Mark T. Hughes
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View article: Supplemental legend from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Supplemental legend from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
Supplemental legend
View article: Data from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Data from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
Purpose: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it.Expe…
View article: SI Table 1 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
SI Table 1 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
Top 10 correlated genes to BIM (BCL2L11)
View article: SI Table 2 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
SI Table 2 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
ZEB1 binding sites found in 1975R2 cells compared to 1975 parental cells
View article: SI Table 2 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
SI Table 2 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
ZEB1 binding sites found in 1975R2 cells compared to 1975 parental cells
View article: Data from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Data from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
Purpose: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it.Expe…
View article: SI Table 1 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
SI Table 1 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
Top 10 correlated genes to BIM (BCL2L11)
View article: Supplementary Figures 1-8 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Supplementary Figures 1-8 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
We have developed several models of EMT-mediated resistance to EGFR inhibitors in EGFR mutant lung cancers. Figure S1. Expression of EMT-related genes are inversely correlated with BCL2L11 expression; Figure S2. EMT induced by TGF-β res…
View article: Supplemental legend from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Supplemental legend from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
Supplemental legend
View article: Supplementary Figures 1-8 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Supplementary Figures 1-8 from Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
We have developed several models of EMT-mediated resistance to EGFR inhibitors in EGFR mutant lung cancers. Figure S1. Expression of EMT-related genes are inversely correlated with BCL2L11 expression; Figure S2. EMT induced by TGF-β res…
View article: “They Would Lift My Spirits”
“They Would Lift My Spirits” Open
Surrogate decision-makers make critical decisions for loved ones at the end of life, and some experience lasting negative psychological outcomes. Understanding whom they rely on for support and the types of support they value may inform nu…
View article: Emerging Experiences with Virtual Clinical Ethics Consultation: Case Studies from the United States and Malaysia
Emerging Experiences with Virtual Clinical Ethics Consultation: Case Studies from the United States and Malaysia Open
The COVID-19 pandemic has inspired numerous opportunities for telehealth implementation to meet diverse healthcare needs, including the use of virtual communication platforms to facilitate the growth of and access to clinical ethics consul…
View article: Ethics and Well-Being: The Health Professions and the COVID-19 Pandemic.
Ethics and Well-Being: The Health Professions and the COVID-19 Pandemic. Open
The COVID-19 pandemic has had a profound impact on health professionals, adding to the moral suffering and burnout that existed prepandemic. The physical, psychological, and moral toll of the pandemic has threatened the well-being and inte…
View article: The importance of offering vaccine choice in the fight against COVID-19
The importance of offering vaccine choice in the fight against COVID-19 Open
Prior research has shown that individuals' facial appearance can be indicative of their given names. The present study probes the origins of this face–name matching effect: whether names are given based on innate facial characteristics or …
View article: A Palliative Care Intervention for Patients on Phase 1 Studies
A Palliative Care Intervention for Patients on Phase 1 Studies Open
Background: Phase 1 clinical trials remain vital for oncology care. Patients on these trials require supportive care for quality-of-life (QOL) concerns. Objective: To test a Palliative Care Intervention (PCI) fo…
View article: Operational Recommendations for Scarce Resource Allocation in a Public Health Crisis
Operational Recommendations for Scarce Resource Allocation in a Public Health Crisis Open
View article: Health equity and distributive justice considerations in critical care resource allocation
Health equity and distributive justice considerations in critical care resource allocation Open
View article: From Modules to MOOCs: Application of the Six-Step Approach to Online Curriculum Development for Medical Education
From Modules to MOOCs: Application of the Six-Step Approach to Online Curriculum Development for Medical Education Open
Online curricula can make high-quality health professions education accessible in virtually any setting. They can enhance teaching and learning by both standardizing curricular resources and individualizing curricular experiences. Despite …
View article: Coamplification of <i>miR-4728</i> protects <i>HER2</i> -amplified breast cancers from targeted therapy
Coamplification of <i>miR-4728</i> protects <i>HER2</i> -amplified breast cancers from targeted therapy Open
Significance In HER2 -amplified breast cancers, HER2 inhibitors have been very successful as adjuvant therapy but not as monotherapy. Here, we demonstrate that coamplification of a HER2 intronic miRNA causes intrinsic resistance to HER2 in…
View article: Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM Open
Purpose: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it. Experimental …
View article: The Trial of Ascertaining Individual Preferences for Loved Ones' Role in End-of-Life Decisions (TAILORED) Study: A Randomized Controlled Trial to Improve Surrogate Decision Making
The Trial of Ascertaining Individual Preferences for Loved Ones' Role in End-of-Life Decisions (TAILORED) Study: A Randomized Controlled Trial to Improve Surrogate Decision Making Open
View article: Characteristics of Participants Enrolled onto a Randomized Controlled Trial of Palliative Care for Patients on Phase I Studies
Characteristics of Participants Enrolled onto a Randomized Controlled Trial of Palliative Care for Patients on Phase I Studies Open
Phase 1 clinical trial participants experience unmet QOL needs at baseline and levels of distress that merit clinical intervention. Although this study is in progress, initial findings support the potential benefits of PC among this popula…
View article: Corrigendum
Corrigendum Open
View article: Patient and caregiver characteristics related to completion of advance directives in terminally ill patients
Patient and caregiver characteristics related to completion of advance directives in terminally ill patients Open
Objective: There is a growing body of literature describing the characteristics of patients who plan for the end of life, but little research has examined how caregivers influence patients' advance care planning (ACP). The purpose of this …
View article: Decision-Making of Patients With Implantable Cardioverter-Defibrillators at End of Life: Family Members’ Experiences
Decision-Making of Patients With Implantable Cardioverter-Defibrillators at End of Life: Family Members’ Experiences Open
Introduction: Many patients with advanced heart failure (HF) experience the life-extending benefits of implantable cardioverter-defibrillators (ICD), but at the end stage of HF, patients may experience shocks with increasing frequency and …
View article: Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination
Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination Open
Fewer than half of children with high-risk neuroblastoma survive. Many of these tumors harbor high-level amplification of MYCN, which correlates with poor disease outcome. Using data from our large drug screen we predicted, and subsequentl…
View article: Symptom frequency, severity, and quality of life among persons with three disease trajectories: cancer, ALS, and CHF
Symptom frequency, severity, and quality of life among persons with three disease trajectories: cancer, ALS, and CHF Open