Mark W. Hamrick
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View article: GMP‐Compliant Process for the Manufacturing of an Extracellular Vesicles‐Enriched Secretome Product Derived From Cardiovascular Progenitor Cells Suitable for a Phase I Clinical Trial
GMP‐Compliant Process for the Manufacturing of an Extracellular Vesicles‐Enriched Secretome Product Derived From Cardiovascular Progenitor Cells Suitable for a Phase I Clinical Trial Open
Extracellular vesicle (EV)‐enriched secretomes are emerging as a new and innovative therapeutic option in the field of regenerative medicine. The clinical use of EV‐enriched secretome‐based products requires manufacturing processes and qua…
View article: Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions Open
The aryl hydrocarbon receptor (AhR) is proposed to mediate the frailty-promoting effects of the tryptophan metabolite kynurenine, which increases with age in mice and humans. The goal of the current study was to test whether administration…
View article: The Effects of Six Months of Exercise on Single- and Dual-Task Posture, Gait, and Functional Mobility Relative to Usual Care Alone Among People Living with Dementia: The ENABLED Pilot Randomized Controlled Trial
The Effects of Six Months of Exercise on Single- and Dual-Task Posture, Gait, and Functional Mobility Relative to Usual Care Alone Among People Living with Dementia: The ENABLED Pilot Randomized Controlled Trial Open
Cognitive–motor integration is the coordination of cognitive and motor processes; it is commonly impaired among people living with dementia (PWD) and may be improved through exercise. This pilot randomized controlled trial (1:1) aimed to d…
View article: Expression of the aryl hydrocarbon receptor in Osterix-lineage cells regulates adult skeletal homeostasis in a compartment-specific manner
Expression of the aryl hydrocarbon receptor in Osterix-lineage cells regulates adult skeletal homeostasis in a compartment-specific manner Open
Kynurenine (KYN), a tryptophan metabolite that increases with age, impairs osteoblast function. The aryl hydrocarbon receptor (AhR) has been proposed to mediate KYN’s actions in bone. To test whether deletion of AhR in osteoblasts is benef…
View article: The impact of the 6‐month adapted Otago Exercise Program on clinical measures of physical function relative to usual care alone in people living with dementia in residential care facilities: A pilot randomized controlled trial
The impact of the 6‐month adapted Otago Exercise Program on clinical measures of physical function relative to usual care alone in people living with dementia in residential care facilities: A pilot randomized controlled trial Open
Background Dementia compromises physical function, posing risks for falls. People living with dementia (PWD) have been historically excluded from intervention trials due to researchers’ eligibility criteria. Exercise shows potential in enh…
View article: The effects of six months of exercise on single‐ and dual‐task gait and functional mobility relative to usual care alone among people living with dementia: A pilot randomized controlled trial
The effects of six months of exercise on single‐ and dual‐task gait and functional mobility relative to usual care alone among people living with dementia: A pilot randomized controlled trial Open
Background Exercise may improve dual‐tasking and mobility impairments among people living with dementia (PWD), but more evidence is needed. The purpose of this pilot randomized controlled trial (RCT) was to determine the effect of six mont…
View article: Exercising Physiological Pathways: The Impact of Exercise on Metabolic Aging, Cellular Aging, and Inflammatory Biomarkers in All‐Cause Dementia
Exercising Physiological Pathways: The Impact of Exercise on Metabolic Aging, Cellular Aging, and Inflammatory Biomarkers in All‐Cause Dementia Open
Background Physiological changes, including metabolic and cellular aging, as well as increased inflammation, occur in people living with dementia (PWD). While there is existing evidence in other populations suggesting that exercise may imp…
View article: The relationship between physiological biomarkers, physical function, and fall‐risk among people living with dementia
The relationship between physiological biomarkers, physical function, and fall‐risk among people living with dementia Open
Background People living with dementia (PWD) have upregulated inflammatory pathways, exaggerated metabolic aging, and cellular aging. They also have declines in physical function and heightened fall‐risk. Understanding the physiologic fact…
View article: Does six months of structured group exercise improve physical activity, sedentary behavior, and sleep in people living with dementia? A pilot randomized controlled trial
Does six months of structured group exercise improve physical activity, sedentary behavior, and sleep in people living with dementia? A pilot randomized controlled trial Open
Background People living with dementia (PWD) often have inactivity‐induced muscle atrophy, increased sedentary behavior, and circadian rhythm disorders. Exercise may improve physical activity, sedentary behavior, and sleep in PWD, but furt…
View article: THE AHR AS A POTENTIAL MEDIATOR OF MUSCULOSKELETAL FRAILTY WITH ANTI-RETROVIRAL THERAPY
THE AHR AS A POTENTIAL MEDIATOR OF MUSCULOSKELETAL FRAILTY WITH ANTI-RETROVIRAL THERAPY Open
Musculoskeletal frailty, often associated with aging, is frequently observed in patients living with HIV on long term anti-retroviral therapy (ART) and linked to poor health outcomes from accelerated disease progression to increased mortal…
View article: Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation
Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation Open
