Mark W. Feinberg
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View article: The Non-Coding RNA Journal Club: Highlights on Recent Papers—14
The Non-Coding RNA Journal Club: Highlights on Recent Papers—14 Open
The field of non-coding RNA research is advancing at a breathtaking pace, continually uncovering new layers of regulatory complexity and functional diversity [...]
View article: A smooth muscle cell lncRNA controls angiogenesis in chronic limb-threatening ischemia through miR-143-3p/HHIP signaling
A smooth muscle cell lncRNA controls angiogenesis in chronic limb-threatening ischemia through miR-143-3p/HHIP signaling Open
Peripheral artery disease (PAD) often advances to chronic limb-threatening ischemia (CLTI), resulting in severe complications such as limb amputation. Despite the potential of therapeutic angiogenesis, the mechanisms of cell-cell communica…
View article: Endothelial-Enriched lncRNA Gm39822 Modulates Inflammation and Dysfunction in Non-Diabetic Endothelial Cells
Endothelial-Enriched lncRNA Gm39822 Modulates Inflammation and Dysfunction in Non-Diabetic Endothelial Cells Open
Endothelial dysfunction underlies several vascular complications, including diabetes and atherosclerosis. However, the underlying role of long non-coding RNAs (lncRNAs) remains poorly understood. This study elucidated the role of lncRNA Gm…
View article: TEAD1‐Mediated Trans‐Differentiation of Vascular Smooth Muscle Cells into Fibroblast‐Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques
TEAD1‐Mediated Trans‐Differentiation of Vascular Smooth Muscle Cells into Fibroblast‐Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques Open
Atherosclerotic plaque rupture mainly contributes to acute coronary syndrome (ACS). Insufficient repair of these plaques leads to thrombosis and subsequent ACS. Central to this process is the modulation of vascular smooth muscle cells (VSM…
View article: FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy
FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy Open
Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) …
View article: Synergistic effect of Hypoxic Conditioning and Cell‐Tethering Colloidal Gels enhanced Productivity of MSC Paracrine Factors and Accelerated Vessel Regeneration
Synergistic effect of Hypoxic Conditioning and Cell‐Tethering Colloidal Gels enhanced Productivity of MSC Paracrine Factors and Accelerated Vessel Regeneration Open
Microporous hydrogels have been widely used for delivering therapeutic cells. However, several critical issues, such as the lack of control over the harsh environment they are subjected to under pathological conditions and rapid egression …
View article: Injectable Self‐Oxygenating Cardio‐Protective and Tissue Adhesive Silk‐Based Hydrogel for Alleviating Ischemia After Mi Injury (Small 32/2024)
Injectable Self‐Oxygenating Cardio‐Protective and Tissue Adhesive Silk‐Based Hydrogel for Alleviating Ischemia After Mi Injury (Small 32/2024) Open
Silk-Based Hydrogels In article number 2312261, Su Ryon Shin and co-workers present that the local delivery of oxygen and a chemoattractant of stem cells via injectable, mechanically robust, and tissue-adhesive silk-based hybrid hydrogels …
View article: miR-369-3p ameliorates diabetes-associated atherosclerosis by regulating macrophage succinate-GPR91 signalling
miR-369-3p ameliorates diabetes-associated atherosclerosis by regulating macrophage succinate-GPR91 signalling Open
Aims Diabetes leads to dysregulated macrophage immunometabolism, contributing to accelerated atherosclerosis progression. Identifying critical factors to restore metabolic alterations and promote resolution of inflammation remains an unmet…
View article: Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis
Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis Open
Diabetes-associated atherosclerosis involves excessive immune cell recruitment and plaque formation. However, the mechanisms remain poorly understood. Transcriptomic analysis of the aortic intima in Ldlr-/- mice on a high-fat, h…
View article: Can removal of zombie cells revitalize the aging cardiovascular system?
Can removal of zombie cells revitalize the aging cardiovascular system? Open
View article: Therapeutic Delivery of MICRORNA-369-3p Promotes Atherosclerosis Regression in Diabetic Mice by Regulating Bone Marrow Myeloid Progenitors
Therapeutic Delivery of MICRORNA-369-3p Promotes Atherosclerosis Regression in Diabetic Mice by Regulating Bone Marrow Myeloid Progenitors Open
View article: The Non-Coding RNA Journal Club: Highlights on Recent Papers—13
The Non-Coding RNA Journal Club: Highlights on Recent Papers—13 Open
We are delighted to share with you our thirteenth Journal Club and highlight some of the most interesting papers published recently [...]
