Mark Nelson
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Author Swipe
View article: Potassium-enriched salt for patients with hypertension: a Hypertension Australia and National Hypertension Taskforce of Australia Position Statement
Potassium-enriched salt for patients with hypertension: a Hypertension Australia and National Hypertension Taskforce of Australia Position Statement Open
Introduction: High blood pressure remains the leading risk factor for cardiovascular and all-cause deaths in Australia. Higher sodium and lower potassium intake are well established risk factors for elevated blood pressure and increased ca…
View article: Co‐Design of a Registry‐Based Tailored Follow‐up Service Intervention for People Living With Stroke: A Multiple Method Consensus Approach
Co‐Design of a Registry‐Based Tailored Follow‐up Service Intervention for People Living With Stroke: A Multiple Method Consensus Approach Open
Background Often people experience ongoing health challenges after stroke. The Australian Stroke Clinical Registry collects patient‐reported outcomes after stroke. Many patients report challenges that are potentially addressable through ad…
View article: Development of a Health Text Message System to Support Stroke Prevention: A Component of the Love Your Brain Digital Platform
Development of a Health Text Message System to Support Stroke Prevention: A Component of the Love Your Brain Digital Platform Open
Objectives Globally, stroke is a common cause of death and disability. More than 80% of strokes are reported to be preventable through effective management of modifiable risk factors. Text messages can encourage changes in health behaviour…
View article: Evaluation of a digital health platform for preventing stroke in the Australian community: Study protocol for a randomized controlled trial – Love Your Brain
Evaluation of a digital health platform for preventing stroke in the Australian community: Study protocol for a randomized controlled trial – Love Your Brain Open
Rationale One in four people will have a stroke in their lifetime. Over 80% of strokes are preventable through the management of modifiable risk factors. There is a growing demand from the community for information about how to prevent str…
View article: Aspirin and healthy lifespan in older people: main outcome of the ASPREE-XT observational study
Aspirin and healthy lifespan in older people: main outcome of the ASPREE-XT observational study Open
National Institute on Aging and the National Cancer Institute (USA).
View article: The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial
The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial Open
Background Chronic low-grade inflammation is hypothesised as a central driver of frailty. This study aims to evaluate whether low-dose aspirin can reverse frailty status among initially prefrail/frail older adults. Methods This was a post …
View article: General Practitioner Coordinated Multidisciplinary Care Improves Long-Term Survival following Stroke with Variation by Impairment
General Practitioner Coordinated Multidisciplinary Care Improves Long-Term Survival following Stroke with Variation by Impairment Open
Background: Australian Medicare funded policies to support General Practtitioners (GPs) to coordinate multidisciplinary care (MDC) with other healthcare providers have potential to benefit survivors of stroke/transient ischaemic attack (TI…
View article: Moderate Alcohol Consumption and Risk of Depression: A Longitudinal Analysis in Community-Dwelling Older Adults
Moderate Alcohol Consumption and Risk of Depression: A Longitudinal Analysis in Community-Dwelling Older Adults Open
Background/Objectives: Evidence suggests a J-shaped association between alcohol consumption and depression, but it remains unclear whether this reflects a true causal effect, reverse causation, or methodological bias. This uncertainty is p…
View article: Genetic Variants, Metabolic Dysfunction-Associated Fatty Liver Disease, and Major Health Outcomes in Older Adults
Genetic Variants, Metabolic Dysfunction-Associated Fatty Liver Disease, and Major Health Outcomes in Older Adults Open
Background and Aims: Multiple genetic variants have been associated with disease prevalence and outcomes in middle-aged people with metabolic dysfunction-associated fatty liver disease (MAFLD). However, genetic studies in older adults have…
View article: Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial
Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial Open
Background and Aims Guidelines recommend against routine initiation of low-dose aspirin in older adults for primary prevention of atherosclerotic cardiovascular disease events. This study aimed to estimate long-term and post-trial effects …
View article: From the ASPREE investigators: Response to Wittes et al.
From the ASPREE investigators: Response to Wittes et al. Open
View article: Prevalence and outcomes of steatotic liver disease subtypes in older adults
Prevalence and outcomes of steatotic liver disease subtypes in older adults Open
Background: Steatotic liver disease (SLD) is a significant cause of chronic liver disease. However, the relative prevalence and prognostic significance of various disease entities according to recently defined classification systems (MAFLD…
View article: STAREE-HEART: A randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants
STAREE-HEART: A randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants Open
clinicaltrials.gov. Unique identifier: NCT04536870.
