Mark Trifiro
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View article: Performance and functional assessment of the Kimera P-IV point-of-care plasmonic qPCR prototype for ultra rapid pathogen detection of <i>chlamydia trachomatis</i>
Performance and functional assessment of the Kimera P-IV point-of-care plasmonic qPCR prototype for ultra rapid pathogen detection of <i>chlamydia trachomatis</i> Open
Current standard microbiological techniques are generally very time consuming, usually requiring 24–72 h to establish a diagnosis. Consequentially, contemporary clinical practices implement broad-spectrum antibiotic administration prior to…
View article: 8599 Development of an androgen receptor transgenic mouse that displays the complete attributes of Metabolic Syndrome
8599 Development of an androgen receptor transgenic mouse that displays the complete attributes of Metabolic Syndrome Open
Disclosure: C. Alvarado: None. L.K. Beitel: None. M. Paliouras: None. M.A. Trifiro: None. The mouse androgen receptor (AR) shares over 90% homology with the human ortholog, but it lacks the CAG encoded poly-Q tract; instead, it contains a …
View article: Assessing Different PCR Master Mixes for Ultrarapid DNA Amplification: Important Analytical Parameters
Assessing Different PCR Master Mixes for Ultrarapid DNA Amplification: Important Analytical Parameters Open
The basic principles of ultrafast plasmonic PCR have been promulgated in the scientific and technological literature for over a decade. Yet, its everyday diagnostic utility remains unvalidated in pre-clinical and clinical settings. Althoug…
View article: Enhancing in vitro photothermal therapy using plasmonic gold nanorod decorated multiwalled carbon nanotubes
Enhancing in vitro photothermal therapy using plasmonic gold nanorod decorated multiwalled carbon nanotubes Open
Photothermal therapy (PTT) is a promising approach for cancer treatment that selectively heats malignant cells while sparing healthy cells. Here, the light-to-heat conversion efficiency of multiwalled carbon nanotubes (MWCNTs) within the n…
View article: Photothermal therapy of papillary thyroid cancer tumor xenografts with targeted thyroid stimulating hormone receptor antibody functionalized multiwalled carbon nanotubes
Photothermal therapy of papillary thyroid cancer tumor xenografts with targeted thyroid stimulating hormone receptor antibody functionalized multiwalled carbon nanotubes Open
Multiwalled carbon nanotubes (MWCNTs) are being widely investigated in multiple biomedical applications including, and not limited to, drug delivery, gene therapy, imaging, biosensing, and tissue engineering. Their large surface area and a…
View article: Functionalized Carbon Nanoparticles as Theranostic Agents and Their Future Clinical Utility in Oncology
Functionalized Carbon Nanoparticles as Theranostic Agents and Their Future Clinical Utility in Oncology Open
Over the years, research of nanoparticle applications in pre-clinical and clinical applications has greatly advanced our therapeutic and imaging approaches to many diseases, most notably neoplastic disorders. In particular, the innate prop…
View article: Investigation of androgen receptor-dependent alternative splicing has identified a unique subtype of lethal prostate cancer
Investigation of androgen receptor-dependent alternative splicing has identified a unique subtype of lethal prostate cancer Open
A complete proteomics study characterizing active androgen receptor (AR) complexes in prostate cancer (PCa) cells identified a diversity of protein interactors with tumorigenic annotations, including known RNA splicing factors. Thus, we ch…
View article: Model-based Analysis for Real-time Label-free Ultraviolet Quantification of Ultrafast Plasmonic Polymerase Chain Reaction
Model-based Analysis for Real-time Label-free Ultraviolet Quantification of Ultrafast Plasmonic Polymerase Chain Reaction Open
A mathematical model for DNA quantification was calibrated using experimental results from real-time 260nm absorption measurements of plasmonic PCR thermocycling. The effect of different PCR parameters on template amplification was investi…
View article: Genome-wide analysis of androgen receptor binding and transcriptomic analysis in mesenchymal subsets during prostate development
Genome-wide analysis of androgen receptor binding and transcriptomic analysis in mesenchymal subsets during prostate development Open
Prostate development is controlled by androgens, the androgen receptor (AR) and mesenchymal–epithelial signalling. We used chromatin immunoprecipitation sequencing (ChIP-seq) to define AR genomic binding in the male and female mesenchyme. …
View article: A Targeted Bivalent Androgen Receptor Binding Compound for Prostate Cancer Therapy
A Targeted Bivalent Androgen Receptor Binding Compound for Prostate Cancer Therapy Open
View article: New insights into the role of intra-tumor genetic heterogeneity in carcinogenesis: identification of complex single gene variance within tumors
New insights into the role of intra-tumor genetic heterogeneity in carcinogenesis: identification of complex single gene variance within tumors Open
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis and treatment, including the occurrence, development, progression, metastasis, and treatment of oncologic disease. It covers basic, trans…
View article: Network Analysis Reveals a Signaling Regulatory Loop in the <i>PIK3CA</i>-Mutated Breast Cancer Predicting Survival Outcome
Network Analysis Reveals a Signaling Regulatory Loop in the <i>PIK3CA</i>-Mutated Breast Cancer Predicting Survival Outcome Open
Mutated genes are rarely common even in the same pathological type between cancer patients and as such, it has been very challenging to interpret genome sequencing data and difficult to predict clinical outcomes. PIK3CA is one of a few gen…
View article: Prostate-specific membrane antigen–directed nanoparticle targeting for extreme nearfield ablation of prostate cancer cells
Prostate-specific membrane antigen–directed nanoparticle targeting for extreme nearfield ablation of prostate cancer cells Open
Almost all biological therapeutic interventions cannot overcome neoplastic heterogeneity. Physical ablation therapy is immune to tumor heterogeneity, but nearby tissue damage is the limiting factor in delivering lethal doses. Multi-walled …
View article: Redefining Androgen Receptor Function: Clinical Implications in Understanding Prostate Cancer Progression and Therapeutic Resistance
Redefining Androgen Receptor Function: Clinical Implications in Understanding Prostate Cancer Progression and Therapeutic Resistance Open
The current description of the function of the human androgen receptor (AR), as a transcription factor directing androgen responsive gene expression, is limited in scope and thus is unable to account for the varied cellular and physiologic…
View article: Correction: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells
Correction: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells Open
[This corrects the article DOI: 10.1371/journal.pone.0149723.].
View article: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells
Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells Open
A BioNanofluid platform offering a potential therapeutic path for papillary thyroid cancer has been investigated, with our in vitro results suggesting the development of a potent and rapid method of selective cancer cell killing. Therefore…