View article: FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis—Brief Report
FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis—Brief Report Open
BACKGROUND: BETs (bromodomain and extraterminal domain–containing epigenetic reader proteins), including BRD4 (bromodomain-containing protein 4), orchestrate transcriptional programs induced by pathogenic stimuli, as intensively studied in…
View article: Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 Inhibition in Patients With Type 2 Diabetes
Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 Inhibition in Patients With Type 2 Diabetes Open
OBJECTIVE To develop a risk assessment tool to identify patients with type 2 diabetes (T2D) at higher risk for kidney disease progression and who might benefit more from sodium–glucose cotransporter 2 (SGLT2) inhibition. RESEARCH DESIGN AN…
View article: <strong>Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 inhibition in Patients with Type 2 Diabetes</strong>
<strong>Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 inhibition in Patients with Type 2 Diabetes</strong> Open
Objective: To develop a risk assessment tool to identify patients with T2D at higher risk for kidney disease progression and who might benefit most from SGLT2 inhibition. Research Design and Methods: 41,…
View article: <strong>Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 inhibition in Patients with Type 2 Diabetes</strong>
<strong>Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 inhibition in Patients with Type 2 Diabetes</strong> Open
Objective: To develop a risk assessment tool to identify patients with T2D at higher risk for kidney disease progression and who might benefit most from SGLT2 inhibition. Research Design and Methods: 41,…
View article: Electrostatically assembled wound dressings deliver pro-angiogenic anti-miRs preferentially to endothelial cells
Electrostatically assembled wound dressings deliver pro-angiogenic anti-miRs preferentially to endothelial cells Open
View article: Assessment of Atherothrombotic Risk in Patients With Type 2 Diabetes Mellitus
Assessment of Atherothrombotic Risk in Patients With Type 2 Diabetes Mellitus Open
View article: Trends of Concomitant Diabetes and Peripheral Artery Disease and Lower Extremity Amputation in US Medicare Patients, 2007 to 2019
Trends of Concomitant Diabetes and Peripheral Artery Disease and Lower Extremity Amputation in US Medicare Patients, 2007 to 2019 Open
Background: Previous studies demonstrate geographic and racial/ethnic variation in diagnosis and complications of diabetes and peripheral artery disease (PAD). However, recent trends for patients diagnosed with both PAD and diabetes are la…
View article: Deficiency of miR-409-3p improves myocardial neovascularization and function through modulation of DNAJB9/p38 MAPK signaling
Deficiency of miR-409-3p improves myocardial neovascularization and function through modulation of DNAJB9/p38 MAPK signaling Open
Angiogenesis is critical for tissue repair following myocardial infarction (MI), which is exacerbated under insulin resistance or diabetes. MicroRNAs are regulators of angiogenesis. We examined the metabolic regulation of miR-409-3p in pos…
View article: Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis
Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis Open
Patients with peripheral artery disease (PAD) and diabetes compose a high-risk population for development of critical limb ischemia (CLI) and amputation, although the underlying mechanisms remain poorly understood. Comparison of dysregulat…
View article: A miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia
A miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia Open
Patients with peripheral artery disease (PAD) and diabetes have the highest risk of critical limb ischemia (CLI) and amputation, yet the underlying mechanisms remain incompletely understood. MicroRNA (miRNA) sequencing of plasma from diabe…
View article: High-sensitivity cardiac troponin T is associated with disease activity in patients with inflammatory arthritis
High-sensitivity cardiac troponin T is associated with disease activity in patients with inflammatory arthritis Open
Objective To investigate whether high-sensitivity cardiac troponin T (hsTnT) correlates to markers of disease activity in inflammatory arthritis (IA), and whether antirheumatic treatment influences hsTnT levels. Methods We assessed 115 pat…
View article: Macrophage-Specific NLRC5 Protects From Cardiac Remodeling Through Interaction With HSPA8
Macrophage-Specific NLRC5 Protects From Cardiac Remodeling Through Interaction With HSPA8 Open
View article: Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis
Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis Open
View article: Using a cohort study of diabetes and peripheral artery disease to compare logistic regression and machine learning via random forest modeling
Using a cohort study of diabetes and peripheral artery disease to compare logistic regression and machine learning via random forest modeling Open
Background This study illustrates the use of logistic regression and machine learning methods, specifically random forest models, in health services research by analyzing outcomes for a cohort of patients with concomitant peripheral artery…
View article: Dysregulated Genes, MicroRNAs, Biological Pathways, and Gastrocnemius Muscle Fiber Types Associated With Progression of Peripheral Artery Disease: A Preliminary Analysis
Dysregulated Genes, MicroRNAs, Biological Pathways, and Gastrocnemius Muscle Fiber Types Associated With Progression of Peripheral Artery Disease: A Preliminary Analysis Open
Background Peripheral artery disease (PAD) is associated with gastrocnemius muscle abnormalities. However, the biological pathways associated with gastrocnemius muscle dysfunction and their associations with progression of PAD are largely …
View article: Deriving International Classification of Diseases, 9th and 10th revision, codes for identifying and following up patients with diabetic lower extremity ulcers
Deriving International Classification of Diseases, 9th and 10th revision, codes for identifying and following up patients with diabetic lower extremity ulcers Open
We identified 45 ICD-9 and 304 ICD-10 ulcer codes, which identified patients at risk of amputation from diabetes and peripheral artery disease. Although further validation at the medical record level is required, these codes can be used fo…
View article: MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia
MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia Open
View article: miR‐181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway
miR‐181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway Open
Endothelial cell (EC) aging plays a vital role in the pathogenesis of cardiovascular disease (CVD). MicroRNAs have emerged as crucial regulators of target gene expression by inhibiting mRNA translation and/or promoting mRNA degradation. We…