View article: Processes Underpinning Successful Co‐Design: Lessons From a Digital Health Project
Processes Underpinning Successful Co‐Design: Lessons From a Digital Health Project Open
Background Co‐design helps to align research with end‐user needs, but there is no consistent method for reporting co‐design methodology and evaluation. We share our experiences co‐designing the Love Your Brain digital platform for stroke p…
View article: Co‐Designing a Digital Stroke Prevention Platform: Leveraging Lived Experience and Expert Advice
Co‐Designing a Digital Stroke Prevention Platform: Leveraging Lived Experience and Expert Advice Open
Background The majority of strokes are preventable through effective risk factor management. Existing primary prevention strategies have insufficient reach and effectiveness. Digital health technologies offer the potential to overcome some…
View article: Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians
Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians Open
Objective To examine the prevalence of health risk factors by rurality status and the association of rurality and incidence of disability‐free survival (DFS), its components (death, dementia and physical disability), cardiovascular disease…
View article: Review of strategies to improve adherence to lipid-lowering therapy in the primary prevention of cardiovascular disease
Review of strategies to improve adherence to lipid-lowering therapy in the primary prevention of cardiovascular disease Open
Poor adherence to lipid-lowering therapy (LLT) is a major barrier in the prevention of cardiovascular disease (CVD) worldwide. The burden of CVD can be significantly reduced by LLT, particularly in populations with high cardiovascular (CV)…
View article: Framingham Risk Score Prediction at 12 Months in the STANDFIRM Randomized Control Trial
Framingham Risk Score Prediction at 12 Months in the STANDFIRM Randomized Control Trial Open
Background The STANDFIRM (Shared Team Approach Between Nurses and Doctors for Improved Risk Factor Management; ANZCTR registration ACTRN12608000166370) trial was designed to test the effectiveness of chronic disease care management for mod…
View article: How and why do Australians obtain blood pressure devices for use at home? A mixed-methods study
How and why do Australians obtain blood pressure devices for use at home? A mixed-methods study Open
Background Only 10-20% of blood pressure (BP) devices available are validated. Little is known about how and why patients choose BP devices for home BP measurement (HBPM), which was the aim of this study. Methods Mixed-methods study (onlin…
View article: A randomised clinical trial of STAtin therapy for Reducing Events in the Elderly (STAREE): Statistical analysis plan
A randomised clinical trial of STAtin therapy for Reducing Events in the Elderly (STAREE): Statistical analysis plan Open
The STAREE randomised controlled trial of 9971 community-dwelling older adults without cardiovascular disease, diabetes or dementia is designed to compare daily 40mg atorvastatin to placebo. We present a statistical analysis plan to pre-sp…
View article: Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults
Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults Open
Tracking variability of TC and LDL-c may serve as a novel biomarker of incident dementia and cognitive decline in older adults.
View article: Evaluation of health-related quality of life changes in an Australian rapid access chest pain clinic
Evaluation of health-related quality of life changes in an Australian rapid access chest pain clinic Open
View article: Preventing Stroke Research Priorities Project: An Initiative of Synergies to Prevent Stroke (STOPstroke)
Preventing Stroke Research Priorities Project: An Initiative of Synergies to Prevent Stroke (STOPstroke) Open
Background: Research priority setting projects provide a method to engage stakeholders in the prioritisation of research activities. We conducted a priority setting project to identify priorities for research into the primary and secondary…
View article: PISTACHIO (Primary Trauma Care Course Impact & Outcome): A Prospective Before and after Intervention Study of the Primary Trauma Care Course Effect on Road Trauma Morbidity and Mortality in Two Vietnamese Hospitals
PISTACHIO (Primary Trauma Care Course Impact & Outcome): A Prospective Before and after Intervention Study of the Primary Trauma Care Course Effect on Road Trauma Morbidity and Mortality in Two Vietnamese Hospitals Open
View article: Quality indicators for the primary prevention of cardiovascular disease in primary care: A systematic review
Quality indicators for the primary prevention of cardiovascular disease in primary care: A systematic review Open
Background Primary care is usually the entry point for preventing cardiovascular disease (CVD). Quality indicators can be used to assess and monitor the quality of care provided in a primary care setting. In this systematic review, we aime…
View article: Associations between MASLD, atrial fibrillation, cardiovascular events, mortality and aspirin use in older adults
Associations between MASLD, atrial fibrillation, cardiovascular events, mortality and aspirin use in older adults Open
View article: Age-Related Hearing Loss: A Cross-Sectional Study of Healthy Older Australians
Age-Related Hearing Loss: A Cross-Sectional Study of Healthy Older Australians Open
Introduction: Hearing loss is common in ageing populations, but thorough investigation of factors associated with objective hearing loss in otherwise healthy, community-dwelling older individuals is rare. We examined prevalence of age-rela…
View article: Management of people after stroke in 383 Victorian general practices, 2014–2018: analysis of linked stroke registry and general practice data
Management of people after stroke in 383 Victorian general practices, 2014–2018: analysis of linked stroke registry and general practice data Open
Objective To evaluate the management in Victorian general practice of people who have been hospitalised with stroke or transient ischaemic attacks (TIA). Study design Retrospective observational study; analysis of linked Australian Stroke …
View article: Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People
Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People Open
Background The risk–benefit balance of statin use in healthy older people is uncertain. We describe the baseline characteristics of the STAREE (Statins in Reducing Events in the Elderly) trial, which is a randomized, double‐blind, placebo‐…
View article: Antihypertensive medications and dementia in older adults with hypertension
Antihypertensive medications and dementia in older adults with hypertension Open
Background Studies on middle-aged or individuals with cognitive or cardiovascular impairments, have established that intensive blood pressure (BP) control reduces cognitive decline risk. However, uncertainty exists on differential effects …