A sharp drop in lenticular glutathione (GSH) plays a pivotal role in age-related cataract (ARC) formation. Despite recognizing GSH’s importance in lens defense for decades, its decline with age remains puzzling. Our recent study revealed a…
View article: The Impact of Dual-Tasks and Disease Severity on Posture, Gait, and Functional Mobility among People Living with Dementia in Residential Care Facilities: A Pilot Study
The Impact of Dual-Tasks and Disease Severity on Posture, Gait, and Functional Mobility among People Living with Dementia in Residential Care Facilities: A Pilot Study Open
Gait speed and timed-up-and-go (TUG) predict cognitive decline, falls, and mortality. Dual-tasks may be useful in cognitive screening among people living with dementia (PWD), but more evidence is needed. This cross-sectional study aimed to…
View article: Oral Microbially-Induced Small Extracellular Vesicles Cross the Blood–Brain Barrier
Oral Microbially-Induced Small Extracellular Vesicles Cross the Blood–Brain Barrier Open
Porphyromonas gingivalis (Pg) and its gingipain proteases contribute to Alzheimer’s disease (AD) pathogenesis through yet unclear mechanisms. Cellular secretion of small extracellular vesicles or exosomes (EXO) increases with aging as part…
View article: The Role of Aryl Hydrocarbon Receptor in Bone Biology
The Role of Aryl Hydrocarbon Receptor in Bone Biology Open
Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is crucial in maintaining the skeletal system. Our study focuses on encapsulating the role of AhR in bone biology and identifying novel signaling pathways in musculo…
View article: IMPACT OF DUAL-TASKING AND DEMENTIA DISEASE SEVERITY ON POSTURE, GAIT, AND FUNCTIONAL MOBILITY IN RESIDENTIAL CARE
IMPACT OF DUAL-TASKING AND DEMENTIA DISEASE SEVERITY ON POSTURE, GAIT, AND FUNCTIONAL MOBILITY IN RESIDENTIAL CARE Open
Dual-tasking may be a useful tool for fall-risk screening among people living with dementia (PWD), but more evidence is needed. Our aims were to compare single- and dual-task posture, gait and functional mobility; and examine the relations…
View article: ROLE OF THE METHYLTRANSFERASE METTL21C IN DRIVING MUSCLE ATROPHY WITH AGING AND HIV INFECTION
ROLE OF THE METHYLTRANSFERASE METTL21C IN DRIVING MUSCLE ATROPHY WITH AGING AND HIV INFECTION Open
Osteoporosis and sarcopenia are both frequently observed in older people living with HIV. We developed an animal model to investigate the cellular and molecular mechanisms underlying accelerated muscle aging in the setting of HIV infection…
View article: Editorial: Bone and muscle interactions in bone pathologies
Editorial: Bone and muscle interactions in bone pathologies Open
EDITORIAL article Front. Endocrinol., 07 November 2023Sec. Bone Research Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1326694
View article: The kynurenine pathway in HIV, frailty and inflammaging
The kynurenine pathway in HIV, frailty and inflammaging Open
Kynurenine (Kyn) is a circulating tryptophan (Trp) catabolite generated by enzymes including IDO1 that are induced by inflammatory cytokines such as interferon-gamma. Kyn levels in circulation increase with age and Kyn is implicated in sev…
View article: Engineered Human Dendritic Cell Exosomes as Effective Delivery System for Immune Modulation
Engineered Human Dendritic Cell Exosomes as Effective Delivery System for Immune Modulation Open
Exosomes (exos) contain molecular cargo of therapeutic and diagnostic value for cancers and other inflammatory diseases, but their therapeutic potential for periodontitis (PD) remains unclear. Dendritic cells (DCs) are the directors of imm…
View article: Uncovering the Gene Regulatory Network of Endothelial Cells in Mouse Duchenne Muscular Dystrophy: Insights from Single-Nuclei RNA Sequencing Analysis
Uncovering the Gene Regulatory Network of Endothelial Cells in Mouse Duchenne Muscular Dystrophy: Insights from Single-Nuclei RNA Sequencing Analysis Open
Introduction: Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder caused by mutations in the dystrophin gene, which leads to heart and respiratory failure. Despite the critical impact of DMD on endothelial cells (ECs)…
View article: Lyophilized Extracellular Vesicles from Adipose-Derived Stem Cells Increase Muscle Reperfusion but Degrade Muscle Structural Proteins in A Mouse Model of Hindlimb Ischemia-Reperfusion Injury
Lyophilized Extracellular Vesicles from Adipose-Derived Stem Cells Increase Muscle Reperfusion but Degrade Muscle Structural Proteins in A Mouse Model of Hindlimb Ischemia-Reperfusion Injury Open
Ischemia-reperfusion (I/R) injury is a complication impacting multiple organs and tissues in clinical conditions ranging from peripheral arterial disease to musculoskeletal trauma and myocardial infarction. Stem cell-derived extracellular …
View article: Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice Open
Emerging evidence shows that the microRNA-141-3p is involved in various age-related pathologies. Previously, our group and others reported elevated levels of miR-141-3p in several tissues and organs with age. Here, we inhibited the express…
View article: Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice
Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice Open
As the aging population grows, chronic age-related bone degenerative diseases become more prevalent and severe. One such disease, periodontitis (PD), rises to 70.1% prevalence in Americans 65 years and older. PD has been linked to increase…
View article: Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging
Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging Open
Extracellular vesicles (EVs), including exosomes and microvesicles, are released by numerous cell types. EVs are now acknowledged as playing a critical role in cell–cell communication in healthy aging as well as in age‐related diseases. Re…
View article: Proteomic analysis
Proteomic analysis Open
Proteomic analysis of lyophilized extracellular vesicles and skeletal muscles.