under Controlled Environment
Application of Hyperspectral Imaging Technologies for Early Detection of Crown Rot Disease in Wheat Under Controlled Environment Open
View article: Use of an animal model of disease for toxicology enables identification of a juvenile no observed adverse effect level for cyclocreatine in creatine transporter deficiency
Use of an animal model of disease for toxicology enables identification of a juvenile no observed adverse effect level for cyclocreatine in creatine transporter deficiency Open
In standard general toxicology studies in two species to support clinical development, cyclocreatine, a creatine analog for the treatment of creatine transporter deficiency, caused deaths, convulsions, and/or multi-organ pathology. The pot…
View article: Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency
Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency Open
View article: Sampling and Evaluating the Peripheral Nervous System
Sampling and Evaluating the Peripheral Nervous System Open
Many preclinical investigations limit the evaluation of the peripheral nervous system (PNS) to paraffin-embedded sections/hematoxylin and eosin–stained sections of the sciatic nerve. This limitation ignores several key mechanisms of toxici…
View article: International Regulatory Guiding Documents and Best Practice Recommendations on Peripheral Nervous System (PNS) Histopathologic Evaluation in Good Laboratory Practice (GLP)-Compliant Animal Toxicity Studies
International Regulatory Guiding Documents and Best Practice Recommendations on Peripheral Nervous System (PNS) Histopathologic Evaluation in Good Laboratory Practice (GLP)-Compliant Animal Toxicity Studies Open
Assessment of the peripheral nervous system (PNS) tissues during animal toxicity studies generally is included within guiding documents issued by regulatory agencies of individual nations (eg, US Environmental Protection Agency, US Food an…
View article: Autophagy of Sensory Neurons in the Trigeminal and Dorsal Root Ganglia of Cynomolgus Monkeys (<i>Macaca fascicularis</i>)
Autophagy of Sensory Neurons in the Trigeminal and Dorsal Root Ganglia of Cynomolgus Monkeys (<i>Macaca fascicularis</i>) Open
Although necrosis and apoptosis are uncommon, autophagy of sensory neurons (ASN) in trigeminal and dorsal root ganglia is a very common, spontaneous finding in cynomolgus monkeys ( Macaca fascicularis). Data from one author’s (Butt) labora…
View article: Effects of tanezumab on satellite glial cells in the cervicothoracic ganglion of cynomolgus monkeys: A 26-week toxicity study followed by an 8-week recovery period
Effects of tanezumab on satellite glial cells in the cervicothoracic ganglion of cynomolgus monkeys: A 26-week toxicity study followed by an 8-week recovery period Open
Tanezumab, a humanized monoclonal anti-NGF antibody, has demonstrated efficacy and safety profiles in Phase III clinical trials of chronic pain. In a 24-week study in non-human primates, morphological observations of sympathetic ganglia sh…
View article: Neurologic Medical Device Overview for Pathologists
Neurologic Medical Device Overview for Pathologists Open
Thorough morphologic evaluations of medical devices placed in or near the nervous system depend on many factors. Pathologists interpreting a neurologic device study must be familiar with the regulatory framework affecting device developmen…
View article: Toxicologic Pathology of the Peripheral Nervous System (PNS): Overview, Challenges, and Current Practices
Toxicologic Pathology of the Peripheral Nervous System (PNS): Overview, Challenges, and Current Practices Open
Peripheral nervous system (PNS) toxicity is a frequent adverse effect encountered in patients treated with certain therapeutics (e.g., antiretroviral drugs, cancer chemotherapeutics), in occupational workers exposed to industrial chemicals…
View article: From the Cover: Evaluation of the Effects of Tanezumab, a Monoclonal Antibody Against Nerve Growth Factor, on the Sympathetic Nervous System in Adult Cynomolgus Monkeys (Macaca fascicularis): A Stereologic, Histomorphologic, and Cardiofunctional Assessment
From the Cover: Evaluation of the Effects of Tanezumab, a Monoclonal Antibody Against Nerve Growth Factor, on the Sympathetic Nervous System in Adult Cynomolgus Monkeys (Macaca fascicularis): A Stereologic, Histomorphologic, and Cardiofunctional Assessment Open
Tanezumab, a humanized monoclonal antibody against nerve growth factor is in development for treatment of chronic pain. Three nonclinical studies assessed effects of clinically relevant and supratherapeutic doses of tanezumab on the sympat…
View article: Reveglucosidase alfa (BMN 701), an IGF2-Tagged rhAcid α-Glucosidase, Improves Respiratory Functional Parameters in a Murine Model of Pompe Disease
Reveglucosidase alfa (BMN 701), an IGF2-Tagged rhAcid α-Glucosidase, Improves Respiratory Functional Parameters in a Murine Model of Pompe Disease Open
View article: Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice
Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice Open
The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories and compared to the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)…
View article: Safety Evaluation of CNS Administered Biologics—Study Design, Data Interpretation, and Translation to the Clinic
Safety Evaluation of CNS Administered Biologics—Study Design, Data Interpretation, and Translation to the Clinic Open
Many central nervous system (CNS) diseases are inadequately treated by systemically administered therapies due to the blood brain barrier (BBB), which prevents achieving adequate drug concentrations at sites of action. Due to the increasin…
View article: Continuous intranigral infusion is not associated with observable behavioral deficits or marked pathology: a preclinical safety study
Continuous intranigral infusion is not associated with observable behavioral deficits or marked pathology: a preclinical safety study Open
OBJECTIVE A better understanding of the effects of chronically delivering compounds to the substantia nigra and nearby areas is important for the development of new therapeutic approaches to treat alpha-synucleinopathies, like Parkinson's …
View article: Scientific strategies necessary to resolve FDA clinical hold on anti-nerve growth factor inhibitors: The story of tanezumab
Scientific strategies necessary to resolve FDA clinical hold on anti-nerve growth factor inhibitors: The story of tanezumab Open
View article: Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice
Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice Open
Male and female C57BL/6J mice were administered diquat dibromide (DQ∙Br2) in their diets at concentrations of 0 (control), 12.5 and 62.5 ppm for 13 weeks to assess the potential effects of DQ on the nigrostriatal dopaminergic system. Achie…